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FUMONISIN B1

Product Name
FUMONISIN B1
CAS No.
116355-83-0
Chemical Name
FUMONISIN B1
Synonyms
FB1;MACROFUSINE;FUMONISIN B1;B1 Fumonisin B1;Fumonisin B1,96%;FUMONISIN B1 98%;Fumonisin B1 ,95%;Fumonisin B1 (FB1);fumonisin b1solution;FuMonisin B1, 96% 1MG
CBNumber
CB1773259
Molecular Formula
C34H59NO15
Formula Weight
721.83
MOL File
116355-83-0.mol
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FUMONISIN B1 Property

Melting point:
>60oC
Boiling point:
713.81°C (rough estimate)
Density 
1.2207 (rough estimate)
refractive index 
1.6630 (estimate)
Flash point:
6 °C
storage temp. 
2-8°C
solubility 
Soluble in Water (up to 25 mg/ml).
form 
Powder
pka
3?+-.0.23(Predicted)
color 
White to tan
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference
116355-83-0
IARC
2B (Vol. 56) 1993, 2B (Vol. 82) 2002
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
40-36-20/21/22-11
Safety Statements 
36/37-16-26-45
RIDADR 
3172
WGK Germany 
3
RTECS 
TZ8350000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29221990
Hazardous Substances Data
116355-83-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
344850-M
Product name
Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem
Purity
A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC?? = 100 nM).
Packaging
1mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
34139
Product name
Fumonisin B1 solution
Purity
50?μg/mL in acetonitrile: water, analytical standard
Packaging
1ML
Price
$291
Updated
2024/03/01
Sigma-Aldrich
Product number
32936
Product name
Fumonisin B1
Purity
reference material
Packaging
5mg
Price
$1260
Updated
2024/03/01
Cayman Chemical
Product number
62580
Product name
Fumonisin B1
Purity
≥95%
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
62580
Product name
Fumonisin B1
Purity
≥95%
Packaging
5mg
Price
$324
Updated
2024/03/01
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FUMONISIN B1 Chemical Properties,Usage,Production

Description

Fumonisin B1 (116355-83-0) inhibits ceramide synthesis (sphinganine N-acyltransferase), IC50 = 100 nM. Inhibits de novo sphingolipid biosynthesis (IC50 = 0.7 μM) thereby blocking glycosphingolipid production.

Chemical Properties

white to tan powder

Uses

A mycotoxin produced by mold associated with corn. Fungal metabolite believed to cause leukoencephalomalacia in horses.

Uses

A serine/threonine phosphatase inhibitor.

Uses

Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons.

Definition

ChEBI: Fumonisin B1 is a diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. It has a role as a metabolite and a carcinogenic agent. It is a fumonisin, a primary amino compound, a diester and a triol. It is functionally related to a (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. It is a conjugate acid of a fumonisin B1(3-).

General Description

Fumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.

Biological Activity

Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively.

Biochem/physiol Actions

Fumonisin B1 acts as a hepatocarcinogen and causes hepatotoxicity in rats. In horses, it causes leukoencephalitis, and in pigs, it causes pulmonary edema syndrome. In China and southern parts of Africa, it is linked with high incidence of esophageal cancer in humans. It acts as an inhibitor of sphingosine N-acyltransferase enzyme (ceramide synthase), related to structural similarities between fumonisin B1 and sphingoid bases like sphingosine.

storage

Store at +4°C

References

1) Merrill et al. (1993), Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ; J. Biol. Chem., 268 27299

FUMONISIN B1 Preparation Products And Raw materials

Raw materials

Preparation Products

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FUMONISIN B1 Suppliers

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