ChemicalBook > CAS DataBase List > 2-Methoxy-6-(methylamino)pyridine

2-Methoxy-6-(methylamino)pyridine

Product Name
2-Methoxy-6-(methylamino)pyridine
CAS No.
88569-83-9
Chemical Name
2-Methoxy-6-(methylamino)pyridine
Synonyms
m131;2-METHOXY-6-PICOLINE;6-METHOXY-2-PICOLINE;methoxymethylaminopyridine;2-METHOXY-6-METHYLPYRIDINE;2-Methoxy-6-(methylamino)pyridine;6-Methoxy-N-methyl-2-pyridinamine;N-Methyl-2-aMino-6-Methoxypyridine;2-Methoxy-6-methylaminopyridine>2-PYRIDINAMINE, 6-METHOXY-N-METHYL-
CBNumber
CB2131579
Molecular Formula
C7H10N2O
Formula Weight
138.17
MOL File
88569-83-9.mol
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2-Methoxy-6-(methylamino)pyridine Property

Boiling point:
231.5±25.0 °C(Predicted)
Density 
1,09 g/cm3
refractive index 
1.5595
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
5.04±0.10(Predicted)
form 
clear liquid
color 
Colorless to Light orange to Yellow
InChI
InChI=1S/C7H10N2O/c1-8-6-4-3-5-7(9-6)10-2/h3-5H,1-2H3,(H,8,9)
InChIKey
GXHQLRBOZRJHPZ-UHFFFAOYSA-N
SMILES
C1(NC)=NC(OC)=CC=C1
CAS DataBase Reference
88569-83-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-43-22
Safety Statements 
26-36-36/37
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M1185
Product name
2-Methoxy-6-methylaminopyridine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$123
Updated
2023/01/07
Apolloscientific
Product number
OR923913
Product name
2-Methoxy-6-methylaminopyridine
Purity
95%
Packaging
25g
Price
$327
Updated
2021/12/16
AK Scientific
Product number
P454
Product name
2-Methoxy-6-(methylamino)pyridine
Packaging
100g
Price
$410
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0008992
Product name
2-METHOXY-6-METHYLAMINOPYRIDINE
Purity
95.00%
Packaging
100G
Price
$2541
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0008992
Product name
2-METHOXY-6-METHYLAMINOPYRIDINE
Purity
95.00%
Packaging
1KG
Price
$7484.4
Updated
2021/12/16
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2-Methoxy-6-(methylamino)pyridine Chemical Properties,Usage,Production

Uses

2-Methoxy-6-(methylamino)pyridine is used as an intermediate ingredient in the synthesis of Liranaftate, a topical antifungal agent used primarily for the treatment of skin infections caused by fungi.

Synthesis

17228-64-7

74-89-5

88569-83-9

General procedure for the synthesis of 2-methoxy-6-(methylamino)pyridine from 2-chloro-6-methoxypyridine and monomethylamine: 2-chloro-6-methoxypyridine (12.0 g, 85.6 mmol) was mixed with 40% aqueous methanamine (24 mL) in a sealed tube and reacted for 7 hr at 170 °C. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 50 mL of water and subsequently extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed sequentially with 100 mL of water and 100 mL of brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (100-200 mesh, eluent 0 to 5% dichloromethane solution in methanol) to afford 6-methoxy-N-methylpyridin-2-amine (2.7 g, 31% yield) as a light yellow oil.1H NMR (400 MHz, CDCl3) δ 7.37 (t, J = 8.0 Hz, 1H), 6.04 (d, J = 8.0 Hz, 1H), 5.94 (d, J = 7.8 Hz, 1H), 4.39 (br. s, 1H), 3.86 (s, 3H), 2.90 (s, 3H).

References

[1] Patent: WO2018/73193, 2018, A1. Location in patent: Page/Page column 49

2-Methoxy-6-(methylamino)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methoxy-6-(methylamino)pyridine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Methoxy-6-(methylamino)pyridine 88569-83-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-26
Shaanxi Dideu Medichem Co. Ltd
Product
2-Methoxy-6-(methylamino)pyridine 88569-83-9
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Career Henan Chemical Co
Product
2-Methoxy-6-(methylamino)pyridine 88569-83-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-15

88569-83-9, 2-Methoxy-6-(methylamino)pyridineRelated Search:

2-Methoxy-6-methylaminopyridine 5-Amino-2-methoxypyridine DIMETHYLAMINOPYRIDINE, POLYMER-BOUND 2-Methoxyethanol 4-Dimethylaminopyridine 2,6-Lutidine 2-Methoxypyridine Pyridine 3-Aminopyridine 2-Aminopyridine 2-(Trifluoromethoxy)aniline 4-Amino-2-methoxypyridine (5,6-DIMETHYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID 1-(6-ETHOXYPYRIDIN-2-YL)PIPERAZINE Liranaftate 1-(6-BUTOXYPYRIDIN-2-YL)PIPERAZINE 2-Pyridinemethanamine,4-methoxy-(9CI) N-(6-METHOXY-PYRIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE

  • PYRIDINE, 2-METHOXY-6-METHYAMINO-, HCL
  • methoxymethylaminopyridine
  • 2-METHOXY-6-METHYLAMINOPYRIDINE 98+%
  • PYRIDINE, 2-METHOXY-6-METHYAMINO-(INTERMEDIATES OF LIRANAFTATE)
  • 6-METHOXY-2-PICOLINE
  • 2-METHOXY-6-PICOLINE
  • 2-METHOXY-6-METHYLPYRIDINE
  • 2-Methoxy-6-(methylamino)pyridine
  • 2-PYRIDINAMINE, 6-METHOXY-N-METHYL-
  • 6-methoxy-N-methyl-, monohydrochloride
  • m131
  • N-Methyl-2-aMino-6-Methoxypyridine
  • 2 - Methoxy -6 - A aMinopyridine CAS：
  • 6-Methoxy-N-methyl-2-pyridinamine
  • 2-Methoxy-6-methylaminopyridine&gt
  • 2-Methoxy-6-(methylamino)pyridine ISO 9001：2015 REACH
  • high quality 2-Methoxy-6-(methylamino)pyridine
  • 88569-83-9
  • C7H10N2O
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridines derivates
  • LIRANAFTATE