dichlorisone
- Product Name
- dichlorisone
- CAS No.
- 7008-26-6
- Chemical Name
- dichlorisone
- Synonyms
- Disoderm;Diloderm;9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;(11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9,11-dichloro-17,21-dihydroxy-, (11β)-;(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- CBNumber
- CB1932243
- Molecular Formula
- C21H26Cl2O4
- Formula Weight
- 413.34
- MOL File
- 7008-26-6.mol
dichlorisone Property
- Melting point:
- 238-241 °C (decomp)(Solv: acetone (67-64-1))
- alpha
- D20 +134° (pyridine)
- Boiling point:
- 586.4±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- solubility
- Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated)
- form
- Solid
- pka
- 11.99±0.70(Predicted)
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- D431755
- Product name
- Dichlorisone
- Packaging
- 25mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- D431755
- Product name
- Dichlorisone
- Packaging
- 250mg
- Price
- $1390
- Updated
- 2021/12/16
dichlorisone Chemical Properties,Usage,Production
Originator
Diloderm ,Schering,US,1960
Uses
Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.
Manufacturing Process
A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).
Therapeutic Function
Antipruritic, Antihistaminic, Appetite stimulant