ChemicalBook > CAS DataBase List > Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

Product Name
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
CAS No.
106939-34-8
Chemical Name
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
Synonyms
7h-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid;(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester;Ethyl (S)-9;Levofloxacin-13;LEVOFLOXACIN ESTER;Ofloxacin Ethyl Ester;3-dihydro-7H-pyrido[1;LEVOFLOXACINCYCLIZEDESTER;Levofloxacin cyclic ester;4-benzoxazine-6-carboxylate
CBNumber
CB1949760
Molecular Formula
C15H13F2NO4
Formula Weight
309.26
MOL File
106939-34-8.mol
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Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Property

Melting point:
258-260°C
Boiling point:
442.2±45.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Acetic Acid (Slightly), Chloroform (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
-3.62±0.60(Predicted)
color 
Off-White to Light Yellow
InChI
InChI=1S/C15H13F2NO4/c1-3-21-15(20)9-5-18-7(2)6-22-14-11(17)10(16)4-8(12(14)18)13(9)19/h4-5,7H,3,6H2,1-2H3/t7-/m0/s1
InChIKey
TZSXJUSNOOBBOP-ZETCQYMHSA-N
SMILES
O1C2=C(F)C(F)=CC3C(=O)C(C(OCC)=O)=CN(C2=3)[C@@H](C)C1
CAS DataBase Reference
106939-34-8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
D445748
Product name
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcidEthylEster
Packaging
2g
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21854
Product name
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
Packaging
2g
Price
$280
Updated
2021/12/16
Matrix Scientific
Product number
094167
Product name
(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
Purity
95+%
Packaging
1g
Price
$284
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21854
Product name
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
Packaging
500mg
Price
$125
Updated
2021/12/16
AK Scientific
Product number
J52084
Product name
Levofloxacincyclizedester
Packaging
1g
Price
$140
Updated
2021/12/16
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Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Off-White Pale Yellow Solid

Uses

Levofloxacin intermediate.

Synthesis

2749-11-3

141-78-6

94695-48-4

109-94-4

106939-34-8

Step 1: 2.6 g of sodium hydride (60% dispersed in mineral oil), 50 mL of anhydrous toluene and 8.8 g of ethyl acetate were added sequentially to a dry reaction flask. It was stirred under nitrogen protection until an off-white suspension was formed. Subsequently, 8.8 g of ethyl formate was added slowly and the reaction was stirred at room temperature until complete. Upon completion of the reaction, the mixture was filtered under reduced pressure, the filter cake was collected and washed with anhydrous ether, followed by vacuum drying to give a white solid formyl ethyl acetate sodium salt. Step 2: In another dry reaction flask, 50 mL of anhydrous toluene, 5.5 g of sodium salt of methylacetate and 1.5 g of ZIF-67 ZnCoZIF catalyst were added and mixed well with stirring at room temperature. 7.7 g of 2,3,4,5-tetrafluorobenzoyl chloride was added dropwise slowly, and after the reaction was complete, 3.2 g of S-(+)-2-aminopropanol was added slowly and the reaction was heated to reflux temperature. After the reaction was completed, it was cooled to room temperature, an aqueous layer was added, the aqueous phase was extracted with toluene three times, the organic layers were combined, and the toluene was removed by distillation under reduced pressure to obtain the preliminary product. Step 3: The preliminary product obtained in step 2 was slowly added dropwise to 30 mL of anhydrous DMF solution containing 5.8 g of potassium fluoride, stirred and heated to reflux temperature for azeotropic dehydration. After completion of the reaction, DMF was removed by evaporation under reduced pressure and the residue was washed with water to neutrality to give a brown-yellow viscous solid. After vacuum drying, the intermediate (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid ethyl ester was obtained.

References

[1] Patent: CN108440562, 2018, A. Location in patent: Paragraph 0008; 0010-0015; 0016-0018; 0029

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Suppliers

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View Lastest Price from Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate 106939-34-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-11-29
Hebei Yanxi Chemical Co., Ltd.
Product
LEVOFLOXACIN ACID ESTER 106939-34-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99.00%
Supply Ability
20tons
Release date
2023-09-13
Qiuxian Baitai New Material Co., LTD
Product
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate 106939-34-8
Price
US $100.00/KG
Min. Order
100g
Purity
99%
Supply Ability
500ton/Month
Release date
2021-10-20

106939-34-8, Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylateRelated Search:

Levofloxacin heMihydrate Tribenuron methyl Oxygen-fluorine acid Levofloxacin Methyl acetate 1-AdaMantanethylaMine Chromium picolinate Levofloxacin carboxylic acid 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Methyl salicylate Quinolinic acid Kresoxim-methyl METSULFURON METHYL 2,5-PYRIDINEDICARBOXYLIC ACID N-Ethylmethylamine Sulfasalazine Thiophanate-methyl Piperazine

  • Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido
  • Levofloxacin cyclization ester
  • 7h-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid
  • (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carbox
  • ethyl (S)-9,10-difluoro-3-methyl-7- oxo-2,3-dihydro-7H- [1,4]oxazino[2,3,4-ij]quinoline-6- carboxylate
  • 7h-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-, Ethyl Ester, (3s)-
  • Levofloxacin carboxylic acid, ethyl ester
  • LEVOFLOXACINCYCLIZEDESTER
  • (3S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacidethylester
  • ETHYL (S)-9,10-DIFLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLATE
  • Ofloxacin Ethyl Ester
  • ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4] oxazino[2,3,4-ij]quinoline-6- ethyl carboxylate
  • 10-difluoro-3-methyl-7-oxo-2
  • 3-dihydro-7H-pyrido[1
  • 4-benzoxazine-6-carboxylate
  • Ethyl (S)-9
  • 7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID, 9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-, ETHYL ESTER
  • (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester
  • 9,10-Difluoro-3-(S)-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
  • (S)-Ethyl 9,10-difluoro-3-Methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
  • (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxyla
  • Levofloxacin-13
  • Ethyl (S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
  • Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxy
  • LEVOFLOXACIN ACID ESTER USP/EP/BP
  • (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester
  • Ethyl (3S)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
  • LEVOFLOXACIN ESTER
  • Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate or [levofloxacin acid ester
  • Ethyl (3S)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido1,2,3-debenzob1,4oxazine-6-carboxylate
  • Ethyl 8,9-Difluoro-3(S)-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylate
  • ethyl (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
  • (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid E
  • Ethyl(S)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
  • Levofloxacin cyclic ester
  • 106939-34-8
  • C15H13F2NO4
  • Various Intermediates
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • LEVOFLOXACIN INTERMIDATE