2-(4-isobutylphenyl)propionaldehyde
- Product Name
- 2-(4-isobutylphenyl)propionaldehyde
- CAS No.
- 51407-46-6
- Chemical Name
- 2-(4-isobutylphenyl)propionaldehyde
- Synonyms
- Ibuprofen Aldehyde;Ibuprofen Impurity 75;2-(4-Isobutylphenyl)propanal;2-(4-isobutylphenyl)propionaldehyde;p-(2-Methylpropyl)hydratropaldehyde;2-[4-(2-Methylpropyl)phenyl]propanal;α-Methyl-4-isobutylbenzeneacetaldehyde;(2RS)-2-[4-(2-Methylpropyl)phenyl]propan-1-al;A-METHYL-4-(2-METHYLPROPYL)BENZENEACETALDEHYDE;α-Methyl-4-(2-methylpropyl)benzeneacetaldehyde
- CBNumber
- CB1902754
- Molecular Formula
- C13H18O
- Formula Weight
- 190.28
- MOL File
- 51407-46-6.mol
2-(4-isobutylphenyl)propionaldehyde Property
- Boiling point:
- 64-65 °C(Press: 0.2 Torr)
- Density
- 0.937±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Colourless
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I780360
- Product name
- 2-(4-Isobutylphenyl)propanal
- Packaging
- 25mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- CHM0308024
- Product name
- 2-(4-ISOBUTYLPHENYL)PROPIONALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.52
- Updated
- 2021/12/16
2-(4-isobutylphenyl)propionaldehyde Chemical Properties,Usage,Production
Uses
2-(4-Isobutylphenyl)propanal is an impurity of the drug Ibuprofen (I140000), a selective cyclooxygenase inhibitor that also inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.
Production Methods
Numerous methods are known for the synthesis of 2-(4-isobutylphenyl)propionaldehyde. It can be prepared by reaction of p-isobutylacetophenone with methyl chloroacetate using sodium methoxide as catalyst, followed by reaction of the glycidic ester with BF3 to give 2- hydroxy-3-(4-isobutylphenyl)-3-butenoic acid methyl ester, which is subsequently treated with mineral acid Avariant of the process is the hydrolysis of the intermediately formed glycidic ester with alkali to give the corresponding salt of glycidic acid, which is then decarboxylated. In addition, 2-(4-isobutylphenyl)propanal is formed by isomerization of 2-(4-isobutylphenyl)- 2-methyloxirane on Al2O3-SiO2 or anhydrous ZnCl2, by reaction of 1-(4-isobutylphenyl)- 1-chloroethane with dimethylformamide in the presence of Li or Na in tetrahydrofuran, and in good yields by Rh- or Co-catalyzed hydroformylation of p-isobutylstyrene.