N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
Uses- Product Name
- N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
- CAS No.
- 208167-83-3
- Chemical Name
- N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt
- Synonyms
- tert-Butyl 4-(2-chloroethyl);1-Boc-4-(2-chloroethyl)piperazine;N-Boc-N'-(2-Chloroethyl)piperazine;1-Boc-4-(2-chloroethyl)piperazine,97%;1-Boc-4-(2-chloroethyl)piperazine, 97%;N-BOC-N''-(2-CHLOROETHYL)PIPERAZINE HYDROCHLORIDE;tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate;N-BOC-Nzzhlxy-(2-Chloroethyl)piperazine hydrochloride;N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt;tert-Butyl 4-(2-chloroethyl)tetrahydropyrazine-1-carboxylate
- CBNumber
- CB21122356
- Molecular Formula
- C11H21ClN2O2
- Formula Weight
- 248.75
- MOL File
- 208167-83-3.mol
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Property
- Melting point:
- 67-69°C
- Boiling point:
- 318.4±37.0 °C(Predicted)
- Density
- 1.106±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Slightly Soluble (7.2 g/L) (25°C).
- form
- Crystalline Powder
- pka
- 6.13±0.10(Predicted)
- color
- White to light brown
- InChI
- InChI=1S/C11H21ClN2O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9H2,1-3H3
- InChIKey
- MYOWELLYEZMECA-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(CCCl)CC1
- CAS DataBase Reference
- 208167-83-3
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B807083
- Product name
- tert-Butyl4-(2-Chloroethyl)piperazine-1-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 046534
- Product name
- TERT-BUTYL 4-(2-CHLOROETHYL)PIPERAZINE-1-CARBOXYLATE
- Purity
- >95%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR15245
- Product name
- 4-(2-Chloroethyl)piperazine,N1-BOCprotected
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 4H56-5-Q4
- Product name
- 4-(2-Chloroethyl)piperazine, N1-Boc protected
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 046534
- Product name
- TERT-BUTYL 4-(2-CHLOROETHYL)PIPERAZINE-1-CARBOXYLATE
- Purity
- >95%
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Chemical Properties,Usage,Production
Uses
tert-Butyl 4-(2-Chloroethyl)piperazine-1-carboxylate is used in a study of anticancer activity of dihydroxyanthrathiazolediones.
Uses
By the direct condensation of chloroalkyl piperazine, nitrogen mustard benzaldehyde, and pyrrole anticancer activity to bel-7404 liver cancer cells was found.
Synthesis
107-04-0
57260-71-6
208167-83-3
General procedure for the synthesis of 1-BOC-4-(2-chloroethyl)piperazine from 1-bromo-2-chloroethane and N-BOC-piperazine: firstly, di-tert-butyl dicarbonate (18.98g, 87.07mmol) was added slowly and dropwise to the suspension of dipiperazine (30.00g, 348.27mmol) and sodium carbonate (106g, 348.27mmol) in dichloromethane (200ml) 87.07 mmol) in dichloromethane solution (30 ml), the titration process lasted for 1 hour and the reaction was carried out at room temperature. After completion of the dropwise addition, the reaction mixture was stirred at room temperature overnight. At the end of the reaction, the mixture was mixed with water (100 ml) and the organic phase was separated. The organic layer was dried with magnesium sulfate followed by evaporation under reduced pressure to remove the solvent. The residue was dissolved in dichloromethane (150 ml) and sodium carbonate (15.55 g, 146.77 mmol) and 1-bromo-2-chloroethane (21.05 g, 146.77 mmol) were added. The mixture was stirred at room temperature for one weekend. After completion of the reaction, the mixture was again mixed with water (100 ml) and the organic phase was separated. The organic layer was dried with magnesium sulfate and evaporated under reduced pressure to remove the solvent. Finally, the residue was purified by silica gel column chromatography using hexane and ethyl acetate as eluents to give 6.85 g of 1-Boc-4-(2-chloroethyl)piperazine.
References
[1] Patent: WO2014/145686, 2014, A2. Location in patent: Paragraph 0382-0383
[2] RSC Advances, 2015, vol. 5, # 125, p. 103172 - 103183
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Preparation Products And Raw materials
Raw materials
Preparation Products
N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt Suppliers
- Tel
- +1-858-6993322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 21193
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@synthonix.com
- Country
- United States
- ProdList
- 6872
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
- Tel
- --
- Fax
- --
- info@synquestlabs.com
- Country
- United States
- ProdList
- 6871
- Advantage
- 62
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80
- Tel
- --
- Fax
- --
- ryan.reichlyn@ryansci.com
- Country
- United States
- ProdList
- 6439
- Advantage
- 60
View Lastest Price from N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt manufacturers
- Product
- N-Boc-N’-(2-Chloroethyl)piperazine, hydrochloride salt 208167-83-3
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10