2-[2-(3-Methoxyphenyl)ethyl]phenol

Product Name: 2-[2-(3-Methoxyphenyl)ethyl]phenol
CAS No.: 167145-13-3
Chemical Name: 2-[2-(3-Methoxyphenyl)ethyl]phenol
Synonyms: 2-[2-(3-Methoxypheny;2-(3-MethoxyphenethyL;Shagrelate impurity 13;2-(3-methoxyphenethyl)phenol;2-(3-Methoxyphenethyl)phenol>[2-(3-Methoxyphenyl)ethyl]phenol;2-(2-(3-METHOXYPHENYL)ETHYL)PHENOL;Phenol, 2-[2-(3-methoxyphenyl)ethyl]-;2-[2-(3-METHOXYPHENYL)ETHYL]PHENOL / 167145-13-3;2-[2-(3-Methoxyphenyl)ethyl]phenol or o-(3-methoxyphenethyl)phenol
CBNumber: CB21303582
Molecular Formula: C15H16O2
Formula Weight: 228.29
MOL File: 167145-13-3.mol

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2-[2-(3-Methoxyphenyl)ethyl]phenol Property

Melting point:: 45.0 to 49.0 °C
Boiling point:: 347.6±22.0 °C(Predicted)
Density: 1.111±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 10.30±0.30(Predicted)
color: White
InChI: InChI=1S/C15H16O2/c1-17-14-7-4-5-12(11-14)9-10-13-6-2-3-8-15(13)16/h2-8,11,16H,9-10H2,1H3
InChIKey: HGQQRAXOBYWKDV-UHFFFAOYSA-N
SMILES: C1(O)=CC=CC=C1CCC1=CC=CC(OC)=C1
CAS DataBase Reference: 167145-13-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HS Code: 2907230010

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2472
Product name: 2-(3-Methoxyphenethyl)phenol
Purity: >98.0%(GC)
Packaging: 1g
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: M2472
Product name: 2-(3-Methoxyphenethyl)phenol
Purity: >98.0%(GC)
Packaging: 5g
Price: $212
Updated: 2025/07/31

TRC

Product number: M264515
Product name: 2-[2-(3-Methoxyphenyl)ethyl]phenol
Packaging: 25g
Price: $350
Updated: 2021/12/16

TRC

Product number: M264515
Product name: 2-[2-(3-Methoxyphenyl)ethyl]phenol
Packaging: 100g
Price: $625
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 59791
Product name: 2-[2-(3-Methoxyphenyl)ethyl]phenol
Packaging: 50g
Price: $585
Updated: 2021/12/16

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2-[2-(3-Methoxyphenyl)ethyl]phenol Chemical Properties,Usage,Production

Chemical Properties

Colorless or light red oily liquid

Uses

2-[2-(3-Methoxyphenyl)ethyl]phenol is an intermediate used to prepare sarpogrelate (S142300, HCl salt) analogues. Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist. It is also an antiplatelet agent.

Synthesis

1072930-86-9

167145-13-3

(1) Check the cooling system and vacuum system of the autoclave reactor to ensure that the equipment is intact. Perform a 0.3 MPa nitrogen pressure test for 1 hour, requiring a pressure drop of less than 0.05 MPa; (2) After confirming the normal state of the autoclave, add 400 g of industrial ethanol and 36 g (0.114 mol) 1-(benzyloxy)-2-(3-methoxystyryl)benzene. Stirring was initiated and 5 g (0.0035 mol) of palladium carbon catalyst was added. Open the hydrogen cylinder valve, control the pipeline pressure below 0.3 MPa, replace the nitrogen with hydrogen and repeat the process three times; (3) Increase the hydrogen pressure in the autoclave to 0.3 MPa and close the hydrogen valve. Start stirring and heating (oil or water bath), when the reaction temperature reaches about 30 °C, a pressure drop is observed, indicating the start of the hydrogenation reaction; (4) Maintain the reaction temperature at about 30 °C and the hydrogen pressure in the range of 0.1-0.3 MPa. Record the pressure and reaction temperature and time before and after each hydrogen charging; (5) After the reaction was carried out for 2 hours, the pressure drop slowed down and the reaction basically stopped. Maintaining 0.3 MPa hydrogen pressure and 30°C reaction conditions for 1 hour, the reaction was considered complete if the pressure drop was less than 0.01 MPa. At the end of the reaction, the reaction mixture was filtered (using a Brinell funnel and rapid characterization filter paper) to remove the palladium-carbon catalyst. The ethanol was concentrated at atmospheric pressure until about 90 mL remained. 26 g of an off-white solid was obtained after natural cooling, with an HPLC purity of 97.79%, a melting point of 50.2-52.4 °C, and a yield of 98.4%.

References

[1] Patent: CN107324979, 2017, A. Location in patent: Paragraph 0040; 0077; 0090-0096
[2] Chinese Chemical Letters, 2010, vol. 21, # 3, p. 287 - 289
[3] Patent: CN105906486, 2016, A. Location in patent: Paragraph 0008; 0013

2-[2-(3-Methoxyphenyl)ethyl]phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(3-Methoxyphenyl)ethyl]phenol Suppliers

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View Lastest Price from 2-[2-(3-Methoxyphenyl)ethyl]phenol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-09-24

Henan Aochuang Chemical Co.,Ltd.

Product: 2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shaanxi Dideu New Materials Co. Ltd

Product: 2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-14

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2-(2-(3-METHOXYPHENYL)ETHYL)PHENOL

Phenol, 2-[2-(3-methoxyphenyl)ethyl]-

2-[2-(3-Methoxypheny

2-(3-methoxyphenethyl)phenol

2-(3-Methoxyphenethyl)phenol&gt

2-(3-MethoxyphenethyL

2-[2-(3-METHOXYPHENYL)ETHYL]PHENOL / 167145-13-3

2-[2-(3-Methoxyphenyl)ethyl]phenol or o-(3-methoxyphenethyl)phenol

[2-(3-Methoxyphenyl)ethyl]phenol

Shagrelate impurity 13

167145-13-3

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