ChemicalBook > CAS DataBase List > 4-BROMO-8-HYDROXYQUINOLINE

4-BROMO-8-HYDROXYQUINOLINE

Product Name: 4-BROMO-8-HYDROXYQUINOLINE
CAS No.: 139399-63-6
Chemical Name: 4-BROMO-8-HYDROXYQUINOLINE
Synonyms: 4-BroMoquinolin-8-ol;NSC 673456;4-BroMo-8-quinolinol;8-Quinolinol, 4-broMo-;4-BROMO-8-HYDROXYQUINOLINE
CBNumber: CB1842580
Molecular Formula: C9H6BrNO
Formula Weight: 224.05
MOL File: 139399-63-6.mol

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4-BROMO-8-HYDROXYQUINOLINE Property

Density: 1.705
storage temp.: Inert atmosphere,Store in freezer, under -20°C
Appearance: white solid

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B998960
Product name: 4-Bromoquinolin-8-Ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-9-X0
Product name: 4-Bromo-8-hydroxyquinoline
Packaging: 250mg
Price: $61
Updated: 2021/12/16

AK Scientific

Product number: W3050
Product name: 4-Bromo-8-hydroxyquinoline
Packaging: 250mg
Price: $91
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-9-X0
Product name: 4-Bromo-8-hydroxyquinoline
Packaging: 1g
Price: $157
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0352215
Product name: 4-BROMO-8-HYDROXYQUINOLINE
Purity: 95.00%
Packaging: 5MG
Price: $500.79
Updated: 2021/12/16

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4-BROMO-8-HYDROXYQUINOLINE Chemical Properties,Usage,Production

Synthesis

103028-31-5

139399-63-6

General procedure for the synthesis of 4-bromo-8-hydroxyquinoline using 4-bromo-8-methoxyquinoline as starting material: 1.5 g (0.006 mol) of 4-bromo-8-methoxyquinoline (CAS No. 103028-31-5) was dissolved in 10 ml of 48% aqueous hydrobromic acid (CAS No. 10035-10-6). The reaction mixture was stirred under reflux conditions for 24 hours. Upon completion of the reaction, 50 ml of water was added for dilution, followed by neutralization of the reaction solution with 2 M aqueous sodium hydroxide solution. The neutralized solution was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by rapid chromatography on a silica gel column with the mobile phase being a solvent mixture of dichloromethane and methanol (initial ratio dichloromethane:methanol = 90:5, gradient elution with the proportion of methanol increased from 5% to 15%). Finally, 0.84 g of the target product 4-bromo-8-hydroxyquinoline was obtained in 59% yield. The product was analyzed by LC-MS (Method 2): retention time (Rt) = 0.94 min; mass-to-charge ratio (m/z) = 225.09 ([M+H]+).1H-NMR (300 MHz, DMSO-d6) data were as follows: δ [ppm] = 7.16-7.19 (m, 1H), 7.51-7.61 (m, 2H), 7.93 (d, 1H), 7.93 (d, 1H), 8.64 (d, 1H). 1H), 8.64 (d, 1H), 10.09 (s, 1H).

References

[1] Monatshefte fuer Chemie, 1991, vol. 122, # 11, p. 935 - 942
[2] Patent: US2017/233345, 2017, A1. Location in patent: Paragraph 0759-0762
[3] Journal of the Chemical Society, 1957, p. 290,293
[4] Journal of Fluorescence, 2018, vol. 28, # 5, p. 1121 - 1126

4-BROMO-8-HYDROXYQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-BROMO-8-HYDROXYQUINOLINE manufacturers

Honest Joy Holdings Limited

Product: 4-Bromo-8-hydroxyquinoline 139399-63-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.2%
Supply Ability: 100 tons
Release date: 2022-01-26

139399-63-6, 4-BROMO-8-HYDROXYQUINOLINERelated Search:

4-BROMO-7-NITROQUINOLINE 4-bromo-1H-pyrazolo[3,4-b]pyridine 4-BROMO-8-METHYLQUINOLINE 4-BROMO-8-FLUOROQUINOLINE 4-BROMO-8-TRIFLUOROMETHYLQUINOLINE 4-BROMO-8-CHLOROQUINOLINE Iodoform Azelaic acid Fluoranthene OXINE-COPPER 4-BROMO-8-METHOXYQUINOLINE 4-BROMO-8-METHOXY-2-METHYLQUINOLINE 4-BROMO-7,8-DIMETHOXYQUINOLINE 4-BROMO-8-HYDROXYQUINOLINE

4-BROMO-8-HYDROXYQUINOLINE

4-BroMo-8-quinolinol

NSC 673456

4-BroMoquinolin-8-ol

8-Quinolinol, 4-broMo-

139399-63-6