dihydroberberine
- Product Name
- dihydroberberine
- CAS No.
- 483-15-8
- Chemical Name
- dihydroberberine
- Synonyms
- Nsc331264;Dihydroberbine;dihydroberberine;Dihyddroberberine;DihydrouMbellatine;Dihydroberberine-RM;dihydroberberine CAS;Berberine Dihydro Impurity;Dihydroberberine/Dihydroumbellatine;9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydrob
- CBNumber
- CB21331789
- Molecular Formula
- C20H19NO4
- Formula Weight
- 337.37
- MOL File
- 483-15-8.mol
dihydroberberine Property
- Melting point:
- 223-224℃ (dec.)
- Boiling point:
- 557.8±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO
- pka
- 3.08±0.20(Predicted)
- form
- crystals
- color
- Yellow
- Water Solubility
- Soluble to 57.46 mg/l in water
- InChI
- InChI=1S/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3
- InChIKey
- FZAGOOYMTPGPGF-UHFFFAOYSA-N
- SMILES
- C12C=C3C(=CC=1CCN1C2=CC2=CC=C(OC)C(OC)=C2C1)OCO3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D446915
- Product name
- Dihydroberberine
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 446983
- Product name
- Dihydroberberine
- Packaging
- 10mg
- Price
- $418
- Updated
- 2021/12/16
- Product number
- CS-0018246
- Product name
- Dihydroberberine
- Packaging
- 5mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- orb259203
- Product name
- Dihydroberberine
- Purity
- 98%
- Packaging
- 20mg
- Price
- $408
- Updated
- 2021/12/16
- Product number
- CS-0018246
- Product name
- Dihydroberberine
- Packaging
- 20mg
- Price
- $343
- Updated
- 2021/12/16
dihydroberberine Chemical Properties,Usage,Production
Description
Dihydroberberine: a natural derivative of Berberine
Dihydroberberine (DHB) is emerging as a popular supplement for its enhanced bioavailability and therapeutic efficacy compared to its precursor, Berberine. Berberine, a natural compound, has been widely used for its antimicrobial and anti-inflammatory properties. It has also shown promise in improving glucose and lipid metabolism, supporting cardiovascular health, and offering neuroprotective effects.
Uses
Dihydroberberine is a derivative Berberine (B318150), an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells.
Definition
ChEBI: Lambertine is an alkaloid.
Synthesis
Briefly, 5% sodium hydroxide solution (27?mL) containing sodium borohydride (2.7?g) was added to a stirred solution of berberine chloride (11.06?g) and potash (13.1?g) in methanol (150?mL) dropwise. After stirring the reaction mixture at ambient temperature for 3?h, the precipitation was filtered and scrubbed with 30% ethanol (200?mL) followed by 80% ethanol (100?mL). The green–brown crystals were filtered and dried at 30?°C and were then collected to afford 9.4?g (yield: 85%) Dihydroberberine[1].
References
[1] Lihua Tan . “Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.” International immunopharmacology 75 (2019): Article 105802.
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Raw materials
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View Lastest Price from dihydroberberine manufacturers
- Product
- Dihydroberberine/Dihydroumbellatine 483-15-8
- Price
- US $600.00-400.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- Ex：10T
- Release date
- 2024-11-19
- Product
- dihydroberberine 483-15-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-14
- Product
- Dihydroberberine 483-15-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.5%
- Supply Ability
- 20ton
- Release date
- 2023-12-29