ChemicalBook > CAS DataBase List > 1-Acetylpiperidin-4-amine

1-Acetylpiperidin-4-amine

Uses

Product Name: 1-Acetylpiperidin-4-amine
CAS No.: 160357-94-8
Chemical Name: 1-Acetylpiperidin-4-amine
Synonyms: 4-Amino-N-1-acetylpiperidine;1-ACETYLPIPERIDIN-4-AMINE;4-Piperidinamine, 1-acetyl-;4-AMINO-1-ACETYL-PIPERIDINE;1-ACETYL-4-AMINO-PIPERIDINE;1-N-Acetyl-4-aminopiperidine;1-Acetyl-4-piperidinyl)amine;1-Acetyl-4-aminopiperidine 97%;1-Acetyl-4-aminopiperidine,>97%;1-(4-Aminopiperidino)-1-ethanone
CBNumber: CB2146067
Molecular Formula: C7H14N2O
Formula Weight: 142.2
MOL File: 160357-94-8.mol

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1-Acetylpiperidin-4-amine Property

Boiling point:: 273.6±33.0 °C(Predicted)
Density: 1.042±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.37±0.20(Predicted)
form: oil
color: Colourless to light yellow
InChI: InChI=1S/C7H14N2O/c1-6(10)9-4-2-7(8)3-5-9/h7H,2-5,8H2,1H3
InChIKey: NLHBHVGPMMXWIM-UHFFFAOYSA-N
SMILES: C(=O)(N1CCC(N)CC1)C
CAS DataBase Reference: 160357-94-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36
Safety Statements: 26
RIDADR: UN2735
HazardClass: 8
PackingGroup: III
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3613
Product name: 1-(4-Aminopiperidin-1-yl)ethan-1-one
Purity: min. 95.0 %
Packaging: 200MG
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: A3613
Product name: 1-(4-Aminopiperidin-1-yl)ethan-1-one
Purity: min. 95.0 %
Packaging: 1G
Price: $120
Updated: 2025/07/31

TRC

Product number: A192255
Product name: 1-Acetyl-4-aminopiperidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 031023
Product name: 1-(4-Aminopiperidino)-1-ethanone
Packaging: 1g
Price: $54
Updated: 2021/12/16

Apolloscientific

Product number: OR17566
Product name: 1-Acetyl-4-aminopiperidine
Purity: 97%
Packaging: 1g
Price: $57
Updated: 2021/12/16

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1-Acetylpiperidin-4-amine Chemical Properties,Usage,Production

Uses

1-Acetyl-4-aminopiperidine is a heterocyclic organic compound with a density of 1.042 g/cm3 and a boiling point of 273.6ºCat760 mmHg. It is an important intermediate in the synthesis of piperidine drugs.

Synthesis

135581-16-7

160357-94-8

General procedure for the synthesis of 4-amino-N-1-acetylpiperidine from 1-acetylpiperidin-4-one (CAS: 135581-16-7, 10 g, 70 mmol): 1. Oximization reaction: 1-acetylpiperidin-4-one was dissolved in 200 mL of ethanol, hydroxylamine hydrochloride (10 g, 143 mmol) and pyridine (10 mL) were added. The reaction mixture was heated to 70 °C and maintained for 1.5 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was treated with cold water and cooled to 0 °C. The resulting slurry was filtered and dried under vacuum to give 1-acetylpiperidin-4-one oxime (6.5 g, white solid, 59% yield). 2. Hydrogenation reaction: The oxime (2.0 g, 12 mmol) prepared above was dissolved in 50 mL of ethanol, and nickel ruanne (0.2 g) was added after being washed several times with water. The mixture was transferred to a Parr reactor and hydrogenated at 50 psi hydrogen pressure for 16 hours. Upon completion of the reaction, the reaction mixture was carefully filtered and the filtrate was evaporated under reduced pressure to afford 4-amino-N-1-acetylpiperidine (1.7 g, green solid, 100% yield). The product was analyzed by GC-MS, m/z = 142.

References

[1] Patent: WO2004/110996, 2004, A1. Location in patent: Page/Page column 102
[2] Patent: US2008/227780, 2008, A1. Location in patent: Page/Page column 55

1-Acetylpiperidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Acetylpiperidin-4-amine manufacturers

Capot Chemical Co.,Ltd.

Product: 1-Acetyl-4-amino-piperidine 160357-94-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: kgs
Release date: 2023-01-03

Career Henan Chemical Co

Product: 1-Acetylpiperidin-4-amine 160357-94-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

160357-94-8, 1-Acetylpiperidin-4-amineRelated Search:

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1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE

4-AMINO-1-ACETYL-PIPERIDINE

4-Amino-N-1-acetylpiperidine

1-(4-Aminopiperidin-1-yl)ethan-1-one, 1-Acetylpiperidin-4-amine

Ethanone,1-(4-aMino-1-piperidinyl)-

4-Piperidinamine, 1-acetyl-

1-ACETYL-4-AMINO-PIPERIDINE

1-ACETYLPIPERIDIN-4-AMINE

1-(4-Aminopiperidino)-1-ethanone

1-acetyl-4-piperidinamine(SALTDATA: HCl)

1-(4-amino-1-piperidinyl)ethanone

1-Acetyl-4-aminopiperidine 97%

1-Acetyl-4-aminopiperidine,>97%

1-N-Acetyl-4-aminopiperidine

1-Acetyl-4-piperidinyl)amine

4-Amino-1-acetylpiperidine - [A12231]

160357-94-8

60357-94-8

Amines

Pyrans, Piperidines &Piperazines

Pyrans, Piperidines & Piperazines