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DICHLORISONE ACETATE

Product Name
DICHLORISONE ACETATE
CAS No.
79-61-8
Chemical Name
DICHLORISONE ACETATE
Synonyms
Sch 5005;DICHLORISONE ACETATE;dichlorisone 21-acetate;21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione;1, 4-PREGNADIEN-9α, 11β-DICHLORO-17, 21-DIOL-3, 20-DIONE 21-ACETATE;9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate;1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE;inhibit,Inhibitor,Dichlorisone,Endogenous Metabolite,Dichlorisone Acetate;Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11b)-;Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11β)-
CBNumber
CB0339584
Molecular Formula
C23H28Cl2O5
Formula Weight
455.37
MOL File
79-61-8.mol
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DICHLORISONE ACETATE Property

Melting point:
246-253 °C (decomp)
Boiling point:
596.2±50.0 °C(Predicted)
alpha 
D25 +162° (dioxane)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble)
pka
11.94±0.70(Predicted)
form 
Solid
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7866
Product name
Dichlorisone acetate
Purity
99.77%
Packaging
10mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-7866
Product name
Dichlorisone acetate
Purity
99.77%
Packaging
50mg
Price
$108
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000402
Product name
DICHLORISONE ACETATE
Purity
95.00%
Packaging
500MG
Price
$597.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000402
Product name
DICHLORISONE ACETATE
Purity
95.00%
Packaging
1G
Price
$695.39
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000402
Product name
DICHLORISONE ACETATE
Purity
95.00%
Packaging
5G
Price
$1050.24
Updated
2021/12/16
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DICHLORISONE ACETATE Chemical Properties,Usage,Production

Originator

Diloderm ,Schering,US,1960

Uses

antipruretic

Definition

ChEBI: Dichlorisone is a corticosteroid hormone.

Manufacturing Process

A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

brand name

Diloderm (Schering).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

DICHLORISONE ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DICHLORISONE ACETATE Suppliers

MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
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Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
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Country
China
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Novachemistry
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44-20819178-90 02081917890
Fax
(0)2080432064
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Country
United Kingdom
ProdList
4381
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
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Country
China
ProdList
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
ProdList
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Absin Bioscience Inc.
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021-38015121 15000105423
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wulan@absin.cn
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China
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cjbscvictory
Tel
13348960310 13348960310
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3003867561@qq.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
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58

79-61-8, DICHLORISONE ACETATERelated Search:


  • 9ALPHA,11BETA-DICHLORO-17ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE
  • 1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE
  • dichlorisone 21-acetate
  • 9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • 21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione
  • Sch 5005
  • [2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • [2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
  • acetic acid [2-[(9R,17R)-9,11-dichloro-17-hydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester
  • DICHLORISONE ACETATE
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11β)-
  • Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11b)-
  • inhibit,Inhibitor,Dichlorisone,Endogenous Metabolite,Dichlorisone Acetate
  • 1, 4-PREGNADIEN-9α, 11β-DICHLORO-17, 21-DIOL-3, 20-DIONE 21-ACETATE
  • 79-61-8
  • C23H28Cl2O5
  • Inhibitors
  • DILODERM