Lenzilumab

Product Name: Lenzilumab
CAS No.: 1229575-09-0
Chemical Name: Lenzilumab
Synonyms: Lenzilumab;Lenzilumab (anti-GM-CSF);Research Grade Lenzilumab;Research Grade Lenzilumab(DHC06703)
CBNumber: CB18080915
Formula Weight: 0
MOL File: Mol file

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Lenzilumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Lenzilumab Chemical Properties,Usage,Production

Uses

Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies[1][2].

in vivo

Lenzilumab (i.p., 10 mg/kg, daily, 10 days) inhibits GM-CSF without inhibiting the cellular function of CAR-T and enhances its antitumor activity in NSG mice^[1].

Animal Model:	NSG mice with CART19 cells^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; daily; 10 days
Result:	Neutralized GM-CSF, had antitumor activity and improved the proliferation of cytokine release syndrome (CRS) and neuroinflammation (NI).

References

[1] Rosalie M Sterner, et al. GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts. Blood. 2019 Feb 14;133(7):697-709. DOI:10.1182/blood-2018-10-881722
[2] Zelalem Temesgen, et al. GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia: A Case-Cohort Study. Mayo Clin Proc. 2020 Nov;95(11):2382-2394. DOI:10.1016/j.mayocp.2020.08.038

Lenzilumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Lenzilumab Suppliers

China 14 United States 1 Global 15

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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Guangzhou Hongyuan Chemical Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Changsha Fuzhen Biotechnology Co.，LTD

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Wanxin Biotechnology (Jiaxing) Co., LTD

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1229575-09-0, LenzilumabRelated Search:

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Lenzilumab

Research Grade Lenzilumab(DHC06703)

Research Grade Lenzilumab

Lenzilumab (anti-GM-CSF)

1229575-09-0