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treosulfan

Product Name
treosulfan
CAS No.
299-75-2
Chemical Name
treosulfan
Synonyms
CB-2562;Cb 40067;NSC 39069;Leo 40067;treosulfan;TREOSULPHAN;THREOSULFAN;Treosulfan D4;Dihydroxymyleran;Dihydroxybusulfan
CBNumber
CB1926495
Molecular Formula
C6H14O8S2
Formula Weight
278.3
MOL File
299-75-2.mol
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treosulfan Property

Melting point:
76-78 °C
Boiling point:
359.3°C (rough estimate)
Density 
1.305 (estimate)
refractive index 
1.5630 (estimate)
storage temp. 
Store at -20°C
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
pka
12.36±0.20(Predicted)
color 
Off-White to Pale Beige
CAS DataBase Reference
299-75-2
IARC
1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System
Treosulfan (299-75-2)
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Safety

RIDADR 
2811
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
299-75-2(Hazardous Substances Data)
Toxicity
LDLo intravenous in dog: 222mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1252
Product name
Treosulfan
Purity
≥98% (HPLC)
Packaging
5mg
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1252
Product name
Treosulfan
Purity
≥98% (HPLC)
Packaging
25mg
Price
$462
Updated
2024/03/01
ChemScene
Product number
CS-3889
Product name
Treosulfan
Purity
≥98.0%
Packaging
50mg
Price
$550
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024907
Product name
TREOSULFAN
Purity
95.00%
Packaging
5MG
Price
$660
Updated
2021/12/16
ChemScene
Product number
CS-3889
Product name
Treosulfan
Purity
≥98.0%
Packaging
5mg
Price
$85
Updated
2021/12/16
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treosulfan Chemical Properties,Usage,Production

Uses

Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).

Definition

ChEBI: Treosulfan is a methanesulfonate ester.

General Description

Odorless white crystalline powder.

Air & Water Reactions

Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .

Fire Hazard

Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Clinical Use

Alkylating agent for ovarian cancer

Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.

Metabolism

Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.

treosulfan Preparation Products And Raw materials

Raw materials

Preparation Products

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treosulfan Suppliers

Chengdu Junepharma Technology Co., Ltd
Tel
19938173342 19181793067
Email
1486288711@qq.com
Country
China
ProdList
167
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
Advantage
55
Birdo (Shanghai) Medical Technology Co., Ltd.
Tel
021-58099077
Fax
-
Email
sales@birdochem.com
Country
China
ProdList
185
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from treosulfan manufacturers

Wuhan Boyuan Import & Export Co., LTD
Product
Treosulfan 299-75-2
Price
US $46.00-26.00/kg
Min. Order
1kg
Purity
99.50%
Supply Ability
20tons
Release date
2023-04-11
Career Henan Chemical Co
Product
treosulfan 299-75-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg ,5kg, 50kg
Release date
2020-01-14

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