Obatoclax mesilate

Product Name: Obatoclax mesilate
CAS No.: 803712-79-0
Chemical Name: Obatoclax mesilate
Synonyms: Obato;CS-393;Gx 15-070;Gx015-070;Gx 15-070ms;Unii-39200fj43j;GX15070 Mesylate;GX15 070 Mesylate;GX15-070 Mesylate;OBATOCLAX MESYLATE
CBNumber: CB21011539
Molecular Formula: C20H19N3O.CH4O3S
Formula Weight: 413.49
MOL File: 803712-79-0.mol

More

Less

Obatoclax mesilate Property

storage temp.: -20°C
solubility: Soluble in DMSO (up to 5 mg/ml).
form: solid
color: Purple
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $180
Updated: 2024/03/01

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 10mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 50mg
Price: $893
Updated: 2024/03/01

Tocris

Product number: 6539
Product name: Obatoclaxmesylate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $730
Updated: 2021/12/16

More

Less

Obatoclax mesilate Chemical Properties,Usage,Production

Description

Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.

Chemical Properties

Red powder

Uses

Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.

Uses

Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

storage

Store at -20°C

References

1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149 2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413 3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789 4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409

Obatoclax mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Obatoclax mesilate Suppliers

China 121 India 1 United Kingdom 1 United States 23 Global 146

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38630
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

Gemin X Pharmaceuticals

Tel: --
Fax: --
Email: compound_request@geminx.com
Country: United States
ProdList: 1
Advantage: 60

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

LC Laboratories

Tel: --
Fax: --
Email: custserv@lclabs.com
Country: United States
ProdList: 503
Advantage: 50

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

More

Less

View Lastest Price from Obatoclax mesilate manufacturers

Career Henan Chemical Co

Product: Obatoclax mesilate 803712-79-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

803712-79-0, Obatoclax mesilateRelated Search:

Imatinib Dimethyl sulfoxide Trifluoromethanesulfonic acid Imatinib mesylate Pazufloxacin mesilate Pyrrole Methanesulfonic acid Pefloxacin mesylate Levofloxacin Methylate 2-Methoxyethanol Methylene Blue 4,4'-Diphenylmethane diisocyanate Sildenafil ETHANE Dimethyl fumarate Methylene Chloride Obatoclax mesilate Methoxy

OBATOCLAX MESYLATE

2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate

Obatoclax mesilate

1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-, monomethanesulfonate

Gx 15-070

Gx 15-070ms

Gx015-070

Unii-39200fj43j

Obatoclax (GX15-070)

Obatoclax, Methanesulfonate Salt

Obatoclax Mesylate (GX15-070)

CS-393

GX-15070, Obatoclax Mesylate

2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfo

(Z)-2-(5-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1H-indole mesylate

Obatoclax mesylate, >=98%

2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonat

Obatoclax mesylate(GX 015070)

Obatoclax mesilate USP/EP/BP

Obato

GX15 070 Mesylate

GX15070 Mesylate

GX15-070 Mesylate

Obatoclax Mesylate, 10 mM in DMSO

803712-79-0

C20H19N3OCH4O3S

Inhibitors

Inhibitor

INDOLE