Pomalidomide-NH-PEG3-azide

Product Name: Pomalidomide-NH-PEG3-azide
CAS No.: 2271036-46-3
Chemical Name: Pomalidomide-NH-PEG3-azide
Synonyms: IUN-36463;Pomalidomide-NH-PEG3-azide;Pomalidomide 4'-PEG3-azide;4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber: CB18363902
Molecular Formula: C21H26N6O7
Formula Weight: 474.47
MOL File: 2271036-46-3.mol

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Pomalidomide-NH-PEG3-azide Property

form: Solid
color: Light yellow to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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Pomalidomide-NH-PEG3-azide Chemical Properties,Usage,Production

Uses

Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

storage

Store at -20°C

References

[1] Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2

Pomalidomide-NH-PEG3-azide Preparation Products And Raw materials

Raw materials

Preparation Products

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Pomalidomide-NH-PEG3-azide Suppliers

China 27 Global 27

SHANGHAI FDC-CHEMICAL CO.,LTD

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Xi'an Confluore Biological Technology Co., Ltd.

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View Lastest Price from Pomalidomide-NH-PEG3-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-NH-PEG3-azide 2271036-46-3
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2271036-46-3, Pomalidomide-NH-PEG3-azideRelated Search:

Pomalidomide-NH-PEG2-azide Pomalidomide-NH-PEG6-azide Pomalidomide-PEG4-azide Pomalidomide-NH-PEG1-azide Pomalidomide-NH-PEG5-azide 1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1) 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Poma-NH-C4-N3 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) POMALIDOMIDE-PEG2-CO2H Pomalidomide-PEG4-CO2H Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1) 4-((5-azidopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG3-CO2H 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-

Pomalidomide-NH-PEG3-azide

IUN-36463

4-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Pomalidomide 4'-PEG3-azide

1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

2271036-46-3