ChemicalBook > CAS DataBase List > 2-[2-(3-Methoxyphenyl)ethyl]phenol

2-[2-(3-Methoxyphenyl)ethyl]phenol

Product Name
2-[2-(3-Methoxyphenyl)ethyl]phenol
CAS No.
167145-13-3
Chemical Name
2-[2-(3-Methoxyphenyl)ethyl]phenol
Synonyms
2-[2-(3-Methoxypheny;2-(3-MethoxyphenethyL;Shagrelate impurity 13;2-(3-methoxyphenethyl)phenol;2-(3-Methoxyphenethyl)phenol>[2-(3-Methoxyphenyl)ethyl]phenol;2-(2-(3-METHOXYPHENYL)ETHYL)PHENOL;Phenol, 2-[2-(3-methoxyphenyl)ethyl]-;2-[2-(3-METHOXYPHENYL)ETHYL]PHENOL / 167145-13-3;2-[2-(3-Methoxyphenyl)ethyl]phenol or o-(3-methoxyphenethyl)phenol
CBNumber
CB21303582
Molecular Formula
C15H16O2
Formula Weight
228.29
MOL File
167145-13-3.mol
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2-[2-(3-Methoxyphenyl)ethyl]phenol Property

Melting point:
45.0 to 49.0 °C
Boiling point:
347.6±22.0 °C(Predicted)
Density 
1.111±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
10.30±0.30(Predicted)
color 
White
InChI
InChI=1S/C15H16O2/c1-17-14-7-4-5-12(11-14)9-10-13-6-2-3-8-15(13)16/h2-8,11,16H,9-10H2,1H3
InChIKey
HGQQRAXOBYWKDV-UHFFFAOYSA-N
SMILES
C1(O)=CC=CC=C1CCC1=CC=CC(OC)=C1
CAS DataBase Reference
167145-13-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
HS Code 
2907230010
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2472
Product name
2-(3-Methoxyphenethyl)phenol
Purity
>98.0%(GC)
Packaging
1g
Price
$71
Updated
2025/07/31
TCI Chemical
Product number
M2472
Product name
2-(3-Methoxyphenethyl)phenol
Purity
>98.0%(GC)
Packaging
5g
Price
$212
Updated
2025/07/31
TRC
Product number
M264515
Product name
2-[2-(3-Methoxyphenyl)ethyl]phenol
Packaging
25g
Price
$350
Updated
2021/12/16
TRC
Product number
M264515
Product name
2-[2-(3-Methoxyphenyl)ethyl]phenol
Packaging
100g
Price
$625
Updated
2021/12/16
AK Scientific
Product number
B914
Product name
2-(3-Methoxyphenethyl)phenol
Packaging
1g
Price
$74
Updated
2021/12/16
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2-[2-(3-Methoxyphenyl)ethyl]phenol Chemical Properties,Usage,Production

Chemical Properties

Colorless or light red oily liquid

Uses

2-[2-(3-Methoxyphenyl)ethyl]phenol is an intermediate used to prepare sarpogrelate (S142300, HCl salt) analogues. Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist. It is also an antiplatelet agent.

Synthesis

1072930-86-9

167145-13-3

(1) Check the cooling system and vacuum system of the autoclave reactor to ensure that the equipment is intact. Perform a 0.3 MPa nitrogen pressure test for 1 hour, requiring a pressure drop of less than 0.05 MPa; (2) After confirming the normal state of the autoclave, add 400 g of industrial ethanol and 36 g (0.114 mol) 1-(benzyloxy)-2-(3-methoxystyryl)benzene. Stirring was initiated and 5 g (0.0035 mol) of palladium carbon catalyst was added. Open the hydrogen cylinder valve, control the pipeline pressure below 0.3 MPa, replace the nitrogen with hydrogen and repeat the process three times; (3) Increase the hydrogen pressure in the autoclave to 0.3 MPa and close the hydrogen valve. Start stirring and heating (oil or water bath), when the reaction temperature reaches about 30 °C, a pressure drop is observed, indicating the start of the hydrogenation reaction; (4) Maintain the reaction temperature at about 30 °C and the hydrogen pressure in the range of 0.1-0.3 MPa. Record the pressure and reaction temperature and time before and after each hydrogen charging; (5) After the reaction was carried out for 2 hours, the pressure drop slowed down and the reaction basically stopped. Maintaining 0.3 MPa hydrogen pressure and 30°C reaction conditions for 1 hour, the reaction was considered complete if the pressure drop was less than 0.01 MPa. At the end of the reaction, the reaction mixture was filtered (using a Brinell funnel and rapid characterization filter paper) to remove the palladium-carbon catalyst. The ethanol was concentrated at atmospheric pressure until about 90 mL remained. 26 g of an off-white solid was obtained after natural cooling, with an HPLC purity of 97.79%, a melting point of 50.2-52.4 °C, and a yield of 98.4%.

References

[1] Patent: CN107324979, 2017, A. Location in patent: Paragraph 0040; 0077; 0090-0096
[2] Chinese Chemical Letters, 2010, vol. 21, # 3, p. 287 - 289
[3] Patent: CN105906486, 2016, A. Location in patent: Paragraph 0008; 0013

2-[2-(3-Methoxyphenyl)ethyl]phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(3-Methoxyphenyl)ethyl]phenol Suppliers

Americas 1 Canada 1 China 198 Europe 1 India 5 Japan 1 United Kingdom 1 United States 13 Global 221
Alchem Pharmtech,Inc.
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View Lastest Price from 2-[2-(3-Methoxyphenyl)ethyl]phenol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2025-09-24
Henan Aochuang Chemical Co.,Ltd.
Product
2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shaanxi Dideu New Materials Co. Ltd
Product
2-[2-(3-Methoxyphenyl)ethyl]phenol 167145-13-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-14

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