Dibenzepin

Product Name: Dibenzepin
CAS No.: 4498-32-2
Chemical Name: Dibenzepin
Synonyms: HF 1927;Dibenzepin;4498-32-12;5-(2-dimethylaminoethyl)-11-methylbenzo[b][1,4]benzodiazepin-6-one;5-(2-dimethylaminoethyl)-11-methyl-benzo[b][1,4]benzodiazepin-6-one;5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine;5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one;10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one;10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one;10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one
CBNumber: CB21105957
Molecular Formula: C18H21N3O
Formula Weight: 295.38
MOL File: 4498-32-2.mol

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Dibenzepin Property

Melting point:: 116-117°C
Boiling point:: bp0.01 185°
Density: 1.1190 (rough estimate)
refractive index: 1.5855 (estimate)
storage temp.: Refrigerator
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
pka: 8.25(at 25℃)
form: Solid
color: Light Beige to Brown
CAS DataBase Reference: 4498-32-2

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D416920
Product name: Dibenzepin
Packaging: 50mg
Price: $1355
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21524
Product name: Dibenzepin
Packaging: 50mg
Price: $1529
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007971
Product name: DIBENZEPIN
Purity: 95.00%
Packaging: 50MG
Price: $1871.1
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21524
Product name: Dibenzepin
Packaging: 2mg
Price: $139.9
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21524
Product name: Dibenzepin
Packaging: 5mg
Price: $254.4
Updated: 2021/12/16

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Dibenzepin Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Noveril ,Wander,Switz.,1965

Uses

Antidepressant

Definition

ChEBI: 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone is a dibenzodiazepine.

Manufacturing Process

4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane. After adding a concentrated benzenic solution of β-dimethylamino-ethyl chloride freshly prepared from 3.75 grams of the hydrochloride with concentrated sodium hydroxide solution, taking up in benzene and drying the solution with potash, the mixture was boiled for 16 hours under reflux, whereupon the reaction mixture was concentrated to dryness and the residue distributed between ether and water. By exhaustive extraction of the basic fractions with dilute acetic acid, precipitation with ammonia, taking up the base in ether and working up the ethereal solution, there was obtained 5.05 grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11- dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous yellowish resin with the boiling point 185°C/0.01mm Hg. The base was crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of the monohydrochloride (from ethanol-ether) 234°-240°C.

Therapeutic Function

Psychostimulant

Dibenzepin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dibenzepin Suppliers

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4498-32-2, DibenzepinRelated Search:

Propyphenazone 2,2-DI-N-PROPYLACETAMIDE Gabapentin 5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE DIBENZEPINE HCL N-(2-aminophenyl)-N-methyl-N-phenylamine Dibenzepin

10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one

5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine

HF 1927

Dibenzepin

10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one

10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one

5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one

4498-32-12

5-(2-dimethylaminoethyl)-11-methyl-benzo[b][1,4]benzodiazepin-6-one

5-(2-dimethylaminoethyl)-11-methylbenzo[b][1,4]benzodiazepin-6-one

11H-Dibenzo[b,e][1,4]diazepin-11-one, 10-[2-(dimethylamino)ethyl]-5,10-dihydro-5-methyl-

4498-32-2

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