4-BROMO-8-HYDROXYQUINOLINE
- Product Name
- 4-BROMO-8-HYDROXYQUINOLINE
- CAS No.
- 139399-63-6
- Chemical Name
- 4-BROMO-8-HYDROXYQUINOLINE
- Synonyms
- 4-BroMoquinolin-8-ol;NSC 673456;4-BroMo-8-quinolinol;8-Quinolinol, 4-broMo-;4-BROMO-8-HYDROXYQUINOLINE
- CBNumber
- CB1842580
- Molecular Formula
- C9H6BrNO
- Formula Weight
- 224.05
- MOL File
- 139399-63-6.mol
4-BROMO-8-HYDROXYQUINOLINE Property
- Density
- 1.705
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Appearance
- white solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B998960
- Product name
- 4-Bromoquinolin-8-Ol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H01-9-X0
- Product name
- 4-Bromo-8-hydroxyquinoline
- Packaging
- 250mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- W3050
- Product name
- 4-Bromo-8-hydroxyquinoline
- Packaging
- 250mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- 4H01-9-X0
- Product name
- 4-Bromo-8-hydroxyquinoline
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- HCH0352215
- Product name
- 4-BROMO-8-HYDROXYQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.79
- Updated
- 2021/12/16
4-BROMO-8-HYDROXYQUINOLINE Chemical Properties,Usage,Production
Synthesis
103028-31-5
139399-63-6
General procedure for the synthesis of 4-bromo-8-hydroxyquinoline using 4-bromo-8-methoxyquinoline as starting material: 1.5 g (0.006 mol) of 4-bromo-8-methoxyquinoline (CAS No. 103028-31-5) was dissolved in 10 ml of 48% aqueous hydrobromic acid (CAS No. 10035-10-6). The reaction mixture was stirred under reflux conditions for 24 hours. Upon completion of the reaction, 50 ml of water was added for dilution, followed by neutralization of the reaction solution with 2 M aqueous sodium hydroxide solution. The neutralized solution was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by rapid chromatography on a silica gel column with the mobile phase being a solvent mixture of dichloromethane and methanol (initial ratio dichloromethane:methanol = 90:5, gradient elution with the proportion of methanol increased from 5% to 15%). Finally, 0.84 g of the target product 4-bromo-8-hydroxyquinoline was obtained in 59% yield. The product was analyzed by LC-MS (Method 2): retention time (Rt) = 0.94 min; mass-to-charge ratio (m/z) = 225.09 ([M+H]+).1H-NMR (300 MHz, DMSO-d6) data were as follows: δ [ppm] = 7.16-7.19 (m, 1H), 7.51-7.61 (m, 2H), 7.93 (d, 1H), 7.93 (d, 1H), 8.64 (d, 1H). 1H), 8.64 (d, 1H), 10.09 (s, 1H).
References
[1] Monatshefte fuer Chemie, 1991, vol. 122, # 11, p. 935 - 942
[2] Patent: US2017/233345, 2017, A1. Location in patent: Paragraph 0759-0762
[3] Journal of the Chemical Society, 1957, p. 290,293
[4] Journal of Fluorescence, 2018, vol. 28, # 5, p. 1121 - 1126
4-BROMO-8-HYDROXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-8-HYDROXYQUINOLINE manufacturers
- Product
- 4-Bromo-8-hydroxyquinoline 139399-63-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26