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Orciprenaline

Product Name
Orciprenaline
CAS No.
586-06-1
Chemical Name
Orciprenaline
Synonyms
orciprenaline;Orciprenaline USP/EP/BP;Epinephrine Impurity 43;Orciprenaline & Orciprenaline Sulfate;Isoprenaline Hydrochloride Impurity 28;Metaproterenol (base and/or unspecified salts);1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;5-[1-hydroxy-2-(isopropylamino)ethyl]resorcinol;5-[2-(Isopropylamino)-1-hydroxyethyl]-1,3-benzenediol;3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol
CBNumber
CB1855195
Molecular Formula
C11H17NO3
Formula Weight
211.26
MOL File
586-06-1.mol
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Orciprenaline Property

Melting point:
100°
Boiling point:
350.94°C (rough estimate)
Density 
1.1240 (rough estimate)
refractive index 
1.5718 (estimate)
pka
9.11±0.10(Predicted)
CAS DataBase Reference
586-06-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0006235
Product name
METAPROTERENOL
Purity
95.00%
Packaging
1G
Price
$253.05
Updated
2021/12/16
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Orciprenaline Chemical Properties,Usage,Production

Originator

Alupent, Boehringer Ingelheim ,W. Germany ,1961

Uses

Bronchodilator.

Definition

ChEBI: Metaproterenol is a member of phenylethanolamines.

Manufacturing Process

In an initial operation, 3,5-diacetoxyacetophenone was reacted first with bromine and then with isopropylamine to give 1-(3,5-dihydroxyphenyl)-2- isopropylaminoethanone.
59 g of 1-(3,5-dihydroxy-phenyl)-2-isopropylaminoethanone (free base) were dissolved in 590 cc of methanol, and the solution was hydrogenated in the presence of about 80 g Raney nickel at room temperature and under a pressure of 5 atm. Hydrogen absorption was terminated after a few minutes. The catalyst was separated by vacuum filtration, and the filtrate, an ethanolic solution of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane, was admixed with the calculated amount of an alcoholic 20% sulfuric acid solution. A crystalline precipitate formed which was filtered off and washed with alcohol. For purification, the product was dissolved in water and the solution was filtered through iron-free charcoal.
Thereafter, the filtrate was evaporated to dryness in vacuo and the residue was taken up in alcohol. The crystalline precipitate which separated out after some standing was separated by vacuum filtration and washed with alcohol. After recrystallization from 90% alcohol, 61 g (83.2% of theory) of 1-(3,5- dihydroxyphenyl)-1-hydroxy-2-isopropylamino-ethane sulfate, MP 202° to 203°C, was obtained.

Therapeutic Function

Bronchodilator

Clinical Use

Metaproterenol was the first β- sympathomimetic drug with metabolic stability to achieve wide clinical use.

Orciprenaline Preparation Products And Raw materials

Raw materials

Preparation Products

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Orciprenaline Suppliers

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View Lastest Price from Orciprenaline manufacturers

Hebei Duling International Trade Co. LTD
Product
Orciprenaline 586-06-1
Price
US $23.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-02-01
Dideu Industries Group Limited
Product
Orciprenaline 586-06-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-05-28
Shaanxi Dideu Medichem Co. Ltd
Product
Orciprenaline 586-06-1
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-04-24

586-06-1, OrciprenalineRelated Search:


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