Ethyl 1-aminocyclopropanecarboxylate hydrochloride
- Product Name
- Ethyl 1-aminocyclopropanecarboxylate hydrochloride
- CAS No.
- 42303-42-4
- Chemical Name
- Ethyl 1-aminocyclopropanecarboxylate hydrochloride
- Synonyms
- Ethyl 1-aminocyclopropane-1-carboxylate hydrochloride;H-ACPC-OET hydrochloride;ACPC-OEt HCl;ACPC-OMe HCl;H-AC3C-OET HCL;H-ACPC-OET HCL;H-CAIB-OET HCL;H-(1)NHCPROPN-OET HCL;H-AC3C-OEt Hydrochloride;H-ACPC-OET HCL USP/EP/BP
- CBNumber
- CB2125837
- Molecular Formula
- C6H12ClNO2
- Formula Weight
- 165.62
- MOL File
- 42303-42-4.mol
Ethyl 1-aminocyclopropanecarboxylate hydrochloride Property
- Melting point:
- gt. 110.0 and le 118.0 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- Crystalline Powder
- color
- White
- CAS DataBase Reference
- 42303-42-4
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-38-36/37-24/25-22-7/9-36/37/39
- WGK Germany
- 3
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- MNO000004
- Product name
- Ethyl 1-aminocyclopropanecarboxylate hydrochloride
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $42.8
- Updated
- 2025/07/31
- Product number
- 728934
- Product name
- Ethyl 1-aminocyclopropanecarboxylate hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $60.01
- Updated
- 2025/07/31
- Product number
- E0937
- Product name
- Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- E0937
- Product name
- Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- E899835
- Product name
- Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
Ethyl 1-aminocyclopropanecarboxylate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
64-17-5
22059-21-8
42303-42-4
Thionyl chloride (150 mL, 2.056 mol) was slowly added to a suspension of 1-aminocyclopropanecarboxylic acid (100 g, 0.989 mol) in anhydrous ethanol (1 L) below 0 °C. The reaction mixture was stirred at 70 °C for 20 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: methanol, Rf = 0.4) to confirm that most of the raw materials had been consumed. Upon completion of the reaction, the solution was concentrated to give 210 g of crude product. The residue was dissolved in water and the pH was adjusted to 9-10 with potassium carbonate.Subsequently, the aqueous layer was extracted with dichloromethane (1L x 3). The organic layers were combined and concentrated to dryness. The residue was dissolved in ethyl acetate (300 mL) and a hydrochloride solution of ethyl hydrochloride (250 mL, 4 M) was slowly added at below -30°C. The mixture was stirred at 0 °C for 30 min, during which time a solid precipitated. Filtration under nitrogen protection gave ethyl 1-aminocyclopropane-1-carboxylate hydrochloride (132 g, 80.6% yield) as a white solid. The 1H-NMR data of the free amine were as follows (400 MHz, chloroform-d): δ[ppm] = 0.91-1.02 (m, 2H), 1.15-1.30 (m, 5H), 2.17 (s, 2H), 4.10 (d, 2H).
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 1840 - 1846
[2] Patent: WO2014/147021, 2014, A2. Location in patent: Page/Page column 129
[3] Patent: WO2015/140195, 2015, A1. Location in patent: Page/Page column 92; 93
[4] Patent: US2006/25589, 2006, A1. Location in patent: Page/Page column 9
Ethyl 1-aminocyclopropanecarboxylate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 1-aminocyclopropanecarboxylate hydrochloride Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from Ethyl 1-aminocyclopropanecarboxylate hydrochloride manufacturers
- Product
- 1-Aminocyclopropane-1-carboxylic acid ethyl ester hydrochloride 42303-42-4
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- H-ACPC-OET HCL 42303-42-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08