N-Aminoethylpiperazine Property

Melting point:

-19 °C

Boiling point:

218-222 °C(lit.)

Density 

0.985 g/mL at 25 °C(lit.)

vapor density 

4.4 (vs air)

vapor pressure 

0.05 mm Hg ( 20 °C)

refractive index 

n20/D 1.500

Flash point:

200 °F

storage temp. 

Store below +30°C.

solubility 

>1000g/l

form 

Liquid

pka

10.11±0.10(Predicted)

color 

Clear colorless to slightly yellow

PH

12 (100g/l, H2O, 20℃)

explosive limit

2.1-10.5%(V)

Water Solubility 

soluble

Sensitive 

Air Sensitive

BRN 

104363

Stability:

Stable. Flammable. Incompatible with acids, acid anhydrides, acid chlorides, strong oxidizing agents, chloroformates.

LogP

-1.48 at 20℃

CAS DataBase Reference

140-31-8(CAS DataBase Reference)

NIST Chemistry Reference

N-(2-Aminoethyl)piperazine(140-31-8)

EPA Substance Registry System

1-Piperazineethanamine (140-31-8)

Safety

Hazard Codes 

C

Risk Statements 

21/22-34-43-52/53

Safety Statements 

26-36/37/39-45-61

RIDADR 

UN 2815 8/PG 3

WGK Germany 

2

RTECS 

TK8050000

Autoignition Temperature

315 °C

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29335995

Hazardous Substances Data

140-31-8(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 1470 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N-Aminoethylpiperazine Chemical Properties,Usage,Production

Chemical Properties

N-Aminoethypiperazine is a combustible and corrosive aliphatic amine. It is a colorless to light yellow viscous liquid.

Uses

1-(2-Aminoethyl)piperazine is utilized in a variety of reactions for studying corrosion inhibition, biological activity and metal ligand effects on catalysis. It is used for epoxy curing, surface activation, and as an asphalt additive. It is used in lube oil and fuel additives, mineral processing aids, polyamide resins, urethane chemicals, wet strength resins.

Uses

Used for studying corrosion inhibition

Definition

An amine combining a primary, secondary, and ter- tiary amine in one molecule.

Preparation

he synthesis of N-(2-aminoethyl) piperazine from PZ and MEA in the presence of CO2 was conducted using a method similar to that of thermal degradation experiments. 7 m PZ/2 m MEA with 0.3 mol CO2 /mol alkalinity was placed in ?-inch OD 316 stainless steel thermal cylinders , which were then sealed and placed in a convection oven held at 150 °C. Cylinders were removed periodically and samples were analyzed using ion chromatography.

General Description

N-aminoethylpiperazine appears as a colorless liquid with a faint fishlike odor. Flash point 199 °F. Corrosive to tissue. Toxic oxides of nitrogen are produced by combustion.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-Aminoethylpiperazine neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Hazard

Strong irritant to tissue.

Health Hazard

INHALATION: Burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. EYES AND SKIN: Extremely destructive to mucous membranes, upper respiratory tract, eyes and skin. Causes burns on short contact.

Fire Hazard

Special Hazards of Combustion Products: Toxic fumes of NO x

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. A skin and eye irritant. Mutation data reported. See also AMINES. Moderately flammable when exposed to heat, flame, sparks, or powerful oxidlzers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Used as an epoxy curing agent and making pharmaceuticals; synthetic fibers, and other chemicals.

Shipping

UN2815 N-Aminoethylpiperazined, Hazard class: 8; Labels: 8-Corrosive material

Incompatibilities

Solution is a strong base. Reacts with nitrosating agents (e.g., nitrites, nitrous gases, nitrous acid); capable of releasing carcinogenic nitrosamines. Incompatible with nonoxidizing mineral acids; strong acids; organic acids, acid chlorides; acid anhydrides; organic anhydrides; isocyanates, chloroformates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution; strong oxidizers. Contact with copper alloys, zinc or galvanized steel may cause violent reaction.

References

[1] YANG DU. Aqueous Piperazine/N-(2-Aminoethyl) Piperazine for CO2 Capture☆[J]. Energy Procedia, 2013, 29 1: 1621-1638. DOI:10.1016/J.EGYPRO.2013.06.038.
[2] SHI L, WANG T Y, CHEN M J, et al. Synthesis of Aminoethylpiperazine/Formaldehyde Modified Lignin Amine Asphalt Emulsifier and Its Investigation by Online FTIR Spectrophotometry[C]. 2016: 0. DOI:10.2991/ICMSE-16.2016.23.
[3] XIAOHUI HAN . Synthesis, crystal structure, and optical property of a one-dimensional selenidostannate: [AEPPH2]2[Sn5Se12] (AEPP=N-aminoethylpiperazine)[J]. Inorganic Chemistry Communications, 2016, 63: Pages 42-47. DOI:10.1016/j.inoche.2015.11.009.