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norathyriol

Product Name
norathyriol
CAS No.
3542-72-1
Chemical Name
norathyriol
Synonyms
rathyriol;norathyriol;Mangiferitin;Norathyriol, 10 mM in DMSO;1,3,6,7-Tetrahydroxyxanthone;1,3,6,7-Tetrahydroxy-9H-xanthen-9-one;9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-
CBNumber
CB21387988
Molecular Formula
C13H8O6
Formula Weight
260.2
MOL File
3542-72-1.mol
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norathyriol Property

Melting point:
320 °C
Boiling point:
595.1±50.0 °C(Predicted)
Density 
1.766±0.06 g/cm3(Predicted)
solubility 
DMSO : 100 mg/mL (384.32 mM; Need ultrasonic)
form 
Solid
pka
6.68±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H
InChIKey
ZHTQCPCDXKMMLU-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=C(O)C(O)=C2)OC2=C1C(O)=CC(O)=C2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Arctom
Product number
AS296873
Product name
Norathyriol
Purity
≥98%
Packaging
5mg
Price
$327
Updated
2021/12/16
Aaron Chemicals
Product number
AR00C7EJ
Product name
norathyriol
Purity
98%
Packaging
5mg
Price
$393
Updated
2021/12/16
Arctom
Product number
CFN98468
Product name
Norathyriol
Packaging
5mg
Price
$463
Updated
2021/12/16
Crysdot
Product number
CD32001572
Product name
Norathyriol
Purity
95+%
Packaging
5mg
Price
$730
Updated
2021/12/16
CSNpharm
Product number
CSN13488
Product name
Norathyriol
Packaging
5mg
Price
$833
Updated
2021/12/16
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norathyriol Chemical Properties,Usage,Production

Uses

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12?μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

Definition

ChEBI: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity again t protein kinase C.

in vivo

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7?mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].

Animal Model:Adult Kunming mice weighing 18-22?g[4]
Dosage:0.92, 1.85 and 3.7?mg/kg
Administration:Administered intragastrically; twice daily for five times
Result:The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

IC 50

PPARα: 92.8 μM (IC50); PPARβ: 102.4 μM (IC50); PPARγ: 153.5 μM (IC50)

References

[1] Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015. DOI:10.1155/2017/1206015
[2] Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42. DOI:10.1021/jf800046n
[3] Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. DOI:10.1158/0008-5472.CAN-11-2596
[4] Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6. DOI:10.3109/13880209.2015.1120322

norathyriol Preparation Products And Raw materials

Raw materials

Preparation Products

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norathyriol Suppliers

China 93 South Korea 1 United States 6 USA 1 Global 101
CHEMICAL LAND21
Tel
--
Fax
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Email
sales21@chemicalland21.com
Country
South Korea
ProdList
6303
Advantage
74
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View Lastest Price from norathyriol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
norathyriol 3542-72-1
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06
Shaanxi Dideu Medichem Co. Ltd
Product
Norathyriol 3542-72-1
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19

3542-72-1, norathyriolRelated Search:

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  • norathyriol
  • 1,3,6,7-Tetrahydroxy-9H-xanthen-9-one
  • 1,3,6,7-Tetrahydroxyxanthone
  • Mangiferitin
  • rathyriol
  • 9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-
  • Norathyriol, 10 mM in DMSO
  • 3542-72-1