ChemicalBook > CAS DataBase List > Dexamethasone EP Impurity E

Dexamethasone EP Impurity E

Product Name
Dexamethasone EP Impurity E
CAS No.
13209-41-1
Chemical Name
Dexamethasone EP Impurity E
Synonyms
VBP15;Dexamethasone EP Imp E;Dexamethasone impurity E;Dexamethasone Impurity L;Carbamazepine Impurity 22;Vamorolone, 10 mM in DMSO;(8S,10S,13S,14S,16R,17R)-17-hydroxy;16α-Methyl-9,11-dehydro Prednisolone;Tobramycin and dexamethasone impurity C;Dexamethasone Impurity 5(Dexamethasone EP Impurity E)
CBNumber
CB1921384
Molecular Formula
C22H28O4
Formula Weight
356.46
MOL File
13209-41-1.mol
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Dexamethasone EP Impurity E Property

Melting point:
228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3))
Boiling point:
548.3±50.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
12.53±0.70(Predicted)
color 
Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M295300
Product name
16α-Methyl-9,11-dehydroPrednisolone
Packaging
2mg
Price
$155
Updated
2021/12/16
ChemScene
Product number
CS-0030515
Product name
Vamorolone
Purity
99.12%
Packaging
50mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006582
Product name
16-ALPHA-METHYL-9,11-DEHYDRO PREDNISOLONE
Purity
95.00%
Packaging
5MG
Price
$1094.5
Updated
2021/12/16
ChemScene
Product number
CS-0030515
Product name
Vamorolone
Purity
99.12%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0030515
Product name
Vamorolone
Purity
99.12%
Packaging
10mg
Price
$150
Updated
2021/12/16
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Dexamethasone EP Impurity E Chemical Properties,Usage,Production

Uses

A related intermediate of Prednisolone (P703740).

Biological Activity

Vamorolone, a synthetic steroid, is an orally available dissociative steroid with anti-inflammatory efficacy. It is a partial agonist of the glucocorticoid receptor (NR3C1) th at appear to be safe and well tolerated. Also, vamorolone is a potent antagonist of the mineralocorticoid receptor (NR3C2). It is under development for children with Duchenne muscular dystrophy.

Toxics Screening Level

The ITSL for 17, 21-dihydroxy-16 alpha-methylpregna-1,4,9 (11)-triene-3, 20-dione has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on annual averaging time.

Dexamethasone EP Impurity E Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dexamethasone EP Impurity E manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Dexamethasone EP Impurity E 13209-41-1
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-13

13209-41-1, Dexamethasone EP Impurity ERelated Search:


  • 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione
  • 16α-Methyl-9,11-dehydro Prednisolone
  • Dexamethasone impurity E
  • Dexamethasone Impurity 5(Dexamethasone EP Impurity E)
  • (16α)-17,21-Dihydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione
  • 17.alpha.,21-Dihydroxy-16.alpha.-methylpregna-1,4,9(11)-triene-3,20-dione
  • Dexamethasone Impurity L
  • (8S,10S,13S,14S,16R,17R)-17-hydroxy
  • Dexamethasone EP Imp E
  • (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one
  • ((2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,11-dihydroxy-3,10a,12a-trimethyl-1,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-2-yl)methyl dihydrogen phosphate
  • 17, 21-dihydroxy-16α-methylpregna- 1, 4, 9(11)-triene-3,20-dione
  • ethyl (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
  • VBP15
  • inhibit,repair,Mineralocorticoid Receptor,VBP 15,Glucocorticoid Receptor,NF-κB,inflammation,Duchenne,Inhibitor,membrane,dystrophy,Vamorolone,Nuclear factor-κB,Nuclear factor-kappaB,muscular,VBP-15,glucocorticoid
  • Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16-methyl-, (16α)-
  • Tobramycin and dexamethasone impurity C
  • Carbamazepine Impurity 22
  • Vamorolone, 10 mM in DMSO
  • (16alpha)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
  • 13209-41-1
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids