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stephanine

Product Name: stephanine
CAS No.: 517-63-5
Chemical Name: stephanine
Synonyms: (7aR)-9-Methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline;5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-9-methoxy-7-methyl-, (7aR)-
CBNumber: CB21375022
Molecular Formula: C19H19NO3
Formula Weight: 309.36
MOL File: 517-63-5.mol

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stephanine Property

Melting point:: 155 °C
Boiling point:: 463.6±45.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Cryst.
pka: 7.03±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0002123
Product name: STEPHANINE
Purity: 95.00%
Packaging: 5MG
Price: $502.32
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS159607
Product name: Stephanine
Packaging: 2mg
Price: $550
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS159607
Product name: Stephanine
Packaging: 10mg
Price: $1300
Updated: 2021/12/16

AK Scientific

Product number: W1147
Product name: Stephanine
Packaging: 10mg
Price: $1805
Updated: 2021/12/16

Crysdot

Product number: CD32001152
Product name: Stephanine
Purity: 95+%
Packaging: 5mg
Price: $730
Updated: 2021/12/16

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stephanine Chemical Properties,Usage,Production

Description

l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit hyphal growth of the plant pathogens Cercospora kaki. 3. Stephanine, pseudopalmatine , tetrahydropalmatine , and xylopinine show significant antiplasmodial activities with IC(50) ranged from 2 uM to 53 uM.

Uses

Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer[1][2].

target

Adrenergic Receptor | Antifection

References

[1] Cui L, et, al. The anti-inflammatory and analgesic activities of 2Br-Crebanine and Stephanine from Stephania yunnanenses H. S.Lo. Front Pharmacol. 2023 Jan 4;13:1092583. DOI:10.3389/fphar.2022.1092583
[2] Le PM, et, al. Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit. Phytother Res. 2017 Sep;31(9):1357-1368. DOI:10.1002/ptr.5861

stephanine Preparation Products And Raw materials

Raw materials

Preparation Products

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stephanine Suppliers

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(7aR)-9-Methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline

517-63-5

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