2-Methoxy-6-(methylamino)pyridine
- Product Name
- 2-Methoxy-6-(methylamino)pyridine
- CAS No.
- 88569-83-9
- Chemical Name
- 2-Methoxy-6-(methylamino)pyridine
- Synonyms
- m131;2-METHOXY-6-PICOLINE;6-METHOXY-2-PICOLINE;methoxymethylaminopyridine;2-METHOXY-6-METHYLPYRIDINE;2-Methoxy-6-(methylamino)pyridine;6-Methoxy-N-methyl-2-pyridinamine;N-Methyl-2-aMino-6-Methoxypyridine;2-Methoxy-6-methylaminopyridine>2-PYRIDINAMINE, 6-METHOXY-N-METHYL-
- CBNumber
- CB2131579
- Molecular Formula
- C7H10N2O
- Formula Weight
- 138.17
- MOL File
- 88569-83-9.mol
2-Methoxy-6-(methylamino)pyridine Property
- Boiling point:
- 231.5±25.0 °C(Predicted)
- Density
- 1,09 g/cm3
- refractive index
- 1.5595
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 5.04±0.10(Predicted)
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- InChI
- InChI=1S/C7H10N2O/c1-8-6-4-3-5-7(9-6)10-2/h3-5H,1-2H3,(H,8,9)
- InChIKey
- GXHQLRBOZRJHPZ-UHFFFAOYSA-N
- SMILES
- C1(NC)=NC(OC)=CC=C1
- CAS DataBase Reference
- 88569-83-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-43-22
- Safety Statements
- 26-36-36/37
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M1185
- Product name
- 2-Methoxy-6-methylaminopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $123
- Updated
- 2023/01/07
- Product number
- OR923913
- Product name
- 2-Methoxy-6-methylaminopyridine
- Purity
- 95%
- Packaging
- 25g
- Price
- $327
- Updated
- 2021/12/16
- Product number
- P454
- Product name
- 2-Methoxy-6-(methylamino)pyridine
- Packaging
- 100g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- CHM0008992
- Product name
- 2-METHOXY-6-METHYLAMINOPYRIDINE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $2541
- Updated
- 2021/12/16
- Product number
- CHM0008992
- Product name
- 2-METHOXY-6-METHYLAMINOPYRIDINE
- Purity
- 95.00%
- Packaging
- 1KG
- Price
- $7484.4
- Updated
- 2021/12/16
2-Methoxy-6-(methylamino)pyridine Chemical Properties,Usage,Production
Uses
2-Methoxy-6-(methylamino)pyridine is used as an intermediate ingredient in the synthesis of Liranaftate, a topical antifungal agent used primarily for the treatment of skin infections caused by fungi.
Synthesis
17228-64-7
74-89-5
88569-83-9
General procedure for the synthesis of 2-methoxy-6-(methylamino)pyridine from 2-chloro-6-methoxypyridine and monomethylamine: 2-chloro-6-methoxypyridine (12.0 g, 85.6 mmol) was mixed with 40% aqueous methanamine (24 mL) in a sealed tube and reacted for 7 hr at 170 °C. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 50 mL of water and subsequently extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed sequentially with 100 mL of water and 100 mL of brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (100-200 mesh, eluent 0 to 5% dichloromethane solution in methanol) to afford 6-methoxy-N-methylpyridin-2-amine (2.7 g, 31% yield) as a light yellow oil.1H NMR (400 MHz, CDCl3) δ 7.37 (t, J = 8.0 Hz, 1H), 6.04 (d, J = 8.0 Hz, 1H), 5.94 (d, J = 7.8 Hz, 1H), 4.39 (br. s, 1H), 3.86 (s, 3H), 2.90 (s, 3H).
References
[1] Patent: WO2018/73193, 2018, A1. Location in patent: Page/Page column 49
2-Methoxy-6-(methylamino)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methoxy-6-(methylamino)pyridine Suppliers
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- Fax
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- Country
- Ukraine
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- 5026
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View Lastest Price from 2-Methoxy-6-(methylamino)pyridine manufacturers
- Product
- 2-Methoxy-6-(methylamino)pyridine 88569-83-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-26
- Product
- 2-Methoxy-6-(methylamino)pyridine 88569-83-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- 2-Methoxy-6-(methylamino)pyridine 88569-83-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-15