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Dibenzepin

Product Name
Dibenzepin
CAS No.
4498-32-2
Chemical Name
Dibenzepin
Synonyms
HF 1927;Dibenzepin;4498-32-12;5-(2-dimethylaminoethyl)-11-methylbenzo[b][1,4]benzodiazepin-6-one;5-(2-dimethylaminoethyl)-11-methyl-benzo[b][1,4]benzodiazepin-6-one;5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine;5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one;10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one;10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one;10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one
CBNumber
CB21105957
Molecular Formula
C18H21N3O
Formula Weight
295.38
MOL File
4498-32-2.mol
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Dibenzepin Property

Melting point:
116-117°C
Boiling point:
bp0.01 185°
Density 
1.1190 (rough estimate)
refractive index 
1.5855 (estimate)
storage temp. 
Refrigerator
solubility 
Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
pka
8.25(at 25℃)
form 
Solid
color 
Light Beige to Brown
CAS DataBase Reference
4498-32-2
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Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D416920
Product name
Dibenzepin
Packaging
50mg
Price
$1355
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21524
Product name
Dibenzepin
Packaging
2mg
Price
$139.9
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21524
Product name
Dibenzepin
Packaging
5mg
Price
$254.4
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21524
Product name
Dibenzepin
Packaging
10mg
Price
$462.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007971
Product name
DIBENZEPIN
Purity
95.00%
Packaging
5MG
Price
$774.4
Updated
2021/12/16
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Dibenzepin Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Noveril ,Wander,Switz.,1965

Uses

Antidepressant

Definition

ChEBI: 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone is a dibenzodiazepine.

Manufacturing Process

4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane. After adding a concentrated benzenic solution of β-dimethylamino-ethyl chloride freshly prepared from 3.75 grams of the hydrochloride with concentrated sodium hydroxide solution, taking up in benzene and drying the solution with potash, the mixture was boiled for 16 hours under reflux, whereupon the reaction mixture was concentrated to dryness and the residue distributed between ether and water. By exhaustive extraction of the basic fractions with dilute acetic acid, precipitation with ammonia, taking up the base in ether and working up the ethereal solution, there was obtained 5.05 grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11- dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous yellowish resin with the boiling point 185°C/0.01mm Hg. The base was crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of the monohydrochloride (from ethanol-ether) 234°-240°C.

Therapeutic Function

Psychostimulant

Dibenzepin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dibenzepin Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
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58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
17691182729 13992773979
Email
1049@dideu.com
Country
China
ProdList
8012
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49978
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
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58

4498-32-2, DibenzepinRelated Search:


  • 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one
  • 5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine
  • HF 1927
  • Dibenzepin
  • 10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one
  • 10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one
  • 5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one
  • 4498-32-12
  • 5-(2-dimethylaminoethyl)-11-methyl-benzo[b][1,4]benzodiazepin-6-one
  • 5-(2-dimethylaminoethyl)-11-methylbenzo[b][1,4]benzodiazepin-6-one
  • 11H-Dibenzo[b,e][1,4]diazepin-11-one, 10-[2-(dimethylamino)ethyl]-5,10-dihydro-5-methyl-
  • 4498-32-2
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  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals