4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
- Product Name
- 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
- CAS No.
- 143782-23-4
- Chemical Name
- 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
- Synonyms
- 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile;EZ-S3;D3-EZ-S2;4-Isothiocyanato-2;Enzalutamide Impurity Z;Enzalutamide Impurity 21;Enzalutamide Impurity N7;Enzalutamide intermediate;-Fluoro-4-methylphenylisothiocyanate;4-isothiocyano-2 -(trixenon methyl) benzol
- CBNumber
- CB21107300
- Molecular Formula
- C9H3F3N2S
- Formula Weight
- 228.19
- MOL File
- 143782-23-4.mol
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Property
- Melting point:
- 39.0 to 43.0 °C
- Boiling point:
- 331℃
- Density
- 1.31
- Flash point:
- 154℃
- storage temp.
- Inert atmosphere, 2-8°C
- solubility
- Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
- form
- powder to lump
- color
- White to Yellow to Green
- Stability:
- Hygroscopic, Moisture sensitive
- InChI
- InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
- InChIKey
- TYXKOMAQTWRDCR-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
- CAS DataBase Reference
- 143782-23-4
Safety
- HS Code
- 2929100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I0987
- Product name
- 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- I0987
- Product name
- 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $201
- Updated
- 2024/03/01
- Product number
- C987640
- Product name
- 4-Cyano-3-trifluoromethylphenylisothiocyanate
- Packaging
- 10g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- J53800
- Product name
- 4-Cyano-3-(trifluoromethyl)phenylisothiocyanate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 7849-3-01
- Product name
- 4-Cyano-3-(trifluoromethyl)phenyl isothiocyanate
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties,Usage,Production
Uses
4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.
Uses
4-Cyano-3-trifluoromethylphenylisothiocyanate is an reagent used in the synthesis of thioxoimidazolidinones as potential anti-prostate cancer agents.
Synthesis
4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile manufacturers
- Product
- 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 143782-23-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-16
- Product
- 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 143782-23-4
- Price
- US $990.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-19
- Product
- 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile 143782-23-4
- Price
- US $3.20-266.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2023-03-30