(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid

Product Name: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
CAS No.: 334769-80-1
Chemical Name: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
Synonyms: (2S,5S)-1-(tert-Butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid;EOS-60522;GS-5817 interMediate;Boc-cis-5-methyl-Pro-OH;(2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic aci;(2s,5s)-n-boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-1-Boc-5-methylpyrrolidine-2-carboxylic Acid;cis-5-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
CBNumber: CB21267594
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 334769-80-1.mol

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(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Property

Boiling point:: 343.2±35.0 °C(Predicted)
Density: 1.150
storage temp.: 2-8°C
pka: 4.02±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-D0422
Product name: (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
Purity: ≥97.0%
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152064
Product name: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
Packaging: 500mg
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152064
Product name: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
Packaging: 1g
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-D0422
Product name: (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
Purity: ≥97.0%
Packaging: 5g
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152064
Product name: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
Packaging: 2g
Price: $360
Updated: 2021/12/16

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(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production

Synthesis

676560-83-1

334769-80-1

The general procedure for the synthesis of (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid from the compound (CAS: 676560-83-1) is as follows: 1. ethyl (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylate (6.46 g, 25.1 mmol) was dissolved in ethanol (20 mL). 2. Lithium hydroxide monohydrate (2.11 g, 50.2 mmol) and deionized water (12 mL) were added to the above solution. 3. The reaction mixture was stirred at room temperature for 16 hours. 4. 4. Upon completion of the reaction, the mixture was partitioned between ethyl acetate and a 1:1 mixture of saturated aqueous sodium chloride solution and 1N hydrochloric acid. 5. The aqueous layer was separated and extracted again with ethyl acetate. 6. Combine all organic layers and dry with anhydrous sodium sulfate. 7. Vacuum removal of the solvent afforded (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid as a white solid (quantitative yield), which was used directly in the next reaction without further purification.

References

[1] Patent: US2014/178336, 2014, A1. Location in patent: Paragraph 0252
[2] Patent: US2015/361087, 2015, A1. Location in patent: Paragraph 0311; 0316
[3] Patent: WO2015/110048, 2015, A1. Location in patent: Paragraph 00165
[4] Patent: US2017/44140, 2017, A1. Location in patent: Paragraph 0218; 0231; 0232; 0233
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3520 - 3535

(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials

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(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Suppliers

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View Lastest Price from (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid manufacturers

Career Henan Chemical Co

Product: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid 334769-80-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-27

334769-80-1, (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acidRelated Search:

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(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic aci

GS-5817 interMediate

2. (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)-5-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid

Boc-cis-5-methyl-Pro-OH

cis-5-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

EOS-60522

1,2-Pyrrolidinedicarboxylic acid, 5-methyl-, 1-(1,1-dimethylethyl) ester, (2S,5S)-

(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

(2s,5s)-n-boc-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)- 5-Methyl-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

(2S,5S)-1-(tert-Butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)-1-Boc-5-methylpyrrolidine-2-carboxylic Acid

334769-80-1