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2-CHLORO-5-FLUORO-3-NITROPYRIDINE

Product Name
2-CHLORO-5-FLUORO-3-NITROPYRIDINE
CAS No.
136888-21-6
Chemical Name
2-CHLORO-5-FLUORO-3-NITROPYRIDINE
Synonyms
2-CHLORO-5-FLUORO-3-NITROPYRIDINE;2-CHLORO-3-NITRO-5-FLUOROPYRIDINE;Pyridine, 2-chloro-5-fluoro-3-nitro-;2-CHLORO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber
CB1769379
Molecular Formula
C5H2ClFN2O2
Formula Weight
176.53
MOL File
136888-21-6.mol
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2-CHLORO-5-FLUORO-3-NITROPYRIDINE Property

Melting point:
48.0 to 52.0 °C
Boiling point:
246℃
Density 
1.595
Flash point:
103℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-4.94±0.10(Predicted)
color 
White to Yellow to Green
InChI
InChI=1S/C5H2ClFN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H
InChIKey
SVVZGNAZMPSGMU-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(F)C=C1[N+]([O-])=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3115
Product name
2-Chloro-5-fluoro-3-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$267
Updated
2025/07/31
TCI Chemical
Product number
C3115
Product name
2-Chloro-5-fluoro-3-nitropyridine
Purity
>98.0%(GC)
Packaging
200mg
Price
$78
Updated
2025/07/31
TRC
Product number
C585753
Product name
2-Chloro-5-fluoro-3-nitropyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C585753
Product name
2-Chloro-5-fluoro-3-nitropyridine
Packaging
500mg
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
PC50086
Product name
2-Chloro-5-fluoro-3-nitropyridine
Packaging
5g
Price
$88
Updated
2021/12/16
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2-CHLORO-5-FLUORO-3-NITROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

light powder

Synthesis

136888-20-5

136888-21-6

General procedure for the synthesis of 2-chloro-5-fluoro-3-nitropyridine from 2-hydroxy-3-nitro-5-fluoro-pyridine: 2-hydroxy-3-nitro-5-fluoro-pyridine (1.00 g, 5.33 mmol) was dissolved in acetonitrile (40 mL), followed by the addition of a solution of tetraethylammonium chloride (2.10 g, 12.65 mmol) in acetonitrile. After the mixture was clarified, phosphorus trichloride (1.94 g, 12.65 mmol) was added slowly and dropwise at room temperature. The reaction mixture was heated to 90°C and maintained for 24 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a yellow solid product (0.90 g, 69% yield), which was pure enough to be used directly in subsequent synthesis steps. Low resolution mass spectrometry (LRMS) showed m/z: 177 ([M+H]+).

References

[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 52
[2] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 43
[3] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 45
[4] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 2, p. 287 - 293
[5] Patent: US2004/110785, 2004, A1. Location in patent: Page 77

2-CHLORO-5-FLUORO-3-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUORO-3-NITROPYRIDINE Suppliers

Americas 1 China 123 Europe 1 France 1 Germany 1 India 4 Japan 1 United Kingdom 3 United States 18 Global 153
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 2-CHLORO-5-FLUORO-3-NITROPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-CHLORO-5-FLUORO-3-NITROPYRIDINE 136888-21-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Career Henan Chemical Co
Product
2-CHLORO-5-FLUORO-3-NITROPYRIDINE 136888-21-6
Price
US $1.00-2.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
100kg
Release date
2019-08-28

136888-21-6, 2-CHLORO-5-FLUORO-3-NITROPYRIDINERelated Search:

2-Chloro-5-fluoro-3-methylpyridine 2-Chloro-4-iodopyridine 2-Chloro-4-nitropyridine 1-oxide 2-Chloro-5-iodopyridine 2-Chloro-4-methyl-5-nitropyridine 2-Chloro-4-fluoropyridine 3-Amino-6-chloro-2-picoline 3-AMINO-6-CHLORO-4-PICOLINE 2-CHLORO-5-FLUORO-6-PICOLINE 2-Chloro-5-fluoro-4-methyl-pyridine Forchlorfenuron 2-CHLORO-3-FLUORO-4-NITROPYRIDINE N-OXIDE 5-CHLORO-2-FLUORO-3-NITROPYRIDINE 3-Amino-5-fluoropyridine 3-AMINO-2-CHLORO-5-FLUOROPYRIDINE 2-CHLORO-5-FLUORO-3-NITROPYRIDINE 2-CHLORO-5-FLUORO-3-NITRO-4-PICOLINE 2-CHLORO-3-FLUORO-4-NITROPYRIDINE

  • 2-CHLORO-3-NITRO-5-FLUOROPYRIDINE
  • 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
  • Pyridine, 2-chloro-5-fluoro-3-nitro-
  • 2-CHLORO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH
  • 136888-21-6
  • Fluorine series
  • Boronic Acid
  • Pyridine
  • Pyridines