5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

Product Name: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione
CAS No.: 150728-12-4
Chemical Name: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione
Synonyms: Bosenta dione;Bosentan Impurity 13;Bosentan interMediate;5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4;5-(2-Methoxyphenoxy)-[2,2'-BipyriMidine]-4,6(1H,5H)-;(RS)-5-(2-methoxy-phenoxy)-1H-[22]bipyrimidine-4,6-dione;5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione;5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1h,5h)-dione;5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione;2,2'-Bipyrimidine]-4,6(1H,5H)-dione, 5-(2-methoxyphenoxy)-
CBNumber: CB1855094
Molecular Formula: C15H12N4O4
Formula Weight: 312.28
MOL File: 150728-12-4.mol

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5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Property

Density: 1.45
storage temp.: 2-8°C
pka: 6.23±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C15H12N4O4/c1-22-9-5-2-3-6-10(9)23-11-14(20)18-13(19-15(11)21)12-16-7-4-8-17-12/h2-8,11H,1H3,(H,18,19,20,21)
InChIKey: ZJMPECSQUMNGPA-UHFFFAOYSA-N
SMILES: C1(C2=NC=CC=N2)NC(=O)C(OC2=CC=CC=C2OC)C(=O)N=1
CAS DataBase Reference: 150728-12-4(CAS DataBase Reference)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M226535
Product name: 5-(2-Methoxyphenoxy)-[2,2''-bipyrimidine]-4,6(1H,5H)-dione
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 7549AA
Product name: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione
Packaging: 25g
Price: $207
Updated: 2021/12/16

Matrix Scientific

Product number: 091105
Product name: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione
Purity: 95+%
Packaging: 250mg
Price: $439
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0012388
Product name: 5-(2-METHOXYPHENOXY)-[2,2'-BIPYRIMIDINE]-4,6(1H,5H)-DIONE
Purity: 95.00%
Packaging: 1G
Price: $808.5
Updated: 2021/12/16

Matrix Scientific

Product number: 091105
Product name: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione
Purity: 95+%
Packaging: 1g
Price: $975
Updated: 2021/12/16

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5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Chemical Properties,Usage,Production

Synthesis

20730-58-9

16879-48-4

150728-12-4

Step 3: Synthesis of 5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidine-4,6(1H,5H)-dione Sodium (0.69 g, 30 mmol) was dissolved in anhydrous ethanol (40 mL) under nitrogen protection, followed by the addition of diethyl 2-(2-methoxyphenoxy)malonate (2.82 g, 10 mmol) and 2-amidinopyrimidinium benzenesulfonate (2.8 g, 10 mmol) to an ethanol (30 mL) solution, in that order. The reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the mixture was poured into ice water, acidified with 3M hydrochloric acid to pH ≈ 2, and then concentrated until a precipitate precipitated. The precipitate was collected by filtration, washed with water and dried to give 804 mg of yellow solid product in 25% yield. Product characterization data. 1H NMR (300 MHz, DMSO-d6) δ 3.84 (s, 3H), 6.68 (d, J = 6.9 Hz, 1H), 6.77 (t, J = 7.5 Hz, 1H), 6.91 (t, J = 7.5 Hz, 1H), 7.05 (d, J = 6.9 Hz, 1H), 9.05 (d, J = 5.1 Hz, 2H), 12.19 (br, 2H). 12.19 (br, 2H). ESI-MS, m/z = 313 (M + H+). Note: 5-(2-methoxyphenoxy)-[2,2'-dipyrimidinyl]-4,6(1H,5H)-dione can be prepared with reference to the method described in Example 1 step 3.

References

[1] Patent: US2008/242687, 2008, A1. Location in patent: Page/Page column 32; 34

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione Suppliers

China 119 Germany 1 India 6 United States 8 Global 134

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View Lastest Price from 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione 150728-12-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-(2-methoxyphenoxy)-[2,2"-Bipyrimidine]-4,6(1H,5H)-dione 150728-12-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-(2-methoxyphenoxy)-[2,2"-Bipyrimidine]-4,6(1H,5H)-dione 150728-12-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

150728-12-4, 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dioneRelated Search:

p-Anisidine p-Anisaldehyde 4-Methoxyphenol Guaiacol 4-Methoxybenzyl alcohol (Trifluoromethoxy)benzene 4-Methoxybenzyl cyanide Anisole 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester 2-Cyanopyrimidine Bosentan Bosentan Impurity 1 Diethyl chloromalonate Bosentan Impurity 17 Bosentan Impurity 5 Bosentan Impurity 7 Bosentan Impurity 2 Bosentan Impurity

5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1h,5h)-dione

5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidine-4,6(1H,5H)-dione

5-(2-METHOXYPHENOXY)-2-(PYRIMIDIN-2-YL)PYRIMIDINE-4,6(1H,5H)-DIONE,PURITY:98% MIN(HPLC)

5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

5-(O-methoxyphenoxy)-2-pymidin-2-yl)-4,6-(1H,5H)-pymidine dione

Bosentan interMediate

5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)-1,4,5,6-tetrahydropyriMidine-4,6-dione

5-(2-Methoxyphenoxy)-[2,2'-BipyriMidine]-4,6(1H,5H)-

Bosenta dione

(RS)-5-(2-methoxy-phenoxy)-1H-[22]bipyrimidine-4,6-dione

5-(2-Methoxyphenxoy)-[2,2'-bipyrimidine]-4

Bosentan Impurity 13

2,2'-Bipyrimidine]-4,6(1H,5H)-dione, 5-(2-methoxyphenoxy)-

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione CAS NO.150728-12-4 CAS NO.150728-12-4

5- (2-Methoxyphenoxy) - [2,2 '- pyrimidine] -4,6 (1H, 5H) - dione

5- (2-Methoxyphenoxy) - [2,2 '- Dipyrimidine] -4,6 (1H, 5H) - dione

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6[1H,5H]-dione

150728-12-4

Heterocycle-Pyrimidine series

pyrimidine