2,3,4-Trifluoro-5-Nitro-Benzoic Acid
- Product Name
- 2,3,4-Trifluoro-5-Nitro-Benzoic Acid
- CAS No.
- 197520-71-1
- Chemical Name
- 2,3,4-Trifluoro-5-Nitro-Benzoic Acid
- Synonyms
- 2,3,4-Trifluoro-5-Nitro-Benzoic Acid;Benzoic acid, 2,3,4-trifluoro-5-nitro-;2,3,4-Trifluoro-5-Nitro-Benzoic Acid, 10 mM in DMSO
- CBNumber
- CB1949917
- Molecular Formula
- C7H2F3NO4
- Formula Weight
- 221.09
- MOL File
- 197520-71-1.mol
2,3,4-Trifluoro-5-Nitro-Benzoic Acid Property
- Melting point:
- 130-132°
- Boiling point:
- 349.7±42.0 °C(Predicted)
- Density
- 1.748
- storage temp.
- 2-8°C
- pka
- 2.30±0.12(Predicted)
- form
- powder
- color
- White to off white
- InChI
- InChI=1S/C7H2F3NO4/c8-4-2(7(12)13)1-3(11(14)15)5(9)6(4)10/h1H,(H,12,13)
- InChIKey
- BCMIOBTWFPSPJJ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC([N+]([O-])=O)=C(F)C(F)=C1F
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H333May be harmful if inhaled
H350May cause cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- T895745
- Product name
- 2,3,4-Trifluoro-5-nitrobenzoicAcid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 044768
- Product name
- 5-Nitro-2,3,4-trifluorobenzoicacid
- Purity
- 96%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- J99697
- Product name
- 2,3,4-Trifluoro-5-nitrobenzoicacid
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- PC8688
- Product name
- 5-Nitro-2,3,4-trifluorobenzoicacid
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 4654-3-1U
- Product name
- 2,3,4-Trifluoro-5-nitrobenzoic acid
- Packaging
- 5G
- Price
- $44
- Updated
- 2021/12/16
2,3,4-Trifluoro-5-Nitro-Benzoic Acid Chemical Properties,Usage,Production
Chemical Properties
light yellow powder
Synthesis
61079-72-9
197520-71-1
2,3,4-Trifluorobenzoic acid (5) (10 g, 56.8 mmol) was used as a raw material, which was dissolved in concentrated sulfuric acid (98%, 33.0 g) and stirred until completely dissolved. A mixture consisting of concentrated nitric acid (65%, 6.0 g) and concentrated sulfuric acid (98%, 6.3 g) was slowly added dropwise over a temperature range of 90 to 95 °C. The dropwise process lasted for 3.5 hours. The reaction process was monitored by thin layer chromatography (TLC, the unfolding agent was a hexane solution of 30% ethyl acetate). Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently ice water (50 g) was added to quench the reaction. The precipitate was separated by centrifugation and dried at 50 to 55 °C for 8 hours. The crude product was purified by column chromatography and the eluent was a hexane solution of 20% ethyl acetate. Finally, the solvent was removed by distillation under reduced pressure to give the white solid product 2,3,4-trifluoro-5-nitrobenzoic acid (6) (12.2 g) in 97.1% yield.
References
[1] Journal of Chemical Research, 2015, vol. 39, # 6, p. 326 - 327
[2] Patent: WO2007/76245, 2007, A2. Location in patent: Page/Page column 18
[3] Patent: US2003/232869, 2003, A1. Location in patent: Page 9; 16
[4] Patent: WO2013/142182, 2013, A2. Location in patent: Page/Page column 21
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 10, p. 1905 - 1917
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View Lastest Price from 2,3,4-Trifluoro-5-Nitro-Benzoic Acid manufacturers
- Product
- 2,3,4-Trifluoro-5-Nitro-Benzoic Acid 197520-71-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 2,3,4-Trifluoro-5-nitrobenzoicacid 197520-71-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-23
- Product
- 2,3,4-trifluoro-5-nitrobenzoic acid 197520-71-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.9%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14