ChemicalBook > CAS DataBase List >  4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

Product Name
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
CAS No.
143782-23-4
Chemical Name
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
Synonyms
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile;EZ-S3;D3-EZ-S2;4-Isothiocyanato-2;Enzalutamide Impurity Z;Enzalutamide Impurity 21;Enzalutamide Impurity N7;Enzalutamide intermediate;-Fluoro-4-methylphenylisothiocyanate;4-isothiocyano-2 -(trixenon methyl) benzol
CBNumber
CB21107300
Molecular Formula
C9H3F3N2S
Formula Weight
228.19
MOL File
143782-23-4.mol
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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Property

Melting point:
39.0 to 43.0 °C
Boiling point:
331℃
Density 
1.31
Flash point:
154℃
storage temp. 
Inert atmosphere, 2-8°C
solubility 
Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
form 
powder to lump
color 
White to Yellow to Green
Stability:
Hygroscopic, Moisture sensitive
InChI
InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
InChIKey
TYXKOMAQTWRDCR-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
CAS DataBase Reference
143782-23-4
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Safety

HS Code 
2929100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
I0987
Product name
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
Purity
>98.0%(GC)
Packaging
1g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
I0987
Product name
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$201
Updated
2024/03/01
TRC
Product number
C987640
Product name
4-Cyano-3-trifluoromethylphenylisothiocyanate
Packaging
10g
Price
$1260
Updated
2021/12/16
Matrix Scientific
Product number
120962
Product name
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
Purity
97%
Packaging
250g
Price
$1980
Updated
2021/12/16
Matrix Scientific
Product number
120962
Product name
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
Purity
97%
Packaging
500g
Price
$2880
Updated
2021/12/16
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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties,Usage,Production

Uses

4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.

Uses

4-Cyano-3-trifluoromethylphenylisothiocyanate is an reagent used in the synthesis of thioxoimidazolidinones as potential anti-prostate cancer agents.

Synthesis


4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Suppliers

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View Lastest Price from 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 143782-23-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-16
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 143782-23-4
Price
US $990.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
Wuhan Cell Pharmaceutical Co., Ltd
Product
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile 143782-23-4
Price
US $3.20-266.00/g
Min. Order
1g
Purity
99%
Supply Ability
10kg
Release date
2023-03-30

143782-23-4, 4-isothiocyanato-2-(trifluoroMethyl)benzonitrileRelated Search:

2,2-Dimethyl-1,3-propanediol FLUCYTHRINATE Cyfluthrin 2,4-DICHLOROPHENYL CHLOROTHIOFORMATE 3,5-DIMETHYLPHENYL CHLOROTHIOFORMATE PENTAFLUOROPHENYL CHLOROTHIONOFORMATE Phenyl chlorothionocarbonate CHLOROCARBONYLSULFENYL CHLORIDE 1,4-PHENYLENE DIISOTHIOCYANATE o-5,6,7,8-Tetrahydro-2-naphtylthiochloroformate 2-BROMO-4-FLUOROPHENYL CHLOROTHIOFORMATE 4-(trifluoromethoxy)phenyl chlorothioformate methyl 4-(chlorocarbonothioyloxy)benzoate 4-CHLOROPHENYL CHLOROTHIONOFORMATE 4-amino-2-fluoro-N-methylbenzamide 4-Bromo-2-fluoro-N-methylbenzamide 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7

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  • Benzonitrile,4-isothiocyanato-2-(trifluoroMethyl)-
  • 3. 4-Isothiocyanato-2-(trifluoroMethyl)benzonitrile
  • 4-cyano-3-trifluoromenthylphenylisothiocyanate
  • 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile,Enzalutamide intermediate
  • 4-isothiocyananto-2-(trifluoromethyl) benzonitrile
  • 4-Isothiocyanato-2
  • Isothiocyanato-2-(trifluoromethyl)benzonitrile
  • 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE (CAS : 143782-23-4) (intermediate of Enzalutamide)
  • 4-isothiocyanoyl-2 - (trifluoromethyl) benzonitrile
  • Enzalutamide Impurity 21
  • Isothiocyanic Acid 4-Cyano-3-(trifluoromethyl)phenyl Ester
  • 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE/4-CYANO-3-TRIFLUOROMETHYLPHENYLISOTHIOCYANATE /CAS NO: 143782-23-4
  • Enzalutamide intermediate
  • Enzalutamide Impurity Z
  • Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzeneQ: What is Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the CAS Number of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the storage condition of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What are the applications of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene
  • 4-isothiocyano-2 - (trifluoromethyl) benzonitrile
  • EZ-S3
  • 4-isothiolamino-2-(trifluoromethyl)benzene Melonitrile
  • -Fluoro-4-methylphenylisothiocyanate
  • 4-Cyano-3-(trifluoromethyl)phenylIsothiocyanate,98%
  • 4-isothiocyano-2 -(trixenon methyl) benzol
  • Enzalutamide Impurity N7
  • 4-cyano-3-trifluoromenthylphenylisothiocyaChemicalbooknate
  • 4-Isothiocvanato-2-(trifluoromethyl)benzonitrile
  • D3-EZ-S2
  • 143782-23-4
  • 123782-23-4
  • 143782-23-4