treosulfan
- Product Name
- treosulfan
- CAS No.
- 299-75-2
- Chemical Name
- treosulfan
- Synonyms
- CB-2562;Cb 40067;NSC 39069;Leo 40067;treosulfan;TREOSULPHAN;THREOSULFAN;Treosulfan D4;Dihydroxymyleran;Dihydroxybusulfan
- CBNumber
- CB1926495
- Molecular Formula
- C6H14O8S2
- Formula Weight
- 278.3
- MOL File
- 299-75-2.mol
treosulfan Property
- Melting point:
- 76-78 °C
- Boiling point:
- 359.3°C (rough estimate)
- Density
- 1.305 (estimate)
- refractive index
- 1.5630 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 12.36±0.20(Predicted)
- color
- Off-White to Pale Beige
- CAS DataBase Reference
- 299-75-2
- IARC
- 1 (Vol. 26, Sup 7, 100A) 2012
- EPA Substance Registry System
- Treosulfan (299-75-2)
Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 299-75-2(Hazardous Substances Data)
- Toxicity
- LDLo intravenous in dog: 222mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H340May cause genetic defects
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1252
- Product name
- Treosulfan
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $70.8
- Updated
- 2024/03/01
- Product number
- SML1252
- Product name
- Treosulfan
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $462
- Updated
- 2024/03/01
- Product number
- CS-3889
- Product name
- Treosulfan
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- API0024907
- Product name
- TREOSULFAN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CS-3889
- Product name
- Treosulfan
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2021/12/16
treosulfan Chemical Properties,Usage,Production
Uses
Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).
Definition
ChEBI: Treosulfan is a methanesulfonate ester.
General Description
Odorless white crystalline powder.
Air & Water Reactions
Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .
Fire Hazard
Flash point data for treosulfan are not available; however, treosulfan is probably combustible.
Clinical Use
Alkylating agent for ovarian cancer
Safety Profile
Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.
Metabolism
Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.
treosulfan Preparation Products And Raw materials
Raw materials
Preparation Products
treosulfan Suppliers
View Lastest Price from treosulfan manufacturers
- Product
- Treosulfan 299-75-2
- Price
- US $46.00-26.00/kg
- Min. Order
- 1kg
- Purity
- 99.50%
- Supply Ability
- 20tons
- Release date
- 2023-04-11
- Product
- treosulfan 299-75-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg ,5kg, 50kg
- Release date
- 2020-01-14