ChemicalBook > CAS DataBase List > 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

Product Name
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
CAS No.
152628-03-0
Chemical Name
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid
Synonyms
4-METHYL-2-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID;2-N-PROPYL-4-METHYL-6-CARBOXY-BENZIMIDAZOLE;Single-imidazole;2-N-Propyl-4-Meth;Telmisartan Intermediate 3;BENZIMIDAZOLE CARBOXYLIC ACID;TelMisartan BenziMidazole Acid;Telmisartan Benzimidazole Acid Impurity;6-Carboxy-4-methyl-2-propylbenzimidazole;4-METHYL-2-PROPYL-6-CARBOXYL BENZIMIDAZOLE
CBNumber
CB2133083
Molecular Formula
C12H14N2O2
Formula Weight
218.25
MOL File
152628-03-0.mol
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4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Property

Melting point:
300 °C
Boiling point:
491.8±25.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
3.19±0.30(Predicted)
form 
Powder
color 
Pale Yellow to Tan
InChIKey
XWAJTVCEILFDGU-UHFFFAOYSA-N
CAS DataBase Reference
152628-03-0(CAS DataBase Reference)
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Safety

HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2000
Product name
4-Methyl-2-propyl-6-benzimidazolecarboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$60
Updated
2025/07/31
Usbiological
Product number
B1062
Product name
1H-Benzimidazole-6-carboxylic-4-methyl-2-propyl
Packaging
1g
Price
$403
Updated
2021/12/16
TRC
Product number
B197825
Product name
1H-Benzimidazole-4-methyl-2-propyl-6-carboxylicAcid
Packaging
5g
Price
$440
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0011993
Product name
4-METHYL-2-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$704.55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18198
Product name
1H-Benzimidazole-4-methyl-2-propyl-6-carboxylic acid
Packaging
25g
Price
$420
Updated
2021/12/16
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4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Light Yellow to Tan Powder

Uses

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid is a useful synthetic intermediate,a useful compound in organic synthesis.

Synthesis

152628-01-8

152628-03-0

Example 4: Methyl 3-methyl-4-butyrylamino-5-nitrobenzoate (II) (10 g, 0.036 mol) was suspended in 60 ml of water and heated to 70-80 °C. A suspension of sodium dithionite (21.75 g, 0.124 mol) in 60 ml of water was added slowly and heated to 90-100 °C. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 10-11 and the temperature was maintained with continued stirring until TLC detection showed complete disappearance of methyl 3-methyl-4-butyrylamino-5-nitrobenzoate. Subsequently, the pH of the reaction mixture was adjusted to 6-6.5. The resulting solid was filtered and dried at 45-50 °C to afford 2-n-propyl-4-methyl-6-carboxybenzimidazole (7.5 g, yield: 96.4%).

References

[1] Patent: WO2012/28925, 2012, A2. Location in patent: Page/Page column 18
[2] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 6, p. 1107 - 1112
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 25, p. 4040 - 4051
[4] Patent: WO2012/28925, 2012, A2
[5] Organic Process Research and Development, 2007, vol. 11, # 1, p. 81 - 85

4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Preparation Products And Raw materials

Raw materials

3-Methyl-4-nitrobenzoic acid Nickel Hydrazine hydrate Triethylamine Butyryl chloride Nitric acid Acetic acid Methanol Sulfuric acid

Preparation Products

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4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid Suppliers

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View Lastest Price from 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid 152628-03-0
Price
US $25.00/ASSAYS
Min. Order
100ASSAYS
Purity
99.5%
Supply Ability
100 mt
Release date
2024-11-19
Henan Aochuang Chemical Co.,Ltd.
Product
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid 152628-03-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10
Shaanxi Haibo Biotechnology Co., Ltd
Product
4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid 152628-03-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-28

152628-03-0, 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acidRelated Search:

Propyl gallate Methyl salicylate N,N-Dimethylallylamine 3-Methyl-2-butanone Benzimidazole Cyclopropyl methyl ketone Isopropyl alcohol Propyl butyrate 2-Methylbenzimidazole Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate ALLYL METHYL ETHER Methyl 4'-bromomethyl biphenyl-2-carboxylate tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Thiophanate-methyl Methyl 2-METHYLPENTANE Methyl bromide 1H-Benzimidazole-5-carboxylic acid

  • 4-METHYL-2-N-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID
  • 4-METHYL-2-PROPYL-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID
  • 4-METHYL-2-PROPYL-6-CARBOXYL BENZIMIDAZOLE
  • 2-N-PROPYL-4-METHYL-6-CARBOXY-BENZIMIDAZOLE
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  • Telmisartan Intermediate 3
  • 2-N-Propyl-4-Meth
  • 6-Carboxy-4-methyl-2-propylbenzimidazole
  • 1H-Benzimidazole-4-methyl-2-propyl-6-carboxylic Acid
  • 4-Methyl-2-Propyl-1h-Benzimidazole-6-Carboxyboxylic Acid
  • 1H-BENZIMIDAZOLE-6-CARBOXYLIC-4-METHYL-2-PROPYL
  • 4-Methyl-2-Propyl-1H-Benzimidazole-6-CarboxylicAcid[TelmisartanIntermediates]
  • 2-N-Propyl-4-Methyl-6-Carbony-Benzimidazole
  • 2-PROPYL-4-METHYL-1H-BENZIMIDAZOLE-6-CARBOXYLICACID
  • 1H-Benzimidazole-5-carboxylic acid, 7-methyl-2-propyl,
  • 1H-Benzimidazol-5-carbonsure, 7-methyl-2-propyl-
  • 4-METHYL-2-PROPYL-6-BENZIMIDAZOLECARBOXYLIC ACID
  • 2-n-Propyl-4-Methyl-6-Carboxylate-1H-Benzimidazole
  • 7-methyl-2-propyl-3H-benzo[d]imidazole-5-carboxylic acid
  • 4-Methyl-2-propyl-1H-1,3-benzodiazole-6-carboxylic acid
  • 2-n-propyl-4-Methyl-6-carboxy-benziMidazole 3
  • 4-Methyl-2-propyl-1H-benzo[d]iMidazole-6-carboxylic acid
  • TelMisartan BenziMidazole Acid
  • 2-n-propyl-1H-benzimidazole-6-carboxylic acid
  • Single-imidazole
  • 7-methyl-2-propyl-3aH-benzimidazole-5-carboxylic acid
  • Telmisartan Benzimidazole Acid Impurity
  • 4-Methyl-2-propyl-6-benzimidazolecarboxylicAcid&gt
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  • Telmisartan Benzimidazole AcidQ: What is Telmisartan Benzimidazole Acid Q: What is the CAS Number of Telmisartan Benzimidazole Acid Q: What is the storage condition of Telmisartan Benzimidazole Acid Q: What are the applications of Telmisartan Benzimidazole Acid
  • 4-Methyl-2-n-propyl-6-carboxylic benzimidazole
  • 4-Methyl-2-n-propyl-1H-benzimidazoIe-6-carbox
  • 4-Methyl-2-Propylbenzimidazole-6-Carboxylic Acid
  • BENZIMIDAZOLE CARBOXYLIC ACID
  • 7-methyl-2-propaneyl-(1H)-benzoimidazole-5-carboxylic acid
  • 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylicacid (BIM-I)
  • 2-Propyl-4-methyl-6-carboxylic benzimidazole
  • 7-Methyl-2-propyl-1H-benzo[d]imidazol-5-carboxylic acid
  • 152628-03-0
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  • Imidazoles
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  • INTERMEDIATESOF
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