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treosulfan

Product Name
treosulfan
CAS No.
299-75-2
Chemical Name
treosulfan
Synonyms
CB-2562;Cb 40067;NSC 39069;Leo 40067;treosulfan;TREOSULPHAN;THREOSULFAN;Treosulfan D4;Dihydroxymyleran;Dihydroxybusulfan
CBNumber
CB1926495
Molecular Formula
C6H14O8S2
Formula Weight
278.3
MOL File
299-75-2.mol
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treosulfan Property

Melting point:
76-78 °C
Boiling point:
359.3°C (rough estimate)
Density 
1.305 (estimate)
refractive index 
1.5630 (estimate)
storage temp. 
Store at -20°C
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
pka
12.36±0.20(Predicted)
color 
Off-White to Pale Beige
CAS DataBase Reference
299-75-2
IARC
1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System
Treosulfan (299-75-2)
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Safety

RIDADR 
2811
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
299-75-2(Hazardous Substances Data)
Toxicity
LDLo intravenous in dog: 222mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1252
Product name
Treosulfan
Purity
≥98% (HPLC)
Packaging
5mg
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1252
Product name
Treosulfan
Purity
≥98% (HPLC)
Packaging
25mg
Price
$462
Updated
2024/03/01
ChemScene
Product number
CS-3889
Product name
Treosulfan
Purity
≥98.0%
Packaging
5mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-3889
Product name
Treosulfan
Purity
≥98.0%
Packaging
50mg
Price
$550
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024907
Product name
TREOSULFAN
Purity
95.00%
Packaging
5MG
Price
$660
Updated
2021/12/16
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treosulfan Chemical Properties,Usage,Production

Uses

Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).

Definition

ChEBI: Treosulfan is a methanesulfonate ester.

General Description

Odorless white crystalline powder.

Air & Water Reactions

Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .

Fire Hazard

Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Clinical Use

Alkylating agent for ovarian cancer

Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.

Metabolism

Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.

treosulfan Preparation Products And Raw materials

Raw materials

Preparation Products

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treosulfan Suppliers

China 45 Finland 1 Germany 1 India 2 South Korea 1 United States 7 Global 57
Chengdu Junepharma Technology Co., Ltd
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NCE Biomedical Co.,Ltd.
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View Lastest Price from treosulfan manufacturers

Wuhan Boyuan Import & Export Co., LTD
Product
Treosulfan 299-75-2
Price
US $46.00-26.00/kg
Min. Order
1kg
Purity
99.50%
Supply Ability
20tons
Release date
2023-04-11
Career Henan Chemical Co
Product
treosulfan 299-75-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg ,5kg, 50kg
Release date
2020-01-14

299-75-2, treosulfanRelated Search:

Cyclophosphamide monohydrate (+)-1 4-DI-O-TOSYL-D-THREITOL (+)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENE-D-THREITOL Busulfan (+)-2,3-O-ISOPROPYLIDENE-D-THREITOL 1,4-DIMETHANE SULFONATE treosulfan

  • TREOSULPHAN
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  • 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, [S-(R*,R*)]-
  • Cb 40067
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  • L-Threitol, 1,4-bis(methanesulfonate)
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  • Treosulfan >=98% (HPLC)
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  • Treosulfan,inhibit,DNA Alkylator/Crosslinker,Inhibitor,NSC39069,NSC-39069
  • (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate , Treosulfan
  • (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate
  • 299-75-2
  • C6H14O6S
  • API