treosulfan

Product Name: treosulfan
CAS No.: 299-75-2
Chemical Name: treosulfan
Synonyms: CB-2562;Cb 40067;NSC 39069;Leo 40067;treosulfan;TREOSULPHAN;THREOSULFAN;Treosulfan D4;Dihydroxymyleran;Dihydroxybusulfan
CBNumber: CB1926495
Molecular Formula: C6H14O8S2
Formula Weight: 278.3
MOL File: 299-75-2.mol

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treosulfan Property

Melting point:: 76-78 °C
Boiling point:: 359.3°C (rough estimate)
Density: 1.305 (estimate)
refractive index: 1.5630 (estimate)
storage temp.: Store at -20°C
solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
pka: 12.36±0.20(Predicted)
color: Off-White to Pale Beige
CAS DataBase Reference: 299-75-2
IARC: 1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System: Treosulfan (299-75-2)

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Safety

RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 299-75-2(Hazardous Substances Data)
Toxicity: LDLo intravenous in dog: 222mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1252
Product name: Treosulfan
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $70.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1252
Product name: Treosulfan
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

ChemScene

Product number: CS-3889
Product name: Treosulfan
Purity: ≥98.0%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024907
Product name: TREOSULFAN
Purity: 95.00%
Packaging: 5MG
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-3889
Product name: Treosulfan
Purity: ≥98.0%
Packaging: 5mg
Price: $85
Updated: 2021/12/16

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treosulfan Chemical Properties,Usage,Production

Uses

Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).

Definition

ChEBI: Treosulfan is a methanesulfonate ester.

General Description

Odorless white crystalline powder.

Air & Water Reactions

Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .

Fire Hazard

Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Clinical Use

Alkylating agent for ovarian cancer

Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.

Metabolism

Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.

treosulfan Preparation Products And Raw materials

Raw materials

Preparation Products

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treosulfan Suppliers

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View Lastest Price from treosulfan manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Treosulfan 299-75-2
Price: US $46.00-26.00/kg
Min. Order: 1kg
Purity: 99.50%
Supply Ability: 20tons
Release date: 2023-04-11

Career Henan Chemical Co

Product: treosulfan 299-75-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg ,5kg, 50kg
Release date: 2020-01-14

299-75-2, treosulfanRelated Search:

Cyclophosphamide monohydrate (+)-1 4-DI-O-TOSYL-D-THREITOL (+)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENE-D-THREITOL Busulfan (+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE treosulfan

TREOSULPHAN

1,2,3,4-butanetetrol 1,4-dimethanesulfonate

(2S,3S)-1-O,4-O-Di(methylsulfonyl)-L-threitol

CB-2562

L-Dihydroxy-Busulfan

Leo 40067

NSC 39069

THREOSULFAN

treosulfan

(2S,3S)-Threitol 1,4-bismethanesulfonate

1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, [S-(R*,R*)]-

Cb 40067

Dihydroxybusulfan

Dihydroxymyleran

L-Threitol 1,4-dimethanesulfonate

L-Threitol, 1,4-bis(methanesulfonate)

L-Threitol-1,4-bis(methanesulfonate)

1,2,3,4-Butanetetrol,1,4-diMethanesulfonate, (2S,3S)-

Treosulfan >=98% (HPLC)

Treosulfan (NSC-39069

Treosulfan D4

Treosulfan,inhibit,DNA Alkylator/Crosslinker,Inhibitor,NSC39069,NSC-39069

299-75-2

C6H14O6S

API