3-PYRIDYLACETONITRILE
- Product Name
- 3-PYRIDYLACETONITRILE
- CAS No.
- 6443-85-2
- Chemical Name
- 3-PYRIDYLACETONITRILE
- Synonyms
- PYRIDINE-3-ACETONITRILE;NSC 83226;3-PYRIDYLACETONITRILE;3-PYRIDINEACETONITRILE;3-Pyridinylacetonitrile;3-(CYANOMETHYL)PYRIDINE;3-PYRIDYLMETHYL CYANIDE;3-Pyridylacetonitrile 98%;2-(3-pyridyl)acetonitrile;3-Pyridineacetonitrile>
- CBNumber
- CB2126081
- Molecular Formula
- C7H6N2
- Formula Weight
- 118.14
- MOL File
- 6443-85-2.mol
3-PYRIDYLACETONITRILE Property
- Melting point:
- 99-100 °C
- Boiling point:
- 101-109 °C/1.5 mmHg (lit.)
- Density
- 1.108 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.529(lit.)
- Flash point:
- 209 °F
- storage temp.
- 2-8°C
- form
- Liquid
- pka
- 4.17±0.10(Predicted)
- color
- very deep yellow
- Water Solubility
- Soluble in alcohol, ether, ketone. Insoluble in water.
- BRN
- 111292
- InChI
- InChI=1S/C7H6N2/c8-4-3-7-2-1-5-9-6-7/h1-2,5-6H,3H2
- InChIKey
- OIPHWUPMXHQWLR-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1CC#N
- CAS DataBase Reference
- 6443-85-2(CAS DataBase Reference)
- EPA Substance Registry System
- 3-Pyridineacetonitrile (6443-85-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38-36/37/38
- Safety Statements
- 26-36
- RIDADR
- 3276
- WGK Germany
- 3
- F
- 10
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- P66009
- Product name
- 3-Pyridylacetonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $83.7
- Updated
- 2025/07/31
- Product number
- P66009
- Product name
- 3-Pyridylacetonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $389
- Updated
- 2025/07/31
- Product number
- P1232
- Product name
- 3-Pyridineacetonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $94
- Updated
- 2025/07/31
- Product number
- P1232
- Product name
- 3-Pyridineacetonitrile
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $336
- Updated
- 2025/07/31
- Product number
- P991830
- Product name
- 3-Pyridineacetonitrile
- Packaging
- 5G
- Price
- $85
- Updated
- 2021/12/16
3-PYRIDYLACETONITRILE Chemical Properties,Usage,Production
Uses
3-Pyridineacetonitrile is a reactant used in the preparation of 1,7-naphthyridine derivatives as phosphodiesterase-4 inhibitors.
Synthesis
3724-16-1
6443-85-2
The general procedure for synthesizing 3-pyridylacetonitrile from pyridine-3-acetamide is as follows: general method: after completing the preparation of the amide intermediate, the operation of Example A is carried out. Decide the state of the reaction vessel according to the relationship between the boiling point of the amide intermediate at atmospheric pressure and the reaction temperature TB: if the boiling point of the amide intermediate is equal to or lower than TB, close the reaction vessel; if higher than TB, keep the reaction vessel open. Start the stirrer, set the speed to 600 rpm, adjust the reaction temperature to TB and maintain this temperature for TD hours until the reaction is essentially complete. Subsequently, the reaction vessel was sealed and connected to a vacuum pump, the system vacuum was adjusted to 20-50 mbar (depending on the nature of the nitrile product), and the distillate was collected as the target nitrile product. The yield of the product was calculated and samples were taken for NMR and elemental analysis to characterize the structure and purity of the resulting nitrile product. The specific reaction conditions and characterization results are detailed in Tables A-7 to A-12 below. the characterization data confirmed that the resulting nitrile products were of very high purity (>99%). In this series of examples for the preparation of the nitrile product, it is recommended to add 10 g of phosphorus pentoxide as a catalyst at once at the beginning of the reaction.
References
[1] Patent: CN104557610, 2018, B. Location in patent: Paragraph 0153; 0154; 0155; 0158; 0159
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 1988
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 5752,5756
3-PYRIDYLACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
3-PYRIDYLACETONITRILE Suppliers
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View Lastest Price from 3-PYRIDYLACETONITRILE manufacturers
- Product
- 3-PYRIDYLACETONITRILE 6443-85-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-19
- Product
- 3-PYRIDYLACETONITRILE 6443-85-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 3,4,5-Trifluorobenzoic acid 6443-85-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-09