2-Chloro-5-fluoropyridine

Product Name: 2-Chloro-5-fluoropyridine
CAS No.: 31301-51-6
Chemical Name: 2-Chloro-5-fluoropyridine
Synonyms: 5-Fluoro-2-chloropyridine;2-CHLORO-5-FLUOROPYRIDINE;2-CHLORO-5-FLUOROPYPRIDINE;2-chloro-5-fluoridepyridine;2-Chloro-5-fluoropyridine98%;Pyridine, 2-chloro-5-fluoro-;2-Chloro-5-fluoropyridine >2-Chloro-5-fluoropyridine 98%;2-Chloro-5-fluoropyridine ,96%;2-Chloro-5-fluoropyridine ISO 9001：2015 REACH
CBNumber: CB4390512
Molecular Formula: C5H3ClFN
Formula Weight: 131.54
MOL File: 31301-51-6.mol

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2-Chloro-5-fluoropyridine Property

Melting point:: 19℃
Boiling point:: 74 °C / 38mmHg
Density: 1.297 g/mL at 25 °C
refractive index: n20/D 1.503
Flash point:: 108 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to lump to clear liquid
pka: -2.20±0.10(Predicted)
color: White or Colorless to Light yellow
InChI: InChI=1S/C5H3ClFN/c6-5-2-1-4(7)3-8-5/h1-3H
InChIKey: QOGXQLSFJCIDNY-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(F)C=C1
CAS DataBase Reference: 31301-51-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 10-22-37/38-41-36/37/38
Safety Statements: 26-36/39-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 643556
Product name: 2-Chloro-5-fluoropyridine
Purity: 95%
Packaging: 5g
Price: $53.16
Updated: 2025/07/31

Sigma-Aldrich

Product number: 643556
Product name: 2-Chloro-5-fluoropyridine
Purity: 95%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: C2270
Product name: 2-Chloro-5-fluoropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: C2270
Product name: 2-Chloro-5-fluoropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $57
Updated: 2025/07/31

TRC

Product number: C366765
Product name: 2-Chloro-5-fluoropyridine
Packaging: 2.5g
Price: $140
Updated: 2021/12/16

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2-Chloro-5-fluoropyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

2-Chloro-5-fluoropyridine, is the intermediate used for the synthesis of pharmaceuticals agents and biologically active compounds, such as pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

Synthesis

5350-93-6

31301-51-6

The general procedure for the synthesis of 2-chloro-5-fluoropyridine from 2-chloro-5-aminopyridine is as follows: in a 25-mL three-necked flask equipped with a reflux condenser, thermocouple, and stirring system, 1 g (7.78 mmol) of 2-chloro-5-aminopyridine was dissolved in 14.3 g of o-dichlorobenzene, and added dropwise over a 5-min period of 5 min at room temperature to 1.64 g (11.5 mmol, 1.47 molar equivalents) of the boron trifluoride ethyl ether complex. Upon completion of the dropwise addition, the reaction solution was beige in color and accompanied by the formation of a precipitate. Subsequently, the reaction system was heated to 105 °C and maintained for 20 minutes before 1.05 g (9.2 mmol, 1.18 mole equivalents, 90% purity) of tert-butyl nitrite was added to 5.0 g of o-dichlorobenzene at a controlled titration rate of 25 ml/hr. The reaction was kept at 105 °C and continued for 25 min, after which the heating was stopped. The yield of 2-chloro-5-fluoropyridine was 36% as determined by 19F NMR.

References

[1] Patent: US2007/276168, 2007, A1. Location in patent: Page/Page column 9

2-Chloro-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Heptane 5-Amino-2-chloropyridine Isoamyl nitrite Fluoroboric acid

Preparation Products

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2-Chloro-5-fluoropyridine Suppliers

Americas 1 China 293 Europe 3 France 2 Germany 7 India 16 Italy 1 Japan 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 19 United States 46 Global 394

Ningbo Fuhe Chemical Co., Ltd.

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Beijing DeLee Pharma Technology Co.,Ltd.

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Liaoning Tianhua Chemical Co., Ltd.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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View Lastest Price from 2-Chloro-5-fluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-5-fluoropyridine 31301-51-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-5-fluoropyridine 31301-51-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Chloro-5-fluoropyridine 31301-51-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

31301-51-6, 2-Chloro-5-fluoropyridineRelated Search:

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2-CHLORO-5-FLUOROPYRIDINE

2-Chloro-5-fluoropyridine 98%

2-Chloro-5-fluoropyridine98%

2-Chloro-5-fluoropyridine ,96%

2-chloro-5-fluoridepyridine

5-Fluoro-2-chloropyridine

2-CHLORO-5-FLUOROPYPRIDINE

Pyridine, 2-chloro-5-fluoro-

2-Chloro-5-fluoropyridine &gt

2-Chloro-5-fluoropyridine ISO 9001：2015 REACH

31301-51-6

1071-71-9

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

Building Blocks

Pyridines derivates

Chloropyridines

Fluoropyridines

Halopyridines

Pyridine

pyridine derivative

Pyridines, Pyrimidines, Purines and Pteredines

Boronic Acid

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Variety of halogenated heterocyclic series

Fluorin-contained pyridine series

Fluorine series

Building Blocks

C5

C5 to C6

Chemical Synthesis

Fluorinated Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocyclic Fluorinated Building Blocks

Other Fluorinated Heterocycles

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