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3-PYRIDYLACETONITRILE

Product Name
3-PYRIDYLACETONITRILE
CAS No.
6443-85-2
Chemical Name
3-PYRIDYLACETONITRILE
Synonyms
PYRIDINE-3-ACETONITRILE;NSC 83226;3-PYRIDYLACETONITRILE;3-PYRIDINEACETONITRILE;3-Pyridinylacetonitrile;3-(CYANOMETHYL)PYRIDINE;3-PYRIDYLMETHYL CYANIDE;3-Pyridylacetonitrile 98%;2-(3-pyridyl)acetonitrile;3-Pyridineacetonitrile>
CBNumber
CB2126081
Molecular Formula
C7H6N2
Formula Weight
118.14
MOL File
6443-85-2.mol
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3-PYRIDYLACETONITRILE Property

Melting point:
99-100 °C
Boiling point:
101-109 °C/1.5 mmHg (lit.)
Density 
1.108 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.529(lit.)
Flash point:
209 °F
storage temp. 
2-8°C
form 
Liquid
pka
4.17±0.10(Predicted)
color 
very deep yellow
Water Solubility 
Soluble in alcohol, ether, ketone. Insoluble in water.
BRN 
111292
InChI
InChI=1S/C7H6N2/c8-4-3-7-2-1-5-9-6-7/h1-2,5-6H,3H2
InChIKey
OIPHWUPMXHQWLR-UHFFFAOYSA-N
SMILES
C1=NC=CC=C1CC#N
CAS DataBase Reference
6443-85-2(CAS DataBase Reference)
EPA Substance Registry System
3-Pyridineacetonitrile (6443-85-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38-36/37/38
Safety Statements 
26-36
RIDADR 
3276
WGK Germany 
3
F 
10
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P66009
Product name
3-Pyridylacetonitrile
Purity
98%
Packaging
5g
Price
$83.7
Updated
2025/07/31
Sigma-Aldrich
Product number
P66009
Product name
3-Pyridylacetonitrile
Purity
98%
Packaging
25g
Price
$389
Updated
2025/07/31
TCI Chemical
Product number
P1232
Product name
3-Pyridineacetonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$94
Updated
2025/07/31
TCI Chemical
Product number
P1232
Product name
3-Pyridineacetonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$336
Updated
2025/07/31
TRC
Product number
P991830
Product name
3-Pyridineacetonitrile
Packaging
5G
Price
$85
Updated
2021/12/16
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3-PYRIDYLACETONITRILE Chemical Properties,Usage,Production

Uses

3-Pyridineacetonitrile is a reactant used in the preparation of 1,7-naphthyridine derivatives as phosphodiesterase-4 inhibitors.

Synthesis

3724-16-1

6443-85-2

The general procedure for synthesizing 3-pyridylacetonitrile from pyridine-3-acetamide is as follows: general method: after completing the preparation of the amide intermediate, the operation of Example A is carried out. Decide the state of the reaction vessel according to the relationship between the boiling point of the amide intermediate at atmospheric pressure and the reaction temperature TB: if the boiling point of the amide intermediate is equal to or lower than TB, close the reaction vessel; if higher than TB, keep the reaction vessel open. Start the stirrer, set the speed to 600 rpm, adjust the reaction temperature to TB and maintain this temperature for TD hours until the reaction is essentially complete. Subsequently, the reaction vessel was sealed and connected to a vacuum pump, the system vacuum was adjusted to 20-50 mbar (depending on the nature of the nitrile product), and the distillate was collected as the target nitrile product. The yield of the product was calculated and samples were taken for NMR and elemental analysis to characterize the structure and purity of the resulting nitrile product. The specific reaction conditions and characterization results are detailed in Tables A-7 to A-12 below. the characterization data confirmed that the resulting nitrile products were of very high purity (>99%). In this series of examples for the preparation of the nitrile product, it is recommended to add 10 g of phosphorus pentoxide as a catalyst at once at the beginning of the reaction.

References

[1] Patent: CN104557610, 2018, B. Location in patent: Paragraph 0153; 0154; 0155; 0158; 0159
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 1988
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 5752,5756

3-PYRIDYLACETONITRILE Preparation Products And Raw materials

Raw materials

3-(Chloromethyl)pyridine

Preparation Products

3-Pyridylacetic acid hydrochloride Xanomeline
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View Lastest Price from 3-PYRIDYLACETONITRILE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-PYRIDYLACETONITRILE 6443-85-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-19
Dideu Industries Group Limited
Product
3-PYRIDYLACETONITRILE 6443-85-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26
Career Henan Chemical Co
Product
3,4,5-Trifluorobenzoic acid 6443-85-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2020-01-09

6443-85-2, 3-PYRIDYLACETONITRILERelated Search:

2-Pyridylacetonitrile ,97%,2-PYRIDYLACETONITRILE 3-PYRIDYLACETONITRILE 2-Chloro-5-pyridineacetonitrile 4-PYRIDYLACETONITRILE HYDROCHLORIDE,4-PYRIDYLACETONITRILE MONOHYDROCHLORIDE,4-PYRIDYLACETONITRILE HCL,4-Pyridylacetonitrile HCl Salt 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2-PYRIDINYL)ACETONITRILE 1-Phenyl-1-(2-pyridylacetonitrile),A-PHENYL-2-PYRIDYLACETONITRILE,PHENYL-2-PYRIDYLACETONITRILE RG-13022 TYRPHOSTIN RG 14620 morpholin-4-yl(pyridin-3-yl)acetonitrile RARECHEM AK ML 0009 4,6-Dichloropyridine-3-acetonitrile 2,4,6-Trimethypyridine-3,5-diacetonitrile TYRPHOSTIN RG 13022 ETHYL 2-CYANO-2-PYRIDIN-3-YL-ACETATE 2-CYANO-3-PYRIDYLACETONITRILE RARECHEM AK ML 0015 RARECHEM AK ML 0014 (Z)-3-[4-(3-FORMYL-1H-INDOL-1-YL)PHENYL]-2-(3-PYRIDINYL)-2-PROPENENITRILE

  • PYRIDINE-3-ACETONITRILE
  • 3-PYRIDINEACETONITRILE
  • 3-PYRIDYLACETONITRILE
  • 3-PYRIDYLMETHYL CYANIDE
  • 3-(CYANOMETHYL)PYRIDINE
  • 3-Pyridinylacetonitrile
  • Pyridine-3-acetonitrile,98%
  • NSC 83226
  • 3-Pyridylacetonitrile, 98% 5GR
  • 3-(Cyanomethyl)pyridine 3-Pyridylacetonitrile
  • 3-Pyridylacetonitrile 98%
  • 2-(3-pyridyl)acetonitrile
  • 2-pyridin-3-ylethanenitrile
  • 3-(3-methoxyphenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine hydrochloride
  • 3-Pyridineacetonitrile&gt
  • 3-PYRIDYLACETONITRILE ISO 9001：2015 REACH
  • 3-Pyridineacetonitrile (6CI, 7CI, 8CI, 9CI, ACI)
  • 3-PYRIDYLACETONITRILE (5 GMS)
  • 3-Pyridylacetonitrile, 98%
  • 6443-85-2
  • Building Blocks
  • C7 and C8
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • C7 to C8
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Pyridines
  • pharmacetical
  • Boron, Nitrile, Thio,& TM-Cpds
  • Heterocycles