2-CHLORO-5-FLUORO-3-NITROPYRIDINE
- Product Name
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
- CAS No.
- 136888-21-6
- Chemical Name
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
- Synonyms
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE;2-CHLORO-3-NITRO-5-FLUOROPYRIDINE;Pyridine, 2-chloro-5-fluoro-3-nitro-;2-CHLORO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB1769379
- Molecular Formula
- C5H2ClFN2O2
- Formula Weight
- 176.53
- MOL File
- 136888-21-6.mol
2-CHLORO-5-FLUORO-3-NITROPYRIDINE Property
- Melting point:
- 48.0 to 52.0 °C
- Boiling point:
- 246℃
- Density
- 1.595
- Flash point:
- 103℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -4.94±0.10(Predicted)
- color
- White to Yellow to Green
- InChI
- InChI=1S/C5H2ClFN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H
- InChIKey
- SVVZGNAZMPSGMU-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(F)C=C1[N+]([O-])=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C3115
- Product name
- 2-Chloro-5-fluoro-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $267
- Updated
- 2025/07/31
- Product number
- C3115
- Product name
- 2-Chloro-5-fluoro-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $78
- Updated
- 2025/07/31
- Product number
- C585753
- Product name
- 2-Chloro-5-fluoro-3-nitropyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C585753
- Product name
- 2-Chloro-5-fluoro-3-nitropyridine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC50086
- Product name
- 2-Chloro-5-fluoro-3-nitropyridine
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
2-CHLORO-5-FLUORO-3-NITROPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
light powder
Synthesis
136888-20-5
136888-21-6
General procedure for the synthesis of 2-chloro-5-fluoro-3-nitropyridine from 2-hydroxy-3-nitro-5-fluoro-pyridine: 2-hydroxy-3-nitro-5-fluoro-pyridine (1.00 g, 5.33 mmol) was dissolved in acetonitrile (40 mL), followed by the addition of a solution of tetraethylammonium chloride (2.10 g, 12.65 mmol) in acetonitrile. After the mixture was clarified, phosphorus trichloride (1.94 g, 12.65 mmol) was added slowly and dropwise at room temperature. The reaction mixture was heated to 90°C and maintained for 24 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a yellow solid product (0.90 g, 69% yield), which was pure enough to be used directly in subsequent synthesis steps. Low resolution mass spectrometry (LRMS) showed m/z: 177 ([M+H]+).
References
[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 52
[2] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 43
[3] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 45
[4] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 2, p. 287 - 293
[5] Patent: US2004/110785, 2004, A1. Location in patent: Page 77
2-CHLORO-5-FLUORO-3-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-5-FLUORO-3-NITROPYRIDINE Suppliers
- Tel
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- Country
- France
- ProdList
- 303
- Advantage
- 58
View Lastest Price from 2-CHLORO-5-FLUORO-3-NITROPYRIDINE manufacturers
- Product
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE 136888-21-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2-CHLORO-5-FLUORO-3-NITROPYRIDINE 136888-21-6
- Price
- US $1.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-28