ChemicalBook > CAS DataBase List > Pipobroman

Pipobroman

Product Name
Pipobroman
CAS No.
54-91-1
Chemical Name
Pipobroman
Synonyms
Amedel;A-8103;Vercyte;NSC-25154;Pipobroman;1,4-Bis(3-bromopropionyl)piperazine;1,4-Bis(3-bromo-1-oxopropyl)piperadine;1,4-Bis(3-bromo-1-oxopropyl)piperazine;1,1'-(1,4-Piperazinediyl)bis[3-bromo]-1-propanone;1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
CBNumber
CB21016761
Molecular Formula
C10H16Br2N2O2
Formula Weight
356.05
MOL File
54-91-1.mol
More
Less

Pipobroman Property

Melting point:
106-107℃
Boiling point:
487℃
Density 
1.691
refractive index 
1.6220 (estimate)
Flash point:
248℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
-0.56±0.70(Predicted)
color 
Crystals from H2O
EPA Substance Registry System
Pipobroman (54-91-1)
More
Less

Safety

Hazardous Substances Data
54-91-1(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 220 mg/kg IYKEDH 4,467,73
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3602
Product name
Pipobroman
Purity
≥98% (HPLC)
Packaging
10MG
Price
$69
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3602
Product name
Pipobroman
Purity
≥98% (HPLC)
Packaging
50MG
Price
$279
Updated
2024/03/01
TRC
Product number
P490600
Product name
Pipobroman
Packaging
1g
Price
$320
Updated
2021/12/16
Matrix Scientific
Product number
099654
Product name
1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
Purity
95+%
Packaging
5g
Price
$975
Updated
2021/12/16
Matrix Scientific
Product number
099654
Product name
1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
Purity
95+%
Packaging
10g
Price
$1650
Updated
2021/12/16
More
Less

Pipobroman Chemical Properties,Usage,Production

Originator

Vercyte ,Abbott ,US ,1966

Uses

diuretic, antihypertensive

Definition

ChEBI: Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an antineoplastic agent and an alkylating agent. It is a N-acylpiperazine, a tertiary carboxamide and an organobromine compound.

Manufacturing Process

To a solution of 17.2 g (0.10 mol) of 3-bromopropionyl chloride in 100 ml of anhydrous benzene was added dropwise with stirring a solution of 8.6 g (0.10 mol) of anhydrous piperazine in 20 ml of dry chloroform over a period of 30 minutes. The temperature rose spontaneously to 45°C during the addition. After the temperature ceased to rise, stirring was continued for another hour. The reaction mixture was then filtered to remove the piperazine hydrochloride by-product. The filtrate was evaporated to dryness and the residue recrystallized from ethanol to obtain the desired N,N'-bis-(3bromopropionyl)piperazine as a white crystalline solid melting at 103°C to 104°C. The identity of the product was further established by elemental analysis.

brand name

Vercyte (Abbott).

Therapeutic Function

Antineoplastic

Safety Profile

Poison by ingestion,subcutaneous and intraperitoneal routes. An experimentalteratogen. Other experimental reproductive effects.Human mutation data reported. When heated todecomposition it emits very toxic fumes of Br- and NOx.

Pipobroman Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pipobroman Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0

54-91-1, PipobromanRelated Search:


  • 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
  • Pipobroman
  • 1,4-Bis(3-bromo-1-oxopropyl)piperadine
  • A-8103
  • Amedel
  • NSC-25154
  • Vercyte
  • 3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
  • 1,1'-(1,4-Piperazinediyl)bis[3-bromo]-1-propanone
  • 1,4-Bis(3-bromo-1-oxopropyl)piperazine
  • 1,4-Bis(3-bromopropionyl)piperazine
  • 1-Propanone, 1,1'-(1,4-piperazinediyl)bis[3-bromo-
  • Inhibitor,Pipobroman,MDS,DNA Alkylator/Crosslinker,AML,myeloproliferative neoplasm,thrombosis,Polycythemia vera,inhibit,cutaneous squamous cell carcinoma
  • 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
  • 54-91-1
  • C10H16Br2N2O2
  • HYDROMOX