norathyriol
- Product Name
- norathyriol
- CAS No.
- 3542-72-1
- Chemical Name
- norathyriol
- Synonyms
- rathyriol;norathyriol;Mangiferitin;Norathyriol, 10 mM in DMSO;1,3,6,7-Tetrahydroxyxanthone;1,3,6,7-Tetrahydroxy-9H-xanthen-9-one;9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-
- CBNumber
- CB21387988
- Molecular Formula
- C13H8O6
- Formula Weight
- 260.2
- MOL File
- 3542-72-1.mol
norathyriol Property
- Melting point:
- 320 °C
- Boiling point:
- 595.1±50.0 °C(Predicted)
- Density
- 1.766±0.06 g/cm3(Predicted)
- solubility
- DMSO : 100 mg/mL (384.32 mM; Need ultrasonic)
- form
- Solid
- pka
- 6.68±0.20(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H
- InChIKey
- ZHTQCPCDXKMMLU-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(O)C(O)=C2)OC2=C1C(O)=CC(O)=C2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AS296873
- Product name
- Norathyriol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $327
- Updated
- 2021/12/16
- Product number
- AR00C7EJ
- Product name
- norathyriol
- Purity
- 98%
- Packaging
- 5mg
- Price
- $393
- Updated
- 2021/12/16
- Product number
- CFN98468
- Product name
- Norathyriol
- Packaging
- 5mg
- Price
- $463
- Updated
- 2021/12/16
- Product number
- CD32001572
- Product name
- Norathyriol
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $730
- Updated
- 2021/12/16
- Product number
- CSN13488
- Product name
- Norathyriol
- Packaging
- 5mg
- Price
- $833
- Updated
- 2021/12/16
norathyriol Chemical Properties,Usage,Production
Uses
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12?μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
Definition
ChEBI: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity again t protein kinase C.
in vivo
Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7?mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].
| Animal Model: | Adult Kunming mice weighing 18-22?g[4] |
| Dosage: | 0.92, 1.85 and 3.7?mg/kg |
| Administration: | Administered intragastrically; twice daily for five times |
| Result: | The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%. |
IC 50
PPARα: 92.8 μM (IC50); PPARβ: 102.4 μM (IC50); PPARγ: 153.5 μM (IC50)
References
[1] Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015. DOI:10.1155/2017/1206015
[2] Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42. DOI:10.1021/jf800046n
[3] Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. DOI:10.1158/0008-5472.CAN-11-2596
[4] Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6. DOI:10.3109/13880209.2015.1120322
norathyriol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from norathyriol manufacturers
- Product
- norathyriol 3542-72-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- Norathyriol 3542-72-1
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19