ChemicalBook > CAS DataBase List > yakuchinone-A

yakuchinone-A

Product Name: yakuchinone-A
CAS No.: 78954-23-1
Chemical Name: yakuchinone-A
Synonyms: yakuchinone-A;Yakuchinone A, 10 mM in DMSO;1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptan-3-one;3-Heptanone, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-;1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone
CBNumber: CB21344905
Molecular Formula: C20H24O3
Formula Weight: 312.4
MOL File: 78954-23-1.mol

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yakuchinone-A Property

Boiling point:: 212-214 °C(Press: 2 Torr)
Density: 1.095±0.06 g/cm3(Predicted)
solubility: DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
pka: 10.02±0.20(Predicted)
form: Liquid
color: Colorless to off-white
InChI: InChI=1S/C20H24O3/c1-23-20-15-17(12-14-19(20)22)11-13-18(21)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,12,14-15,22H,5-6,9-11,13H2,1H3
InChIKey: TXELARZTKDBEKS-UHFFFAOYSA-N
SMILES: C(C1=CC=C(O)C(OC)=C1)CC(=O)CCCCC1=CC=CC=C1
LogP: 3.720 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: Y0022
Product name: Yakuchinone A
Packaging: 50MG
Price: $312
Updated: 2025/07/31

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yakuchinone-A Chemical Properties,Usage,Production

Uses

Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].

Definition

ChEBI: A ketone that is heptan-3-one substituted by a 4-hydroxy-3-methoxyphenyl group at position 1 and a phenyl group at position 7. Isolated from in Alpinia oxyphylla, it exhibits antineoplastic and inhibitory activities against COX-1, COX-2 and NO synthase.

in vivo

Yakuchinone A (50 mg/kg, i.p., daily, 14 days) can reduce the symptoms of EAE in mice in autoimmune encephalomyelitis (EAE) mouse model^[1].

Animal Model:	Female C57BL/6 mice^[1]
Dosage:	50 mg/kg
Administration:	i.p., daily, 14 days
Result:	Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset.

References

[1] Chen Huo, et al. Microbial Transformation of Yakuchinone A and Cytotoxicity Evaluation of Its Metabolites.?Int J Mol Sci. 2022 Apr 3;23(7):3992.
[2] Kuo-Kuei Huang, et al. Alpinia oxyphylla?Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells. Evid Based Complement Alternat Med. 2019 Mar 14;2019:6797030. DOI:10.1155/2019/6797030

yakuchinone-A Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from yakuchinone-A manufacturers

shandong perfect biotechnology co.ltd

Product: Yakuchinone A 78954-23-1
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2024-01-10

78954-23-1, yakuchinone-ARelated Search:

Artemether beta-Sitosterol beta-Eudesmol hydroxygenkwanin (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one MOSLOFLAVONE alpha-Terpineol alpha-Cyperone NOOTKATONE 5-HYDROXY-7-METHOXYFLAVONE Hydroxyecdysone

yakuchinone-A

1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone

3-Heptanone, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-

1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptan-3-one

Yakuchinone A, 10 mM in DMSO

78954-23-1