Anti-cancer properties
ChemicalBook > CAS DataBase List > 3-Mercaptopropionic acid

3-Mercaptopropionic acid

Anti-cancer properties
Product Name
3-Mercaptopropionic acid
CAS No.
107-96-0
Chemical Name
3-Mercaptopropionic acid
Synonyms
3-Mercaptopropanoic acid;3-MPA;3-mercaptopropionic;3-thiopropionicacid;3-Thiopropionic acid;Thiopropionic acid;3-mercapto-propionicaci;3-mercapto-propanoicaci;3-Sulfanylpropanoic acid;3-Mercaptopropionic acid ( MPA)
CBNumber
CB1852730
Molecular Formula
C3H6O2S
Formula Weight
106.14
MOL File
107-96-0.mol
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3-Mercaptopropionic acid Property

Melting point:
15-18 °C (lit.)
Boiling point:
110-111 °C/15 mmHg (lit.)
Density 
1.218 g/mL at 25 °C (lit.)
vapor pressure 
0.04 mm Hg ( 20 °C)
refractive index 
n20/D 1.492(lit.)
FEMA 
4587 | 3-MERCAPTOPROPIONIC ACID
Flash point:
201 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
pK1:;pK2:10.84(SH) (25°C)
form 
Crystalline Powder, Crystals, and/or Chunks
color 
White
Specific Gravity
1.218
PH
2 (120g/l, H2O, 20℃)
Odor
sulfurous roasted
Odor Type
sulfurous
explosive limit
1.60%(V)
Water Solubility 
soluble
Sensitive 
Air Sensitive & Hygroscopic
JECFA Number
1936
BRN 
773807
Stability:
Air Sensitive, Hygroscopic
InChIKey
DKIDEFUBRARXTE-UHFFFAOYSA-N
LogP
-2.3 at 22℃
CAS DataBase Reference
107-96-0(CAS DataBase Reference)
NIST Chemistry Reference
3-Thiolpropanoic acid(107-96-0)
EPA Substance Registry System
3-Mercaptopropanoic acid (107-96-0)
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Safety

Hazard Codes 
T
Risk Statements 
25-34-23/24/25
Safety Statements 
7-26-36/37/39-45
RIDADR 
UN 2922 8/PG 2
WGK Germany 
1
RTECS 
UF5270000
F 
10-13
Autoignition Temperature
662 °F
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29309070
Hazardous Substances Data
107-96-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 96 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

Precautionary statements

P234Keep only in original container.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M5801
Product name
3-Mercaptopropionic acid
Purity
≥99%
Packaging
5g
Price
$50.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05967
Product name
3-Mercaptopropionic acid
Purity
for synthesis
Packaging
100mL
Price
$46.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.05967
Product name
3-Mercaptopropionic acid
Purity
for synthesis
Packaging
250ML
Price
$91.4
Updated
2024/03/01
Sigma-Aldrich
Product number
63768
Product name
3-Mercaptopropionic acid
Purity
≥99.0% (HPLC)
Packaging
25ml
Price
$205
Updated
2024/03/01
TCI Chemical
Product number
M0061
Product name
3-Mercaptopropionic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$20
Updated
2024/03/01
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3-Mercaptopropionic acid Chemical Properties,Usage,Production

Anti-cancer properties

3-Mercaptopropionic acid is a liquid, and doses between 30 and 60 mg/kg can be used for IP seizure induction throughout development. 3-mercaptopropionic acid (3-MPA) is a convulsant and potent GAD1 inhibitor, which could inhibit the migration and invasiveness of oral cancer cells. Considering that inhibition of GAD1 impaired GABA-mediated immunosuppression, 3-MPA was also demonstrated to synergize with ICB treatment to exert better anti-tumor efficacy. Such a combination strategy could benefit the treatment of cancer types with elevated GAD1 expression. Since 3-MPA has not been approved for clinical use, it is urgent to discover novel GAD1 inhibitors that are more applicable to future clinical studies.

Chemical Properties

clear colourless to yellowish liquid after melting

Uses

A compound suitable for amino acid analysis by means of OPA

Uses

3-Mercaptopropionic acid is widely used in food and beverage industries as a flavoring agent. It is used in the production of PVC stabilizers, which are used as chain transfer agents in polymerizations. It can be used as primary or secondary, color stabilizer in combination with phenolic antioxidant for polymers. It acts as a sulfide ion equivalent and is utilized in the preparation of diaryl sulfide from aryl iodide.

Definition

ChEBI: A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.

Application

3-Mercaptopropionic acid (3-MPA)  is used to produce hydrophilic SAMs, which are terminated with carboxylic acids and can be further functionalized to introduce more complex end groups such as enzymes for biosensor applications. SAMs of 3-MPA are capped on ZnSe quantum dots for the electrochemical detection of dopamine. 3-MPA is used as a capping agent on CdTe quantum dot nanocrystals (QD NCs) for use as labeling materials in biomedical applications. It can also be used to modify the surface of iron oxide nanoparticles (Fe2O3) in the extraction and preconcentration of Al3+ and Cr3+ ions from different biological samples.

General Description

3-Mercaptopropionic acid (3-MPA) is used as a self-assembled monolayer (SAM) with a thiol and carboxylic groups. It has short carbon chains and is mainly used as a capping agent on a variety of nanoparticles.

Biological Activity

3-Mercaptopropionic acid is a blocking drug that causes an increase in sleep and a decrease in wakefulness. A related finding is that nipecotic acid also increases the time needed for isoflurane to induce loss of consciousness, whereas 3-mercaptopropionic acid decreases anesthesia induction time[1].

References

[1] Thakkar, M. and R. McCarley. “Neurochemistry of Sleep and Wakefulness: Histamine in the control of sleep–wakefulness.”Basic Neurochemistry (Eighth Edition) (2012).

3-Mercaptopropionic acid Preparation Products And Raw materials

Raw materials

Hydrogen Sulfide 2-Oxetanone Pyruvic acid Acrylonitrile Thiourea

Preparation Products

graft copolymer PAA-G-PIPA microsphere Butyl 3-mercaptopropionate 2-(4-CHLOROPHENYL)-3-METHYL-TETRAHYDRO-1,3-THIAZINE-4-ONE 3-METHYLTHIOPROPIONIC ACID Chlormezanone
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View Lastest Price from 3-Mercaptopropionic acid manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
3-Mercaptopropionic acid 107-96-0
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3-Mercaptopropionic acid 107-96-0
Price
US $40.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-08
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Mercapto Propionic Acid 107-96-0
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-31

107-96-0, 3-Mercaptopropionic acidRelated Search:

POTASSIUM THIOGLYCOLATE Sodium thioglycolate 3-Mercapto-2-pentanone Ethyl 2-(Chlorosulfonyl)acetate Folic acid Hyaluronic acid 2-Ethylhexyl mercaptoacetate Mercaptoacetic acid Calcium thioglycolate 6-Mercaptopurine Stearic acid Citric acid 4-chloro-2-cyclopropylpyrimidine Phenylmethylsulfonyl fluoride Ascoric Acid (R)-2-AMINO-3-MERCAPTOPROPIONIC ACID,l-2-amino-3-mercaptopropionic acid 3-MERCAPTOPROPIONIC ACID METHYL ESTER 2-Mercaptoethanol

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