2-Chloro-4-methyl-5-nitropyridine

Product Name: 2-Chloro-4-methyl-5-nitropyridine
CAS No.: 23056-33-9
Chemical Name: 2-Chloro-4-methyl-5-nitropyridine
Synonyms: 3-chloro-4-methyl-5-nitropyridine;-5-nitropyridine;2-chloro-4-methyl-;5-Nitro-2-chloro-4-picoline;2-CHLORO-5-NITRO-4-PICOLINE;2-Chloro-4-Methyl-5-nitro...;2-CHLORO-5-NITRO-4-PICOLINE 98+%;2-CHLORO-5-NITRO-4-METHYLPYRIDINE;2-CHLORO-4-METHYL-5-NITROPYRIDINE;2-CHIORO-4-METHYL-5-NITROPYRIDINE
CBNumber: CB7433106
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 23056-33-9.mol

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2-Chloro-4-methyl-5-nitropyridine Property

Melting point:: 37-39 °C (lit.)
Boiling point:: 91 °C/5 mmHg (lit.)
Density: 1.5610 (rough estimate)
refractive index: 1.5870 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Crystalline Powder or Chunks
pka: -3.42±0.10(Predicted)
color: Light cream to light brown
InChI: InChI=1S/C6H5ClN2O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3
InChIKey: HWZUMEVIIGNXGM-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C([N+]([O-])=O)C(C)=C1
CAS DataBase Reference: 23056-33-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36/37/39-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290122
Product name: 2-Chloro-4-methyl-5-nitropyridine
Purity: 97%
Packaging: 1g
Price: $74.4
Updated: 2023/01/07

TCI Chemical

Product number: C2021
Product name: 2-Chloro-4-methyl-5-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: C2021
Product name: 2-Chloro-4-methyl-5-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $94
Updated: 2025/07/31

TRC

Product number: C602228
Product name: 2-Chloro-4-methyl-5-nitropyridine
Packaging: 5g
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11856
Product name: 2-Chloro-4-methyl-5-nitropyridine
Purity: 96%
Packaging: 1g
Price: $3
Updated: 2021/12/16

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2-Chloro-4-methyl-5-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

light cream to light brown crystalline powder

Uses

2-Chloro-4-methyl-5-nitropyridine may be used in chemical synthesis studies.

Synthesis

21901-41-7

23056-33-9

General procedure for the synthesis of 2-chloro-5-nitro-4-methylpyridine from 2-hydroxy-4-methyl-5-nitropyridine: 1. 2-Hydroxy-4-methyl-5-nitropyridine (500 mg, 3.24 mmol), POCl3 (0.5 mL) and PCl5 (200 mg) were mixed and stirred at 150°C for 2 hrs. 2. After completion of the reaction, cooled to room temperature, the reaction mixture was poured into ice and extracted with dichloromethane (DCM, 3 x 20 mL). 3. The organic phases were combined, washed with water to pH 7, dried over Na2SO4 and concentrated under reduced pressure. 4. The obtained residue was dried under reduced pressure to give the crude product 2-chloro-4-methyl-5-nitropyridine (480 mg, 86% yield). In the presence of PdCl2(PPh3)2 (42 mg, 0.06 mmol), P(t-Bu)3 (16 mg, 0.08 mmol) and TEA (1.5 mL), 2-chloro-4-methyl-5-nitropyridine (172 mg, 1.00 mmol) was mixed with 3-ethynyl-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one (199 mg, 1.00 mmol) in DMF (3 mL) at 100°C for 3 hours. The crude product was purified by column chromatography (silica gel) to afford the intermediate 7,7-dimethyl-3-((4-methyl-5-nitropyridin-2-yl)ethynyl)-7,8-dihydroquinolin-5(6H)-one (115 mg, 34% yield). A solution of 7,7-dimethyl-3-((4-methyl-5-nitropyridin-2-yl)ethynyl)-7,8-dihydroquinolin-5(6H)-one (114 mg, 0.34 mmol) and SnCl2-2H2O (380 mg, 1.70 mmol) in EtOH (10 mL) was stirred at reflux for 6 hours. After completion of the reaction, it was cooled to room temperature, poured into ice, adjusted to pH 7-8 with saturated aqueous NaHCO3 solution and extracted with EtOAc (3 × 30 mL). The organic phases were combined, dried over Na2SO4 and concentrated under reduced pressure. The resulting residue was purified by washing with hexane and acetonitrile to afford the target product 2-chloro-5-nitro-4-methylpyridine (60 mg, 58% yield). 1H NMR (DMSO-d6) δ: 1.07 (s, 6H), 2.08 (s, 3H), 2.60 (s, 2H), 3.02 (s, 2H), 5.51 (s, 2H), 7.23 (s, 1H), 7.90 (s, 1H), 8.17 (s, 1H), 8.80 (s, 1H). LC/MS (M+H)+ = 306.

References

[1] Patent: WO2012/52451, 2012, A1. Location in patent: Page/Page column 117-118
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[3] Journal of the Chemical Society, 1954, p. 1190,1192
[4] Journal of the Chemical Society, 1954, p. 2448,2455
[5] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 12

2-Chloro-4-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

5-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBALDEHYDE 5-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID 5-ACETYLAMINO-2-CHLORO-4-PICOLINE

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2-Chloro-4-methyl-5-nitropyridine Suppliers

Americas 1 Belgium 2 China 285 Europe 4 France 1 Germany 4 India 39 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 12 United States 52 Global 404

Ningbo Fuhe Chemical Co., Ltd.

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Liaoning Tianhua Chemical Co., Ltd.

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INTATRADE GmbH

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 2-Chloro-4-methyl-5-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-4-methyl-5-nitropyridine 23056-33-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-4-methyl-5-nitropyridine 23056-33-9
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Honest Joy Holdings Limited

Product: 2-Chloro-4-methyl-5-nitropyridine 23056-33-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.5%
Supply Ability: 100 tons
Release date: 2022-01-26

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2-Chloro-4-methyl-5-nitropyridine ,98%

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2-Chloro-4-Methyl-5- nitropyridine, 2-Chloro-5-nitro-4-picoline

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-5-nitropyridine

2-Chloro-4-methyl-5-nitropyridine ISO 9001：2015 REACH

23056-33-9

3056-33-9

23059-33-9

21056-33-9

23056-33-0

C6H5C1N2O2

Building Blocks

Halopyridines

Chloropyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Heterocycle-Pyridine series

nitro-compound| alkyl chloride

Chlorinated heterocyclic series

pyridine series

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Boronic Acid

Chloropyridines

Halopyridines

Pyridines

Pyridine Derivertives

Pyridine

compounds of pyridine