ChemicalBook > CAS DataBase List > Benidipine

Benidipine

Product Name: Benidipine
CAS No.: 105979-17-7
Chemical Name: Benidipine
Synonyms: BENIDIPINE HCL;(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride;KW-3049;5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-;CONIEL;BENIDIPINE;NACADIPINE;CAPADIPINE;Benidipene
CBNumber: CB2131201
Molecular Formula: C28H31N3O6
Formula Weight: 505.56
MOL File: 105979-17-7.mol

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Benidipine Property

Boiling point:: 625.2±55.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
pka: pKa 7.34(H2O(long extrapolation) ) (Uncertain)
Water Solubility: 316μg/L at 25℃
InChIKey: QZVNQOLPLYWLHQ-GRHWAJSLNA-N
SMILES: [C@H]1(C(C(=O)OC)=C(NC(C)=C1C(=O)O[C@@H]1CCCN(CC2=CC=CC=C2)C1)C)C1=CC=CC([N+]([O-])=O)=C1 |&1:0,14,r|
LogP: 4.61
CAS DataBase Reference: 105979-17-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B157508
Product name: racBenidipine
Packaging: 0.5mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002106
Product name: CONIEL
Purity: 95.00%
Packaging: 100MG
Price: $693
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18512
Product name: Benidipine
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002106
Product name: CONIEL
Purity: 95.00%
Packaging: 1G
Price: $1501.5
Updated: 2021/12/16

AvaChem

Product number: 3003B
Product name: Benidipine
Packaging: 100mg
Price: $89
Updated: 2021/12/16

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Benidipine Chemical Properties,Usage,Production

Uses

Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

in vivo

Benidipine (3, 5, 10 μg/kg; i.v.) shows significant anti-apoptosis effects in a haemodynamically independent manner^[2].
Benidipine (5 mg/kg; i.v.; every other day for 6 weeks) increases the activity of endothelial cell-type nitric oxide synthase (eNOS) and improves coronary circulation in hypertensive rats^[3].
Benidipine (1, 3, 10 mg/kg; p.o.; once daily for 1 week) significant cardioprotective effects against ischemia-reperfusion injury^[4].

Animal Model:	Sham MI (myocardial ischaemia)/R (ischmia reperfused injury) rabbits and MI/R rabbits^[2]
Dosage:	3, 5, 10 μg/kg
Administration:	I.v.
Result:	Caused a significant decreased in HR ( heart rate), MABP (mean arterial blood pressure), PRI (pressure-rateindex) at 10 μg/kg, decreased apoptotic positive cells to7.4% at 3 μg/kg and not significantly different from that seen in the group treated with higher dose.

Animal Model:	Renovascular hypertensive rats (RHR)^[3]
Dosage:	5 mg/kg (dissolved in peanut oil)
Administration:	I.v.; every other day for 6 weeks
Result:	Significantly decreased the blood pressure and coronary vascular resistance index, but increased nitrite production and eNOS mRNA expression and significantly increased the coronary flow at rest, the capillary density.

Animal Model:	Rats (heart model (Langendorff perfusion))^[4]
Dosage:	1, 3, 10 mg/kg
Administration:	P.o.; once daily for 1 week
Result:	Significantly increased the post-ischemic recovery of LVDP and LV dP/dt max (LVDP: 87.5±10.1 vs 64.6±11.9%; LV dP/dt max: 97.8±10.4 vs 70.2±15.7%; p<0.05) at 3 mg/kg.

Enzyme inhibitor

This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.

Benidipine Preparation Products And Raw materials

Raw materials

3,5-Pyridinedicarboxylic acid Methyl 3-aminocrotonate Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 1-Benzyl-3-piperidinol

Preparation Products

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View Lastest Price from Benidipine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Benidipine 105979-17-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Benidipine 105979-17-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Shaanxi Dideu Medichem Co. Ltd

Product: Benidipine 105979-17-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

105979-17-7, BenidipineRelated Search:

Dimethyl sulfoxide Benzyl chloride Dimethyl fumarate N,N-Dimethylformamide Benzyl isocyanate Benzyl alcohol Haloperidol Benzyltrimethylammonium chloride Benzyl nicotinate ETHANE Benzyl benzoate Chlorodimethylphenylsilane Benzyltriethylammonium chloride Diphenoxylate Benidipine hydrochloride 2-(Diethylamino)ethyl methacrylate 1-Benzyl-3-piperidinol hydrochloride Nitrendipine

(R*,R*)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel-

NACADIPINE

BENIDIPINE

BENIDIPINE HCL

CAPADIPINE

CONIEL

KW-3049

5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-(+-)-

(+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

(R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester

(4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester

(4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester

(4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester

rac Benidipine

Benidipine USP/EP/BP

RAC Benidipine D7

Benidipene

105979-17-7

C28H31N3O6HCl

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