(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 885280-38-6
Chemical Name: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: 3-(Boc-aMino)cyclohexanone;3-N-BOC-AMINO CYCLOHEXANONE;3-(Boc-amino)cyclohexanone,95%;TERT-BUTYL 3-OXOCYCLOHEXYLCARBAMATE;tert-butyl N-(3-oxocyclohexyl)carbaMate;3-Aminocyclohexan-1-one, N-BOC protected;(3-Oxo-cyclohexyl)-carbaMic acid benzyl ester;2-Methyl-2-propanyl (3-oxocyclohexyl)carbamate;(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, (3-oxocyclohexyl)-, 1,1-dimethylethyl ester
CBNumber: CB2102577
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 885280-38-6.mol

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(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: 81-85oC
Boiling point:: 335.9±31.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.01±0.20(Predicted)
form: Solid
color: Pale Beige
InChI: InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-8-5-4-6-9(13)7-8/h8H,4-7H2,1-3H3,(H,12,14)
InChIKey: VGDCXKATFLOEHF-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1CCCC(=O)C1
CAS DataBase Reference: 885280-38-6

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Safety

HS Code: 2922390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: O849850
Product name: (3-Oxocyclohexyl)carbamicAcidtert-ButylEster
Packaging: 1g
Price: $140
Updated: 2021/12/16

Usbiological

Product number: 265715
Product name: 3-N-Boc-aminocyclohexanone
Packaging: 500mg
Price: $347
Updated: 2021/12/16

AK Scientific

Product number: J51193
Product name: 3-N-Boc-Aminocyclohexanone
Packaging: 1g
Price: $35
Updated: 2021/12/16

Matrix Scientific

Product number: 074452
Product name: 3-N-Boc-Aminocyclohexanone
Purity: 95+%
Packaging: 1g
Price: $39
Updated: 2021/12/16

Apolloscientific

Product number: OR301088
Product name: 3-Aminocyclohexan-1-one,N-BOCprotected
Purity: 97%
Packaging: 1g
Price: $51
Updated: 2021/12/16

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(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

(3-Oxocyclohexyl)carbamic Acid tert-Butyl Ester is used to prepare (benzyloxy)benzamides as TRPM8 antagonists.

Synthesis

610302-03-9

885280-38-6

General procedure for the synthesis of N-Boc-3-cyclohexanone amine from tert-butyl 3-hydroxycyclohexylcarbamate: To a solution of tert-butyl (3-hydroxycyclohexyl)carbamate (4.40 g, 20.46 mmol) in dichloromethane (DCM, 250 mL) was added Dess-Martin periodinane (13.0 g, 30.70 mmol). The reaction mixture was cooled in an ice bath and then stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with DCM and washed with aqueous sodium carbonate. The organic layer was separated and dried with anhydrous sodium sulfate and subsequently concentrated. The crude product was purified by silica gel column chromatography (eluent: 40% petroleum ether solution of ethyl acetate) to afford N-Boc-3-cyclohexanone amine (4.0 g, 18.78 mmol, 91% yield). Mass spectrum (ESI) m/z 214.1 [M + H]+.

References

[1] Patent: US2015/175557, 2015, A1. Location in patent: Paragraph 0383
[2] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 736

(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

Canada 1 China 162 India 1 United Kingdom 2 United States 19 Global 185

Accela ChemBio Inc.

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View Lastest Price from (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Sach biotech Co.,Ltd

Product: 3-N-Boc-aminocyclohexanone 885280-38-6
Price: US $570.00-500.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5mt
Release date: 2025-06-08

Career Henan Chemical Co

Product: (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER 885280-38-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

885280-38-6, (3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

benzyl N-(3,3-difluorocyclohexyl)carbaMate 1-BOC-4-CBZ-AMINO-PIPERIDINE 1-Boc-5-hydroxyindole Tert-butyl pyrazolo[1,5-a]pyriMidin-3-ylcarbaMate T-butyl-3-oxocyclobutanecarboxylate N-Boc-4-(Cyclopropylmethyl)piperazine TERT-BUTYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) N-Boc-2-aminoacetaldehyde N-(BOC)-6-fluoro-indole N-BOC-7-BENZYL-2,7-DIAZASPIRO[3.5]NONANE N-Boc-N,N-bis(2-bromoethyl)amine tert-butyl N-[(2-chloropyridin-4-yl)Methyl]carbaMate TERT-BUTYL 4-IODOBUTYLCARBAMATE Carbamic acid, (3-cyanophenyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, 4-pentenyl-, 1,1-dimethylethyl ester (9CI) Hydrazinecarboxylic acid, 1-(2-propenyl)-, 1,1-diMethylethyl ester tert-butyl 5-aminopentanoate

TERT-BUTYL 3-OXOCYCLOHEXYLCARBAMATE

(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

3-N-BOC-AMINO CYCLOHEXANONE

tert-butyl N-(3-oxocyclohexyl)carbaMate

3-(Boc-aMino)cyclohexanone

Carbamic acid, (3-oxocyclohexyl)-, 1,1-dimethylethyl ester

(3-Oxo-cyclohexyl)-carbaMic acid benzyl ester

3-Aminocyclohexan-1-one, N-BOC protected

tert-Butyl (3-oxocyclohexyl)carbamate, 1-[(tert-Butoxycarbonyl)amino]-3-oxocyclohexane

Carbamic acid,N-(3-oxocyclohexyl)-, 1,1-dimethylethyl ester

3-(Boc-amino)cyclohexanone,95%

2-Methyl-2-propanyl (3-oxocyclohexyl)carbamate

885280-38-6