2-(4-isobutylphenyl)propionaldehyde

Product Name: 2-(4-isobutylphenyl)propionaldehyde
CAS No.: 51407-46-6
Chemical Name: 2-(4-isobutylphenyl)propionaldehyde
Synonyms: Ibuprofen Aldehyde;Ibuprofen Impurity 75;2-(4-Isobutylphenyl)propanal;2-(4-isobutylphenyl)propionaldehyde;p-(2-Methylpropyl)hydratropaldehyde;2-[4-(2-Methylpropyl)phenyl]propanal;α-Methyl-4-isobutylbenzeneacetaldehyde;(2RS)-2-[4-(2-Methylpropyl)phenyl]propan-1-al;A-METHYL-4-(2-METHYLPROPYL)BENZENEACETALDEHYDE;α-Methyl-4-(2-methylpropyl)benzeneacetaldehyde
CBNumber: CB1902754
Molecular Formula: C13H18O
Formula Weight: 190.28
MOL File: 51407-46-6.mol

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2-(4-isobutylphenyl)propionaldehyde Property

Boiling point:: 64-65 °C(Press: 0.2 Torr)
Density: 0.937±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
color: Colourless
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: I780360
Product name: 2-(4-Isobutylphenyl)propanal
Packaging: 25mg
Price: $310
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0308024
Product name: 2-(4-ISOBUTYLPHENYL)PROPIONALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $502.52
Updated: 2021/12/16

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2-(4-isobutylphenyl)propionaldehyde Chemical Properties,Usage,Production

Uses

2-(4-Isobutylphenyl)propanal is an impurity of the drug Ibuprofen (I140000), a selective cyclooxygenase inhibitor that also inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.

Production Methods

Numerous methods are known for the synthesis of 2-(4-isobutylphenyl)propionaldehyde. It can be prepared by reaction of p-isobutylacetophenone with methyl chloroacetate using sodium methoxide as catalyst, followed by reaction of the glycidic ester with BF3 to give 2- hydroxy-3-(4-isobutylphenyl)-3-butenoic acid methyl ester, which is subsequently treated with mineral acid Avariant of the process is the hydrolysis of the intermediately formed glycidic ester with alkali to give the corresponding salt of glycidic acid, which is then decarboxylated. In addition, 2-(4-isobutylphenyl)propanal is formed by isomerization of 2-(4-isobutylphenyl)- 2-methyloxirane on Al2O3-SiO2 or anhydrous ZnCl2, by reaction of 1-(4-isobutylphenyl)- 1-chloroethane with dimethylformamide in the presence of Li or Na in tetrahydrofuran, and in good yields by Rh- or Co-catalyzed hydroformylation of p-isobutylstyrene.

2-(4-isobutylphenyl)propionaldehyde Preparation Products And Raw materials

Raw materials

Ethyl butyrate Aluminum chloride Sodium Butyrate Sodium propan-2-olate Ethyl chloroacetate

Preparation Products

2-(4-isobutylphenyl)propionaldehyde oxime

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51407-46-6, 2-(4-isobutylphenyl)propionaldehydeRelated Search:

1-Hydroxyibuprofen Ibuprofen Isopropyl Ester 1-Oxo Ibuprofen Ibuprofen Ethyl Ester 1,3-bis(4-isobutylphenyl)butan-1-one 2-(4-Methylphenyl)propanoic acid Ibuprofen Ester Impurity Ibuprofen Impurity 4 4'-(2-Methylpropyl)acetophenone 4-(2-Methylpropyl)benzeneethanol 4-Benzyloxybenzaldehyde Ibuprofen EP Impurity I 3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID Ibuprofen Impurity 2 CARBOXYIBUPROFEN p-Isobutylstyrene rac a-Hydroxy Ibuprofen Ibuprofen Impurity 10

A-METHYL-4-(2-METHYLPROPYL)BENZENEACETALDEHYDE

2-(4-Isobutylphenyl)propanal

2-[4-(2-Methylpropyl)phenyl]propanal

p-(2-Methylpropyl)hydratropaldehyde

α-Methyl-4-isobutylbenzeneacetaldehyde

alpha-Methyl-4-(2-Methylpropyl)benzeneacetaldehyde

2-(4-isobutylphenyl)propionaldehyde

α-Methyl-4-(2-methylpropyl)benzeneacetaldehyde

Ibuprofen Aldehyde

Benzeneacetaldehyde, α-methyl-4-(2-methylpropyl)-

Ibuprofen Impurity 75

(2RS)-2-[4-(2-Methylpropyl)phenyl]propan-1-al

51407-46-6