2-Chloro-5-pyridineacetonitrile
- Product Name
- 2-Chloro-5-pyridineacetonitrile
- CAS No.
- 39891-09-3
- Chemical Name
- 2-Chloro-5-pyridineacetonitrile
- Synonyms
- 2-Chloro-5-pyridinea;2-chloro-5-acetonitrile;oro-5-pyridineacetonitriL;2-CHLORO-5-PYRIDINEACETONITRILE;2-CHLOROPYRIDINE-5-ACETONITRILE;6-Chloro-3-pyridineacetonitrile;6-Chloro-3-(cyanomethyl)pyridine;2-CHLORO-5-(CYANOMETHYL)PYRIDINE;3-Pyridineacetonitrile, 6-chloro-;2-(6-chloropyridin-3-yl)acetonitrile
- CBNumber
- CB9450903
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 39891-09-3.mol
2-Chloro-5-pyridineacetonitrile Property
- Melting point:
- 49-54°C
- Boiling point:
- 182 °C(Press: 1 Torr)
- Density
- 1.262±0.06 g/cm3(Predicted)
- Flash point:
- >110℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -1.02±0.10(Predicted)
- Appearance
- Brown to reddish brown Solid
- InChI
- InChI=1S/C7H5ClN2/c8-7-2-1-6(3-4-9)5-10-7/h1-2,5H,3H2
- InChIKey
- BLGUCBUETMYJTB-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC=C1CC#N
- CAS DataBase Reference
- 39891-09-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- UN 3439 6.1 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT, TOXIC
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 734810
- Product name
- 2-Chloropyridine-5-acetonitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $40.97
- Updated
- 2025/07/31
- Product number
- C380763
- Product name
- 2-Chloro-5-cyanomethylpyridine
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC10678
- Product name
- 2-Chloro-5-(cyanomethyl)pyridine
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FC10678
- Product name
- 2-Chloro-5-(cyanomethyl)pyridine
- Packaging
- 25g
- Price
- $137.5
- Updated
- 2021/12/16
- Product number
- 023735
- Product name
- 2-(6-Chloro-3-pyridinyl)acetonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $143
- Updated
- 2021/12/16
2-Chloro-5-pyridineacetonitrile Chemical Properties,Usage,Production
Uses
2-Chloro-5-cyanomethylpyridine
Synthesis
773837-37-9
70258-18-3
39891-09-3
General procedure for the synthesis of 2-chloro-5-pyridylacetonitrile from 2-chloro-5-chloromethylpyridine and sodium cyanide: Step 1. Synthesis of (6-chloropyridin-3-yl)acetonitrile. To a stirred solution of 2-chloro-5-chloromethylpyridine (25 g, 0.154 mol) in ethanol (40 mL) was slowly added an aqueous solution of sodium cyanide (8.17 g, 0.167 mol) (18 mL) at 0 °C. The reaction mixture was heated to reflux for 2 hours, followed by continued stirring at room temperature for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was dissolved in water and extracted with dichloromethane (500 mL). The organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with the eluent being a 70/30 dichloromethane/hexane solvent mixture to give 20 g (85% yield) of brown oily product. The product was solidified by standing and ESI-MS m/z 153 (MH+).
References
[1] Patent: WO2010/130708, 2010, A1. Location in patent: Page/Page column 105
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2168 - 2173
[3] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 111
[4] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 221
[5] Patent: US2013/29961, 2013, A1. Location in patent: Paragraph 0705
2-Chloro-5-pyridineacetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-pyridineacetonitrile manufacturers
- Product
- 2-Chloro-5-pyridineacetonitrile 39891-09-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Chloro-5-pyridineacetonitrile 39891-09-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Chloro-5-pyridineacetonitrile 39891-09-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26