ChemicalBook > CAS DataBase List > Dexamethasone EP Impurity E

Dexamethasone EP Impurity E

Product Name: Dexamethasone EP Impurity E
CAS No.: 13209-41-1
Chemical Name: Dexamethasone EP Impurity E
Synonyms: VBP15;Dexamethasone EP Imp E;Dexamethasone impurity E;Dexamethasone Impurity L;Carbamazepine Impurity 22;Vamorolone, 10 mM in DMSO;(8S,10S,13S,14S,16R,17R)-17-hydroxy;16α-Methyl-9,11-dehydro Prednisolone;Tobramycin and dexamethasone impurity C;16Alpha-Methyl-9,11-dehydro Prednisolone
CBNumber: CB1921384
Molecular Formula: C22H28O4
Formula Weight: 356.46
MOL File: 13209-41-1.mol

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Dexamethasone EP Impurity E Property

Melting point:: 228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3))
Boiling point:: 548.3±50.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 12.53±0.70(Predicted)
color: Pale Yellow
InChIKey: ZYTXTXAMMDTYDQ-JBFVNPOPNA-N
SMILES: C1(=O)C=C2[C@](C)(C=C1)C1[C@]([H])([C@@]3([H])[C@@](CC=1)(C)[C@@](O)(C(=O)CO)[C@H](C)C3)CC2 |&1:4,9,11,13,17,23,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M295300
Product name: 16α-Methyl-9,11-dehydroPrednisolone
Packaging: 2mg
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-0030515
Product name: Vamorolone
Purity: 99.12%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0030515
Product name: Vamorolone
Purity: 99.12%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0030515
Product name: Vamorolone
Purity: 99.12%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0006582
Product name: 16-ALPHA-METHYL-9,11-DEHYDRO PREDNISOLONE
Purity: 95.00%
Packaging: 5MG
Price: $1094.5
Updated: 2021/12/16

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Dexamethasone EP Impurity E Chemical Properties,Usage,Production

Uses

A related intermediate of Prednisolone (P703740).

Biological Activity

Vamorolone, a synthetic steroid, is an orally available dissociative steroid with anti-inflammatory efficacy. It is a partial agonist of the glucocorticoid receptor (NR3C1) th at appear to be safe and well tolerated. Also, vamorolone is a potent antagonist of the mineralocorticoid receptor (NR3C2). It is under development for children with Duchenne muscular dystrophy.

in vivo

Vamorolone (5-30 mg/kg; cherry syrup) shows a superior side effect profile compared to pharmacological glucocorticoids in mdx mice^[1].
? Vamorolone (30 mg/kg; orally; daily for 20 days) reduces CNS Inflammation in murine experimental autoimmune encephalomyelitis^[2].

Animal Model:	C57BL/6 mice (experimental autoimmune encephalomyelitis)^[2]
Dosage:	30 mg/kg
Administration:	Orally; daily for 20 days (starting one day prior to MOG 33-55 peptide immunization and continuing)
Result:	Reduced CNS inflammation in murine experimental autoimmune encephalomyelitis.

Toxics Screening Level

The ITSL for 17, 21-dihydroxy-16 alpha-methylpregna-1,4,9 (11)-triene-3, 20-dione has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on annual averaging time.

Dexamethasone EP Impurity E Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dexamethasone EP Impurity E manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Dexamethasone EP Impurity E 13209-41-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-13

13209-41-1, Dexamethasone EP Impurity ERelated Search:

PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone 21-Propionate Dexamethasone EP Impurity K HRPWQACPJGPYRH-XHFUFBBFSA-N 2-Methyltetrahydropyran Betamethasone 1,2-Dihydro Dexamethasone 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate Dexamethasone 21-phosphate disodium salt Dexamethasone palmitate 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) 16α-Methyl-11-oxo Prednisolone (11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione Desoximetasone Dexamethasone DexaMethasone IMpurity I 16-beta Methyl Epoxide DexaMethasone IMpurity K

17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione

16α-Methyl-9,11-dehydro Prednisolone

Dexamethasone impurity E

Dexamethasone Impurity 5(Dexamethasone EP Impurity E)

(16α)-17,21-Dihydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione

17.alpha.,21-Dihydroxy-16.alpha.-methylpregna-1,4,9(11)-triene-3,20-dione

Dexamethasone Impurity L

(8S,10S,13S,14S,16R,17R)-17-hydroxy

Dexamethasone EP Imp E

(8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one

((2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,11-dihydroxy-3,10a,12a-trimethyl-1,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-2-yl)methyl dihydrogen phosphate

17, 21-dihydroxy-16α-methylpregna- 1, 4, 9(11)-triene-3,20-dione

ethyl (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate

VBP15

inhibit,repair,Mineralocorticoid Receptor,VBP 15,Glucocorticoid Receptor,NF-κB,inflammation,Duchenne,Inhibitor,membrane,dystrophy,Vamorolone,Nuclear factor-κB,Nuclear factor-kappaB,muscular,VBP-15,glucocorticoid

Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16-methyl-, (16α)-

Tobramycin and dexamethasone impurity C

Carbamazepine Impurity 22

Vamorolone, 10 mM in DMSO

(16alpha)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione

16a-Methyl-9,11-dehydro prednisolone - Bio-X ?

16Alpha-Methyl-9,11-dehydro Prednisolone

13209-41-1

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