protosappanin A
- Product Name
- protosappanin A
- CAS No.
- 102036-28-2
- Chemical Name
- protosappanin A
- Synonyms
- Sappanol B;protosappanin A;PROTOSAPPANIN A (PTA);Protosappanin A, 10 mM in DMSO;3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one;3,10,11-Trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one;6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-;Protosappanin A,inhibit,JAK,Inhibitor,STAT,Janus kinase
- CBNumber
- CB21315574
- Molecular Formula
- C15H12O5
- Formula Weight
- 272.25
- MOL File
- 102036-28-2.mol
protosappanin A Property
- Melting point:
- 254-255 °C
- Boiling point:
- 613.1±55.0 °C(Predicted)
- Density
- 1.476±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, away from moisture and light
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 9.01±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CFN96956
- Product name
- ProtosappaninA
- Packaging
- 10mg
- Price
- $318
- Updated
- 2021/12/16
- Product number
- JR8-N0793
- Product name
- protosappaninA(NewProduct)
- Purity
- 98%
- Packaging
- 5mg
- Price
- $398
- Updated
- 2021/12/16
protosappanin A Chemical Properties,Usage,Production
Description
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.
Uses
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
Definition
ChEBI: Protosappanin A is a member of catechols. It has a role as a metabolite.
IC 50
JAK2; STAT3
References
[1] Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15(9):674-679. DOI:10.1016/S1875-5364(17)30096-1
[2] Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14(4): 558- 569. DOI:10.1016/j.intimp.2012.09.004
protosappanin A Preparation Products And Raw materials
Raw materials
Preparation Products
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