5,6-Dimethylbenzimidazole
- Product Name
- 5,6-Dimethylbenzimidazole
- CAS No.
- 582-60-5
- Chemical Name
- 5,6-Dimethylbenzimidazole
- Synonyms
- dimethylbenzimidazole;5,6-DiMethyl-1H-benzo[d]iMidazole;dimedazol;5,6-DIMETHYL-1H-BENZIMIDAZOLE;C03114;5,6-DBI;dimesol;dimezol;NSC68316;AI3-52806
- CBNumber
- CB2142317
- Molecular Formula
- C9H10N2
- Formula Weight
- 146.19
- MOL File
- 582-60-5.mol
5,6-Dimethylbenzimidazole Property
- Melting point:
- 202-205 °C (lit.)
- Boiling point:
- 255.81°C (rough estimate)
- Density
- 1.0976 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- Soluble in ethanol (50 mg/ml).
- form
- Powder
- pka
- 13.48±0.30(Predicted)
- color
- Light beige
- Water Solubility
- soluble
- Merck
- 14,3236
- BRN
- 116595
- InChIKey
- LJUQGASMPRMWIW-UHFFFAOYSA-N
- CAS DataBase Reference
- 582-60-5(CAS DataBase Reference)
- EPA Substance Registry System
- 1H-Benzimidazole, 5,6-dimethyl- (582-60-5)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- DD8280000
- TSCA
- Yes
- HS Code
- 29339990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D147206
- Product name
- 5,6-Dimethylbenzimidazole
- Purity
- ≥99%
- Packaging
- 25g
- Price
- $67.1
- Updated
- 2025/07/31
- Product number
- 8.41278
- Product name
- 5,6-Dimethylbenzimidazole
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $55.13
- Updated
- 2021/12/16
- Product number
- 8.41278
- Product name
- 5,6-Dimethylbenzimidazole for synthesis. CAS 582-60-5, molar mass 146.19 g/mol., for synthesis
- Packaging
- 8412780025
- Price
- $57.6
- Updated
- 2021/12/16
- Product number
- D1345
- Product name
- 5,6-Dimethylbenzimidazole
- Purity
- >99.0%(GC)(T)
- Packaging
- 25g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- D477120
- Product name
- 5,6-Dimethylbenzimidazole
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
5,6-Dimethylbenzimidazole Chemical Properties,Usage,Production
Description
5,6-Dimethylbenzimidazole is a dimethylbenzimidazole that has been found in S. meliloti and is an intermediate in the biosynthesis of the corrin macrocycle vitamin B12 (Item No. 18425).1 It is formed from the flavin coenzyme riboflavin 5ʹ-monophosphate (Item No. 18167) by the oxidoreductase BluB in S. meliloti. 5,6-Dimethylbenzimidazole forms the axial region of vitamin B12 and chelates the central cobalt.WARNING This product is not for human or veterinary use.
Chemical Properties
light beige powder
Definition
ChEBI: A dimethylbenzimidazole carrying methyl substituents at positions 5 and 6.
Synthesis Reference(s)
Synthetic Communications, 16, p. 365, 1986 DOI: 10.1080/00397918608076319
Synthesis
15776-99-5
582-60-5
To a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbler was added N-benzylbenzimidazole (208.1 mg, 1.0 mmol), dried Pd/C catalyst (10 wt%, 20 mg) and THF (5 mL). Triethylsilane (320 μL, 2.0 mmol) was added dropwise to the mixture under nitrogen protection, followed by continuous stirring at room temperature for 14 hours. After completion of the reaction, the reaction mixture was filtered through a 0.45 μm PTFE syringe filter and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 0 to 10% methanol/dichloromethane gradient) to afford 5,6-dimethylbenzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). The reaction typically exhibits an induction period of 5 to 30 min, which can be observed by the phenomenon of gas release (i.e., bulging) from the reaction mixture. The use of a dry Pd/C catalyst is essential; wet Pd/C results in lower yields or the reaction does not proceed.
Purification Methods
Crystallise 5,6-dimethylbenzimidazole from diethyl ether. It sublimes at 140o/3mm. [Beilstein 23/6 V 454.]
References
[1] Tetrahedron Letters, 2015, vol. 56, # 21, p. 2688 - 2690
5,6-Dimethylbenzimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-Dimethylbenzimidazole manufacturers
- Product
- 5,6-Dimethylbenzimidazole 582-60-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 5,6-Dimethylbenzimidazole 582-60-5
- Price
- US $10.00-8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-14
- Product
- 5,6-Dimethylbenzimidazole 582-60-5
- Price
- US $100.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-08-25